Showing papers on "Sodium propionate published in 2016"
TL;DR: Oral administration of sodium propionate could ameliorate DSS-induced colitis mainly by improving intestinal barrier function and reducing inflammation and oxidative stress via the STAT3 signaling pathway.
Abstract: Propionate is a short chain fatty acid and abundant as butyrate in the gut and blood. However, propionate has been studied less extensively than butyrate in the treatment of colitis. The present study was to investigate the effects of sodium propionate on intestinal barrier function, inflammation and oxidative stress in dextran sulfate sodium (DSS)-induced mice. Animals in DSS group received drinking water from 1 to 6 days and DSS (3% (w/v) dissolved in double distilled water) instead of drinking water from 7 to 14 days. Animals in DSS+Prop group were given 1% sodium propionate for 14 consecutive days and supplemented with 3% DSS solution on day 7-14. Intestinal barrier function, proinflammatory factors, oxidative stress, and signal transducer and activator of transcription 3 (STAT3) signaling pathway in the colon were determined. It was found that sodium propionate ameliorated body weight loss, colon-length shortening and colonic damage in colitis mice. Sodium propionate significantly inhibited the increase of FITC-dextran in serum and the decrease of zonula occludens-1 (ZO-1), occludin and E-cadherin expression in the colonic tissue. It also inhibited the expression of interleukin (IL)-1β, IL-6 and tumor necrosis factor-α (TNF-α) mRNA and phosphorylation of STAT3 in colitis mice markedly, reduced the myeloperoxidase (MPO) level, and increased the superoxide dismutase (SOD) and catalase (CAT) level in colon and serum compared with DSS group. Sodium propionate inhibited macrophages with CD68 marker infiltration into the colonic mucosa of colitis mice. These results suggest that oral administration of sodium propionate could ameliorate DSS-induced colitis mainly by improving intestinal barrier function and reducing inflammation and oxidative stress via the STAT3 signaling pathway.
183 citations
TL;DR: It is possible to conclude that dietary supplementation with propionate and butyrate in different dietary concentrations modify the intestinal microbiota and improves the growth of L. vannamei.
Abstract: Organic salts may improvement the animal performance, increasing the efficiency of nutrient utilization and modifying the intestinal microbiota. This study aimed to evaluate the effects of sodium butyrate and sodium propionate supplementation at different levels of dietary inclusions in the growth of Litopenaeus vannamei. In total, seven diets were evaluated: a control diet (without supplementation) and three diets from each sodium salt, propionate and butyrate, in concentrations of 0.5%, 1% and 2%. We used 21 tanks of 6000 L stocked with 150 shrimps (2.53 � 0.03 g). The shrimps fed diets supplemented with propionate and butyrate, in all concentrations, increased their final weight. The feed efficiency, nitrogen retention, protein efficiency rate, survival and yield of shrimps fed the diet containing 2% butyrate were higher in comparison with control treatment. The shrimps supplemented with butyrate also showed lower counts of Vibrio sp. in the intestine. The shrimps fed the diet supplemented with butyrate and propionate also showed higher values of serum agglutination titre. Thus, it is possible to conclude that dietary supplementation with propionate and butyrate in different dietary concentrations modify the intestinal microbiota and improves the growth of L. vannamei.
90 citations
TL;DR: Beneficial effects of dietary sodium propionate on mucosal immune response as well as the antioxidant defense of zebra fish are shown.
Abstract: The present study explores the effect of dietary sodium propionate on mucosal immune response and expression of antioxidant enzyme genes in zebra fish (Danio rerio). Six hundred healthy zebra fish (0.42 ± 0.06 g) supplied, randomly stocked in 12 aquariums and fed on basal diets supplemented with different levels of sodium propionate [0 (control), 5, 10 and 20 g kg-1] for 8 weeks. At the end of the feeding trial, mucosal immune parameters (TNF-α, IL-1β, Lyz), antioxidant enzyme (SOD, CAT) as well as heat shock protein 70 (HSP70) gene expression were measured. The results revealed feeding on sodium propionate significantly up-regulated inflammatory response genes (TNF-α, IL-1β, Lyz) in a dose-dependent manner (P < 0.05). However, antioxidant enzyme genes significantly down-regulated in the treated group compared with control (P < 0.05). Also, HSP70 gene expression was higher in the liver of fish fed the basal diet and deceased with elevation of sodium propionate levels in the diet. These results showed beneficial effects of dietary sodium propionate on mucosal immune response as well as the antioxidant defense of zebra fish.
