Sodium propionate

About: Sodium propionate is a research topic. Over the lifetime, 463 publications have been published within this topic receiving 9451 citations. The topic is also known as: E281 & sodium propionate anhydrous.

Use of sodium propionate in external infections of the eyes.

Abstract: The lower fatty acids have recently been shown to be of great value in the treatment of external infections of the eyes. Sodium propionate (C 2 H 5 COONa), the sodium salt of one of these acids, has now been used in about 1,200 patients with infections of the lids, conjunctiva and cornea, and the results obtained compare most favorably with those noted with other antibiotics. Experimental studies have also been made. The drug is virtually nontoxic; it is effective against all the bacteria causing common ocular infections and against fungi, whose importance in blepharitis is now being appreciated, and its use does not result in allergies or sensitivities. These and other advantages will be detailed later. HISTORY OF FATTY ACID THERAPY For the complete history of the development of the medical use of the lower fatty acids the reader is referred to the papers of Peck and Russ 1

Osmotic and activity coefficients of the sodium salts of formic, acetic and propionic acids

Abstract: Osmotic and activity coefficients are reported for the sodium salts of formic, acetic and propionic acids to the limits of their solubilities. Hydration of the “second kind” appears to increase with the length of the hydrocarbon chains. The onset of micelle formation is indicated in the more concentrated sodium propionate solutions.

Effect of propionate on in vivo carbohydrate metabolism in streptozocin-induced diabetic rats.

Abstract: Undigested carbohydrates and some dietary fibers are fermented in the large intestine to form short-chain fatty acids (SCFA), including acetate, propionate, and butyrate. It has been suggested that some of the beneficial effects of high-carbohydrate, high-fiber diets on carbohydrate and lipid metabolism are mediated by the metabolism of SCFA in the liver. Propionate has been shown in vitro to decrease glucose production in rat hepatocytes. The aim of the present study was to investigate the effects of propionate on carbohydrate metabolism in normal and streptozocin (STZ)-induced diabetic male Sprague-Dawley rats. Rats were fed a high-fat diet with or without sodium propionate supplementation (either 0.5% or 5% wt/wt) for 4 weeks. At the completion of the feeding period, body weight and liver glycogen concentrations were significantly decreased in STZ-diabetic rats and were unaffected by propionate supplementation. Although STZ-diabetic animals had elevated fasting plasma glucose, cholesterol, and triglyceride levels relative to nondiabetic rats, propionate supplementation had no significant effect on these parameters in either group. Basal and insulin-stimulated carbohydrate metabolism were assessed using the euglycemic clamp technique in overnight-fasted animals with 3 (H)-6-glucose infusion. As expected, basal hepatic glucose production (HGP) was higher and the metabolic clearance rate of glucose (MCR) was lower in STZ-diabetic rats. High-dose insulin infusion (3 mU · kg −1 · min −1 ) suppressed HGP in nondiabetic and diabetic animals and increased the MCR in nondiabetic animals. However, propionate supplementation did not alter basal or insulin-stimulated HGP or the MCR in either nondiabetic or diabetic animals. It is concluded that oral propionate supplementation had no detectable effect on carbohydrate or lipid metabolism in either nondiabetic or STZ-diabetic rats.