Sodium propionate

About: Sodium propionate is a research topic. Over the lifetime, 463 publications have been published within this topic receiving 9451 citations. The topic is also known as: E281 & sodium propionate anhydrous.

The voluntary intake of hay and silage by lactating cows in response to ruminal infusion of acetate or propionate, or both, with or without distension of the rumen by a balloon.

Abstract: In order to test the hypothesis that negative feedback signals from abdominal receptors are integrated in an additive manner in the control of voluntary food intake, cows with rumen fistulas were given intraruminal infusions of sodium acetate or sodium propionate, or both, with or without distension of the rumen by balloon. Intakes were monitored during the 3 h experimental period and for 2 h after and samples of rumen fluid were taken for estimation of short-chain fatty acid concentrations and osmolality. Six cows in mid-lactation were fed on hay and concentrates and given, into the rumen, 5.5 mol sodium acetate, 5.2 mol sodium propionate and 7.5 l of distension. Compared with the control (water infusion), neither acetate, propionate nor distension significantly depressed hay intake when given separately. When given in combination, however, the following significantly depressed intake during the 3 h treatment period: propionate + distension, acetate + distension, acetate + propionate + distension. Seven cows in early lactation were fed on silage and concentrates and given, into the rumen, 9.0 mol sodium acetate, 4.0 mol sodium propionate and 10.0 litres of distension. Again, none of the three given alone depressed silage intake to a significant extent during the 3 h treatment period, whereas the following combinations had a significant effect: propionate + distension, acetate + distension, acetate + propionate + distension. Basal rumen osmolalities were similar for the two types of feed but infusion of the sodium salts caused a very much greater increase with silage than with hay.(ABSTRACT TRUNCATED AT 250 WORDS)

Acute oral sodium propionate supplementation raises resting energy expenditure and lipid oxidation in fasted humans

Abstract: Short chain fatty acids (SCFAs), produced from fermentation of dietary fibre by the gut microbiota, have been suggested to modulate energy metabolism. Previous work using rodent models have demonstrated that oral supplementation of the SCFA propionate raises resting energy expenditure (REE) by promoting lipid oxidation. The objective of this study was to investigate the effects of oral sodium propionate on REE and substrate metabolism in humans. Eighteen healthy volunteers (9 females and 9 males; Age: 25±1 y; Body Mass Index: 24.1±1.2 kg/m2) completed two study visits following an overnight fast. Tablets containing a total of 6845mg sodium propionate or 4164mg sodium chloride were provided over the 180 min study period in a random order. REE and substrate oxidation was assessed by indirect calorimetry. Oral sodium propionate administration increased REE (0.045±0.020 kcal/min; P=0.036) accompanied with elevated rates of whole-body lipid oxidation (0.012 ± 0.006 g/min; P=0.048) and independent of changes in glucose and insulin concentrations. Future studies are warranted to determine whether the acute effects of oral sodium propionate on REE translate into positive improvements in long-term energy balance in humans.

Effects of Low Dissolved-Oxygen Concentrations on Poly-(3-Hydroxybutyrate-co-3-Hydroxyvalerate) Production by Alcaligenes eutrophus.

Abstract: The bacterial copolyester poly-(3-hydroxybutyrate-co-3-hydroxyvalerate) was produced with Alcaligenes eutrophus DSM 545 from glucose and sodium propionate in a fed-batch fermentation with both nitrogen limitation and low dissolved-oxygen concentrations. When the dissolved-oxygen content was kept between 1 and 4% of air saturation during the polymer accumulation phase, the yield of 3-hydroxybutyrate (3HB) monomer from glucose was not affected, but the propionate-to-3-hydroxyvalerate (3HV) monomer yield was two to three times (0.48 to 0.73 mol of 3HV mol of propionate consumed(sup-1)) that observed in a control experiment (0.25 mol mol(sup-1)), where the accumulation-phase dissolved-oxygen concentration was 50 to 70% of air saturation. The overall polymer productivity of the fermentation was somewhat decreased by low dissolved-oxygen contents, owing to a slower 3HB production rate. The effect of a low dissolved-oxygen concentration is probably attributable to a reduction of the oxygen-requiring decarbonylation of propionyl-coenzyme A (CoA) to acetyl-CoA.

Responses in the voluntary intake of hay or silage by lactating cows to intraruminal infusions of sodium acetate or sodium propionate, the tonicity of rumen fluid or rumen distension

Abstract: Rumen-fistulated lactating cows were individually fed on hay or silage and intakes were monitored during 3 h treatment periods and for 2 h after. Each experiment used five, six or seven animals and the treatments were applied in a Latin Square design. Sodium acetate infusions of 1·8–11·0 mol in 4.5 litres water caused a dose-related depression in hay intake, the extent being 82 g dry matter (DM)/mol infused (P < 0·01). Sodium acetate infusions of 6·0–15·0 mol in 4·5 litres water caused a dose-related depression in silage intake of 118 g DM/mol infused. Rumen fluid pH for both diets was unaffected by treatment. Acetate and Na concentrations were increased and significantly negatively correlated with intake of both diets. Infusions of 2–8 mol sodium propionate caused a dose-related depression of hay intake which was significant when cow and day effects were accounted for. Sodium propionate infusions of 4–8 mol significantly depressed silage intake by 140 g DM/mol infused (P < 0·001). Rumen fluid pH was unaffected by treatment while propionate and Na concentrations were elevated and significantly negatively correlated with intake for both diets. Inflation of a rubber balloon in the rumen with 12.5–20 litres warm water resulted in a dose-dependent depression in hay intake of 66 g DM/1 distension (P < 0·05). There was significant overeating during the 2 h following the 20 litre treatment. With silage, 15–25 litres of balloon distension for 3 h resulted in a dose-dependent depression in intake of 28 g DM/l distension (P < 0·001). There was no significant overeating during the 2 h following distension. When given in physiological amounts, at the lower end of the range used in these experiments, acetate, propionate and distension of the rumen did not significantly affect hay intakes. However, in each case the linear relationship between intake depression and level of treatment suggested that these factors could contribute to the control of feed intake.