Sodium dichromate

About: Sodium dichromate is a research topic. Over the lifetime, 421 publications have been published within this topic receiving 6202 citations. The topic is also known as: Disodium salt & sodium bichromate.

Electrochemical process for the production of chromic acid

Abstract: The present invention relates to a process for the production of chromic acid CrO3, of high purity on the basis of the electrochemical principle, the measures to be taken comprising the process steps:… 1. preparation and purification of an aqueous sodium chromate/sodium dichromate solution,… 2. conversion of said sodium chromate/sodium dichromate solution into a sodium dichromate/chromic acid solution,… 3. crystallisation of chromic acid from said sodium chromate/chromic acid solution by evaporation,… 4. separation of the crystallised chromic acid from the mother liquor,… 5. recirculation of the separated mother liquor in the centrifuge.

Process for the production of chromium trioxide

Abstract: Chromium trioxide contaminated with sulphate is purified by washing with an aqueous purifying wash liquor, generally water or aqueous chromic acid, while at a temperature above 50° C. and centrifuging the washed product. Washing is generally conducted on the centrifuge. The chromium trioxide is preferably made by reacting sodium dichromate with from 2.4 to 2.8 mols sulphuric acid. The process can be operated to produce a novel product consisting of crystalline, non-fused, chromium trioxide that is substantially pure. The novel product can be in the form of pellets.

Process for preparing vitamin K3 by extraction method

Abstract: The invention relates to a process for preparing vitamin K3 through extraction method, which consists of using beta-methylnaphthalene, sodium dichromate, sulfuric acid and organic solvent as principal raw materials, using surface active agent as the catalyst, carrying out oxidation reaction under mild condition, finally conducting abstraction and addition. The invention is characterized in that, an extraction method is employed to extract 2-methyl-1,4-naphthoquinone into the organic solvent, thus inorganic foreign matter can be removed.

Comparison of the In Vitro Mutagenicity of Artemisia draconculus L. With Sodium Dichromate by Performing Single Cell Gel Electrophoresis (SCGE) or the Comet Assay

Abstract: Background: The increasing use of herbal drugs and their easy availability have necessitated the use of mutagenicity tests to analyze their toxicity and safety. Objectives: The aim of this study was to determine the in vitro mutagenicity of Artemisia draconculus L., a herbal drug, by performing single cell gel electrophoresis (SCGE). Material and Methods: In this study, we obtained a herbal drug with A. draconculus at a density of 0.94; doses of 100 μl, 200 μl, 400 μl, and 800 μl equivalent to 94 mg, 188 mg, 376 mg, and 752 mg of A. draconculus, respectively, were used. Sodium dichromate at a dose of 262 mg was considered to be the positive control, and blood was considered to be the negative control. Blood samples were centrifuged at 3500 rpm for 5 min, and the lower portion of the residue was isolated and mixed with low melting point agarose. Results: A cell suspension was prepared and applied on pre-coated agarose gel slides. Lysis, electrophoresis under alkaline conditions, staining of DNA, comet visualization, and comet scoring were carried out. The statistical analysis of the obtained results showed that with an increase in the dosage of A. draconculus, DNA damage also increased signifi cantly (P < 0.05). Conclusions: These findings provide valuable information regarding the safety and tox icity of this herbal drug, and this information will be helpful in ensuring rational use of this drug.

The Effect of Simvastatin on Sodium Dichromate-Induced Oxidative Stress

Abstract: Background: Hexavalent Chromium (CrVI) is used for various industrial applications. This chemical agent can cause inflammation and induce numerous human diseases, including severe damage to the liver and lung. Simvastatin (SIMV) is widely clinically used for lowering hypercholesterolemia. This agent also has anti-inflammatory, anti-oxidant, and anti-thrombotic effects. Objectives: The aim of the present study was to investigate the role of SIMV on sodium dichromate (Cr VI)-induced oxidative stress in rat. Materials and Methods: Sixty-four adult male Wistar rats (180-220 g weight) were randomly assigned to eight groups (n = 8). Group one received SIMV 20 mg/kg/day. Group two was given vehicle only. Groups three, five and seven received intraperitoneally (i.p) sodium dichromate at doses of 8, 12 and 16 mg/kg BW (Body Weight) for eight consecutive days, respectively. Groups four, six and eight pretreated with the 20 mg/kg SIMV 30 minutes to prior administration of sodium dichromate in a doses of 8, 12 and 16 mg/kg, respectively. The experiment repeated for eight consecutive days. Twenty-four hours after the last administration, animals were killed with overdose of sodium pentobarbital. Blood was collected for determination of malondialdehyd (MDA) and glutathione (GSH) levels. Results: The level of GSH significantly decreased. In contrast, the plasma level of MDA significantly increased in a dose dependent manner in CrVI-treated rats, when compared to control animals. SIMV had no effect on the biochemical parameters when compared to control rats, but significantly increased GSH concentration and decreased MDA level in CrVI-treated rats. Conclusions: This finding suggests that SIMV may have a protective effect against CrVI-induced oxidative stress.