Topic
Sodium dichromate
About: Sodium dichromate is a research topic. Over the lifetime, 421 publications have been published within this topic receiving 6202 citations. The topic is also known as: Disodium salt & sodium bichromate.
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TL;DR: The investigation of renal amino acid handling confirms that both CP and chromate are nephrotoxins, that CP was more neph rotoxic in 55-day-old animals compared to immature rats as could be demonstrated before using other parameters for nephRotoxicity testing and showed that determination of renal Amin acid handling is a highly sensitive marker for nePhrotoxicity testing, especially in immature rats.
Abstract: The effects of sodium dichromate (chromate; 1 mg/100 g b. wt. s.c.) and cisdiamminedichloroplatinum(II) (CP; 0.6 mg/100 g b. wt. i. p.) on renal amino acid excretion and plasma amino acid composition were investigated in 10- and 55-day-old anaesthetised rats. On the basis of diuresis experiments on conscious rats the mentioned doses and times (1st day after chromate in both age groups and in 10-day-old rats after CP and 3rd day after CP in adult rats) were found out to be optimal for the characterisation of amino acid transport after heavy metal poisoning. Interestingly, in conscious 10-day-old rats chromate nephrotoxicity is not detectable after 1 mg/100 g b. wt. whereas all of the other experimental groups showed nephrotoxic effects of chromate and CP in conscious rats. Urine volumes are lower, but not significantly, in anaesthetised immature rats, independently of the administered nephrotoxin. But GFR is significantly lower in 10-day-old rats, both in controls and after CP, whereas after chromate GFR is significantly reduced only in adult rats and age differences disappeared. In principle the renal fractional excretion (FE) of amino acids was distinctly higher in immature rats as a sign of lower amino acid reabsorption capacity. Nevertheless, the amino acid plasma concentrations were relatively high in immature rats. However, both chromate and CP did not distinctly influence amino acid plasma concentrations. But in both age groups the administration of chromate and CP significantly decreased amino acid reabsorption capacity (increase in FE) as a sign of nephrotoxicity, most pronounced in adult rats after CP. The investigation of renal amino acid handling confirms (1) that both CP and chromate are nephrotoxins, (2) that CP was more nephrotoxic in 55-day-old animals compared to immature rats as could be demonstrated before using other parameters for nephrotoxicity testing and showed (3) that determination of renal amino acid handling is a highly sensitive marker for nephrotoxicity testing, especially in immature rats.
12 citations
Journal Article•
12 citations
TL;DR: In this article, the anodized film of aluminum alloy was composed of an inner thin compact layer (the barrier layer) and an outer thick porous layer, and the sealing process was done by using sodium dichromate (Na2Cr2O7) potassium dichromates (K2Cr 2O7), and boiling water, respectively.
12 citations
Patent•
20 Jan 1993
TL;DR: In this article, a method to dye pure silk with a chromo-liquid extracted from a natural plant known as logwood was described, which showed red or yellow as well as derived secondary or triple colours.
Abstract: This invention discloses a method to dye pure silk with a chromo-liquid extracted from a natural plant known as logwood. It includer pre-mordanting, mixed mordanting and post-mordanting sreps by addition of potassium chromate, sodium chromate, potassium dichromate, sodium dichromate, cobalt sulfate, copper sulfate, ferrous sulfate, iron sulfate, aluminium sulfate, nickle sulfate, calcium chloride, alum and tannic acid. The mordant may be one or more of said material. The dyed pure silk shows red or yellow as well as derived secondary or triple colours. Its advantages are soft lustre, no decolouring, good recurrence nature, and half a class in chromatic aberration, and no poison, harm, and pollution.
12 citations
TL;DR: In adult rats dose dependence of nephrotoxicity was found concerning the extent and duration of renal damage, and at the beginning and in the recovery phase preferentially tubular damage was found.
Abstract: Investigations were performed on 10- and 55-day-old female Wistar rats. 1 or 2 mg sodium dichromate/100 g b. m. were administered subcutaneously. Urine was collected for 1 hour at different times after dichromate injection. Total urinary protein as well as some protein fractions (high and low molecular weight proteins as well as albumin) were determined. In adult rats dose dependence of nephrotoxicity was found concerning the extent and duration of renal damage. Separation of proteins gave an insight into the location of injury. At the beginning and in the recovery phase preferentially tubular damage was found. The peak of damage is characterized by additional glomerular disturbances. Young rats are much less susceptible to dichromate than adult rats are. Possible reasons are discussed.
11 citations