Showing papers on "Small hairpin RNA published in 1981"
TL;DR: The results indicate that successively longer RNA sequences with the same 5′-ends fold sequentially, usually keeping the stable close-range hairpin loops and rearranging the long-range stems, which will shorten the time the messenger RNA molecule needs to attain its preferred structure.
55 citations
TL;DR: The primary sequence of a 5'-terminal fragment of poliovirus type 1 RNA, generated by digestion with RNase III, has been determined and reveals the presence of a stable hairpin structure beginning nine nucleotides from the terminally linked protein VPg.
Abstract: The primary sequence of a 5'-terminal fragment of poliovirus type 1 RNA, generated by digestion with RNase III, has been determined. This sequence reveals the presence of a stable hairpin structure beginning nine nucleotides from the terminally linked protein VPg. The sequence does not contain (i) the initiation codons AUG or GUG or (ii) the putative ribosome-binding sequence complementary to the 3' end of eucaryotic ribosomal 18S RNA. The stem-and-loop structure identified can be drawn in either plus or minus RNA strands. It is unclear to which strand functional significance (if any) can be assigned. It is possible that the hairpin structure is involved in ribosomal recognition and translation or in RNA synthesis by interacting with replicase molecules.
52 citations