78 citations
TL;DR: Air infiltration during fermentation tested in one trial did not alter lactic acid production, but resulted in more acetic acid in delayed and more ethanol than in promptly sealed untreated silages, and a trend toward reduced ethanol production was observed.
78 citations
TL;DR: The mechanism and role of two 3-hydroxyvalerate (3-HV) inducing substrates on the production of PHBV with high, 80%, 3- HV content were evaluated and it was found that levulinic acid contributes to biomass and bio-polymer content enhancement, whereas sodium propionate mainly contributes to 3-Hv enhancement.
17 citations
TL;DR: This is the first reported study showing improvements to the survival and growth of crabs fed with inclusions of dietary organic acids, and no structural differences in all treatments or staining intensity for glycogen.
Abstract: Organic acids are receiving increasing attention as a potential means to improve the growth as well as nutrient utilization of aquatic animals. A 20-day experiment was conducted to compare the effects of different dietary organic acid salts that included sodium acetate, sodium citrate, sodium butyrate, or sodium propionate at 2%, on the survival, growth, and hepatopancreatic histopathology of blue swimmer crab Portunus pelagicus early juveniles. All diets were isonitrogenous and were provided to apparent satiation twice daily. Crabs were kept individually within plastic containers, and there were 45 replicate crabs for each treatment. Results showed that, by the third molt, all the tested dietary organic acids significantly (P < 0.05) accelerated the molting (7.16–8.65 days) of the crabs compared with those in the control treatment (10.03 days). The specific growth rate (SGR) for width and length as well as the final dry weights were significantly higher (P < 0.05) in all the organic acid treatments, while SGR for weight was significantly higher (P < 0.05) in the sodium acetate and sodium propionate treatments, compared with the control. Hepatopancreatic histopathology revealed no structural differences in all treatments or staining intensity for glycogen. To our knowledge, this is the first reported study showing improvements to the survival and growth of crabs fed with inclusions of dietary organic acids.
14 citations
TL;DR: The densities, viscosities and enthalpies of dilution of l-serine and l-proline have been determined in water and in aqueous solutions of sodium propionate and calcium Propionate at different temperatures to elucidate the changes in taste quality and hydration number of l
9 citations
TL;DR: The results indicated a reduction of ketone bodies in all three treatment groups as discussed by the authors and the largest reduction in BBHB concentration after two weeks showed group SP-H with a difference by trend to group SP (p=0.06), but not to group PL.
6 citations
Patent•
13 Jul 2016
TL;DR: In this paper, a method for preparing a loxoprofen intermediate comprises the following steps that 1, on the presence of sodium alkoxide, benzyl cyanide and dimethyl carbonate are subjected to methylation in an organic solvent.
Abstract: A method for preparing a loxoprofen intermediate comprises the following steps that 1, on the presence of sodium alkoxide, benzyl cyanide and dimethyl carbonate are subjected to methylation in an organic solvent, and 2-(phenyl cyano) sodium propionate is obtained; 2, 2-(phenyl cyano) sodium propionate and dimethyl sulfate react in an organic solvent to obtain 2-(phenyl cyano) methyl propionate; 4, 2-(phenyl cyano) methyl propionate reacts under the alkaline condition to obtain 2-phenyl propionitrile; 4, 2-phenyl propionitrile is hydrolyzed under the alkaline condition, acid is added for acidizing after the reaction to obtain 2-phenylpropionic acid; 5, 2-phenylpropionic acid, hydrobromic acid and paraformaldehyde are mixed and subjected to a bromine methylation reaction under the acidic condition, and 2-(4-tribromomethyl phenyl) propionic acid is obtained.According to the method, a new synthesis route is designed, product selectivity is good, the purity is high, the conversion rate is high, and few by-products are generated; the raw materials are simple and easy to obtain, the production conditions are mild, the process is simple, production cost is low, and pollution is small.
5 citations
Patent•
16 Nov 2016
TL;DR: In this paper, a method for separating vitamin B12 and propionic acid from fermentation liquid is proposed, which mainly comprises the steps of ultrafiltration membrane separation, breaking of thallus cell walls by a mechanical method, extraction of vitamin b12, and nanofiltration membrane or reverse osmosis membrane concentration.
