Topic
Slow-wave sleep
About: Slow-wave sleep is a research topic. Over the lifetime, 6543 publications have been published within this topic receiving 320663 citations. The topic is also known as: deep sleep.
Papers published on a yearly basis
Papers
More filters
TL;DR: Electrographic and behavioral observations on five rodent species under controlled conditions showed well defined stages of slow wave sleep and paradoxical sleep in all animals, and hibernators also seemed to sleep more deeply than non-hibernators.
161 citations
TL;DR: In five male subjects, and a total of 15 man-nights, oxygen consumption rate (V02) was related to stage of sleep, as defined by electroencephalograms, with V02 highest in stage I REM (dreaming sleep), least in stages III and IV (deep sleep), and intermediate in stage II (light sleep).
Abstract: In five male subjects, and a total of 15 man-nights, oxygen consumption rate (V(02)) was related to stage of sleep, as defined by electroencephalograms. Gross periodic variations which paralleled change in stage of sleep were discernible in analogue metabolic records. Computations revealed significant differences (P <.01) between all stages with V(02) highest in stage I REM (dreaming sleep), least in stages III and IV (deep sleep), and intermediate in stage II (light sleep).
161 citations
TL;DR: The purpose was to study the effect of gabapentin (GBP) on sleep and the effects of the newer AEDs on sleep are unknown.
Abstract: Summary: Purpose: The older antiepileptic drugs (AEDs) have a variety of effects on sleep, including marked reduction in rapid-eye-movement (REM) sleep, slow-wave sleep (SWS), and sleep latency, and an increase in light sleep. The effects of the newer AEDs on sleep are unknown. Our purpose was to study the effect of gabapentin (GBP) on sleep.
Methods: Ten healthy adults and nine controls were the subjects of this study. All underwent baseline and follow-up polysomnography (PSG) and completed sleep questionnaires. After baseline, the treated group received GBP titrated to 1,800 mg daily. Polygraphic variables and Epworth Sleepiness Scale (ESS) scores, a subjective measure of sleep propensity, were compared by using the Wilcoxon signed rank test.
Results: Nine of the treated subjects achieved the target dose; one was studied with 1,500 mg daily because of dizziness experienced at the higher dose. GBP-treated subjects had an increase in SWS compared with baseline. No difference in the ESS or other polygraphic variables was observed. However, a minor reduction in arousals, awakenings, and stage shifts was observed in treated subjects.
Conclusions: GBP appears to be less disruptive to sleep than are some of the older AEDs. These findings may underlie the drug's therapeutic effect in the treatment of disorders associated with sleep disruption.
161 citations
TL;DR: Although patients with EDS showed a mild worsening of respiratory disturbance and sleep fragmentation, these results suggest that sleep apnea and sleep disruption are not the primary determinants of EDS in all of these patients.
161 citations
TL;DR: HA-containing neurons unit activity changes dramatically as a function of behavioral state across the sleep-wakefulness continuum, from 2.3 spikes/sec during active waking to virtual silence during slow wave sleep and REM sleep.
160 citations