Abstract: The invention relates to a method for separating vitamin B12 and propionic acid from fermentation liquid. The fermentation liquid is produced by fermentation culture of propionibacterium. The method mainly comprises the steps of ultrafiltration membrane separation, breaking of thallus cell walls by a mechanical method, extraction of vitamin B12, and nanofiltration membrane or reverse osmosis membrane concentration, extraction and back extraction. The method for separating vitamin B12 and propionic acid from fermentation liquid, provided by the invention, is suitable for the fermentation liquid produced by fermentation culture of propionibacterium; the method realizes a high speed of separating vitamin B12 and propionic acid; few extracting agents are used in the extraction process, and the extracting agent rate is high, wherein the extraction rate (mass fraction) of vitamin B12 is 95.5%, and the extraction rate (mass fraction, metered by sodium propionate) of propionic acid is 94.7%; and the method is favorable for environmental protection and can increase the production benefit.
2 citations
Patent•
24 Feb 2016
TL;DR: In this article, a carrier-free propionic acid solid feed mildew preventive is presented, which consists of the following materials in parts by mass: 90-100 parts of sodium propionate, 20-77 parts of propionic acyclic acid, 1-3 parts of benzoic acids, 1 -4 parts of sorbic acids and 2-5 parts of Tween 80.
Abstract: The present invention provides a carrier-free propionic acid solid feed mildew preventive and a preparation and a use thereof. The carrier-free propionic acid solid feed mildew preventive consists of the following materials in parts by mass: 90-100 parts of sodium propionate, 20-77 parts of propionic acid, 1-3 parts of benzoic acids, 1-4 parts of sorbic acids and 2-5 parts of Tween 80. The active ingredient content of the carrier-free and propionic acid solid feed mildew preventive is up to 98%. The addition amount is reduced, which can save the use costs of the mildew preventive. The carrier-free propionic acid solid feed mildew preventive not only can be used as a traditional solid mildew preventive, but also can be used as a liquid mildew preventive which can be used by mixing with water. Compared with the existing liquid mildew preventive, the packaging and transportation costs are decreased significantly.
Patent•
09 Nov 2016
TL;DR: In this paper, a preparation method of a compound bacterium capable of quickly removing propionic acid accumulation is presented, which is used for anaerobic digestion technology, particularly to biogas fermentation.
Abstract: The invention provides a preparation method of a compound bacterium capable of quickly removing propionic acid accumulation. The preparation method comprises the following steps: (1) taking effluent of a dextranum wastewater anaerobic digester as an original inoculums, and sodium propionate as a carbon source, and performing inoculated culture till the degradation rate of propionic acid in a culture reaches 50-80% and the content of methane is 30-50%; (2) transferring the object obtained in the step (1) to a fresh culture medium for culture, and adding the following bacteria into every ml of a culture solution of the object obtained in the step (1): (2.5-5)*10 Pelotomaculum schinkii, (1-2.5)*10 Pelotomaculum propionicicum, (1-3)*10 Syntrophobacter wolinii, (0.4-1.4)*10 Methanospirillum hungatei, (0.5-1.4)*10 Methanoculleus palmolei, (0.5-1.4)*10 Methanoculleus bourgensis, (0.5-2.5)*10 Methanosarcina barkeri and (1-3)*10 Methanosarcina mazei; (3) performing airtight culture on the object obtained in the step (2) to obtain the compound bacterium capable of quickly removing propionic acid accumulation. The invention further provides application of the compound bacterium to the anaerobic digestion technology, particularly to biogas fermentation. The compound bacterium can quickly and efficiently remove propionic acid accumulation, and greatly improve the anaerobic digestion efficiency and stability.
TL;DR: In this article, the effects of the addition of precursor on cell growth and the kinetics of aureofuscin production were investigated during submerged cultivation of Str. aureuscus.
Abstract: Aureofuscin is an important tetraene macrolides antibiotic produced in submerged culture by Streptomyces aureofuscus isolated from the soil in China. In the present work, the effects of the addition of precursor on cell growth and the kinetics of aureofuscin production were investigated during submerged cultivation of Str. aureofuscus . The sodium acetate and sodium propionate are more suitable precursor than alcohol, sodium butyrate, n-propanol, n-butanol. The addition of acetate and propionic sodium at a ratio of 5:1 at a total concentration of 1.5mg mL −1 after 24 h showed stimulatory effects on aureofuscin production, reaching 3.708 mg mL −1 (approximately 267% increases in aureofuscin production, compared with the control culture). Moreover , A further enhancement in aureofuscin production was achieved by cultivation in a 5-L stirred-tank bioreactor under controlled pH conditions under the above optimum condition. The optimal fermentation conditions were that 4L/min ventilatory capacity, 220r/min rotational speed, dissolves oxygen not be lower than 20%, fermentation period 84h and pH should control nearby 5.5, and the maximum yield of aureofuscin of 3.99 mg mL −1 was achieved after 84 h When the sodium acetate and sodium propionate were added as a mixture of acetate and propionate at a ratio of 5:1 and a final concentration of 1.5 mg mL −1 after 24 h cultivation.
Patent•
27 Apr 2016
TL;DR: In this paper, an anti-diabetics oral pharmaceutical composition, which consists of the following components: (1) 10-20mg of 5-(3-hydroxy-7-methoxynaphthalen-2-yl)-1,1-dioxo-[1,2,5] thiadiazolidin-3-one potassium salt, (2) 20-30mg of (2S, 3R)-3-cyclopropyl, 3-((S)-2-(2'-fluoro-5'-methoxy
Abstract: The invention discloses an anti-diabetics oral pharmaceutical composition, which consists of the following components: (1) 10-20mg of 5-(3-hydroxy-7-methoxynaphthalen-2-yl)-1,1-dioxo-[1,2,5] thiadiazolidin-3-one potassium salt, (2) 20-30mg of (2S, 3R)-3-cyclopropyl-3-((S)-2-(2'-fluoro-5'-methoxy-[1,1'-biphenyl]-4-yl) chromen-7-yl)-2-methyl sodium propionate, (3) 200-300mg of microcrystalline cellulose, (4) 10-25mg of cross-linked sodium carboxymethyl cellulose, and (5) 1-8mg of magnesium stearate, and the pharmaceutical composition is prepared by combining two active substances of different types; and under the precondition of achieving a same therapeutic effect, the dosage of the active substances of the medicine is reduced by at least 1/2.
Patent•
29 Jun 2016
TL;DR: In this paper, a composition for regulating the electrolyte balance and acid-base balance of the animal organisms is prepared from, by weight, 5%-90% of potassium butyrate and 10%-95% of sodium salt, wherein the sodium salt is physiologically acceptable.
Abstract: The invention belongs to the technical field of animal nutrition, and particularly discloses a composition for regulating electrolyte balance and acid-base balance of animal organisms and application thereof.The composition for regulating the electrolyte balance and acid-base balance of the animal organisms is prepared from, by weight, 5%-90% of potassium butyrate and 10%-95% of sodium salt, wherein the sodium salt is physiologically acceptable and comprises but not limited to one or more of sodium butyrate, sodium sulfate, sodium phosphate, sodium dihydrogen phosphate, sodium hydrogen phosphate, sodium carbonate, sodium bicarbonate, sodium formate, sodium diformate, sodium acetate, sodium diacetate, sodium propionate, sodium succinate, sodium citrate, sodium tartrate, sodium malate, sodium fumarate, sodium maleate, sodium benzoate, sodium sorbate, sodium cinnamate, sodium lactate and sodium taurate.It is found through many years of research that after potassium butyrate is mixed with some special sodium salts according to a certain proportion, the mixture can regulate the electrolyte balance and acid-base balance of the animal organisms, significantly improve the animal health condition and improve the animal production performance.
Patent•
24 Feb 2016
TL;DR: In this article, a method for the preparation of a finishing liquid for a fabric is described, which consists of steps as follows: (1), 1-2 parts by weight of polyethylene glycol bistearate, 1.6 parts of hydroxyl propyl cellulose, 0.8 parts of sodium carbonate and 1.3 parts of bamboo vinegar are sequentially added to 22 parts by mass of deionized water, and the mixture is stirred uniformly.
Abstract: The invention discloses a preparation method of a finishing liquid for a fabric. The preparation method comprises steps as follows: (1), 1-2 parts by weight of polyethylene glycol bistearate, 1.6 parts by weight of hydroxyl propyl cellulose, 0.8 parts by weight of sodium carbonate and 1.3 parts by weight of bamboo vinegar are sequentially added to 22 parts by mass of deionized water, and the mixture is stirred uniformly; (2), 1.5 parts by weight of a purslane herb extract, 0.7 parts by weight of sodium propionate, 1.5 parts by weight of sodium triphosphate and 0.4 parts by weight of zinc hydroxystannate are added simultaneously, the mixture is stirred continuously until the mixture is uniformly mixed, and the finishing liquid is prepared. The prepared finishing liquid has good hydrophilia and good permeability, and the fabric finished with the finishing liquid has excellent flame retardancy, mould-proof performance, mothproof performance, antibacterial performance and anti-static performance and high washability and touches soft.