Topic
Sodium sulfide
About: Sodium sulfide is a research topic. Over the lifetime, 2851 publications have been published within this topic receiving 27733 citations. The topic is also known as: disodium sulfide.
Papers published on a yearly basis
Papers
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TL;DR: In this article, basic aluminum oxide and Amberlyst A27 (Cl - form) ion exchange resin, in their original form, were used to catalyze the solid-liquid reactions of benzyl chloride/p-chlorobenzyl chloride with sodium sulfide.
Abstract: Basic aluminum oxide and Amberlyst A27 (Cl - form) ion exchange resin, in their original form, were used to catalyze the solid-liquid reactions of benzyl chloride/p-chlorobenzyl chloride with sodium sulfide. At a 5% loading of the catalysts, enhancement factors of 14 and 25 were obtained for the benzyl chloride reaction with alumina and Amberlyst A27, respectively. Alumina was also used as a cocatalyst with tetrabutylammonium bromide (TBAB) as a homogeneous-phase-transfer catalyst. Enhancement factors as high as 1.9×10 3 and 4.9×10 2 were obtained with benzyl chloride and p-chlorobenzyl chloride, respectively, as organic substrates at a 0.4% loading of TBAB and 5% loading of alumina. Ultrasound was also found to intensify the reaction
23 citations
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TL;DR: The present work was designed to study the effect of sodium sulfide, a donor of H2S, on acute cerebral ischemia.
Abstract: Summary
Aims
Acute cerebral ischemia may lead to ischemic stroke, which is a major cause of death and disability worldwide. Hydrogen sulfide (H2S) functions importantly in mammalian systems. The present work was designed to study the effect of sodium sulfide, a donor of H2S, on acute cerebral ischemia.
Methods
Acute cerebral focal ischemia was produced by middle cerebral artery occlusion (MCAO) in Sprague-Dawley (SD) rats. Bilateral vertebral arteries and common carotid arteries were blocked to establish cerebral global ischemia in SD rats. Acute cerebral anoxia was produced by hypobaric anoxia in C57BL/6 mice and hypoxic anoxia in SD rats. Nimodipine and aspirin were set as positive control separately.
Results
Infarct size after MCAO was decreased by sodium sulfide. Sodium sulfide improved cerebral energy metabolism after cerebral global ischemia and prolonged survival time of animals with acute cerebral anoxia. In addition, increased cerebral blood flow and decreased cerebrovascular resistance, blood viscosity, and thrombogenesis were observed in animals treated with sodium sulfide. In cultured neurons, sodium sulfide increased cell viability and decreased cell apoptosis induced by oxygen-glucose deprivation.
Conclusion
Sodium sulfide, a H2S donor, presents protective effect on acute cerebral ischemia, and might be a promising therapeutic drug.
23 citations
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TL;DR: Hydrogen peroxide-induced mutagenesis and killing of S. typhimurium strain TA102 in the presence of sulfide may in part be explained by an inactivation of catalase by sulfide.
Abstract: The lethal and mutagenic effects of hydrogen peroxide were studied in exponentially growing cultures of Salmonella typhimurium strain TA102. Exposure of the cultures to non-lethal levels of sodium sulfide significantly increased the lethality and mutagenicity of hydrogen peroxide. The catalase activity was decreased in cells exposed to sodium sulfide, but there were no changes in the cellular levels of superoxide dismutase, glutathione reductase, or NADPH-dependent alkyl hydroperoxide reductase. Hydrogen peroxide-induced mutagenesis and killing of S. typhimurium strain TA102 in the presence of sulfide may in part be explained by an inactivation of catalase by sulfide.
23 citations
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TL;DR: The first total synthesis and structural determination of (+)-BE-52440A have been achieved by enantiodivergent synthesis as mentioned in this paper, and the structure of the structure was determined to be the kalafungin type pyranonaphthoquinone.
23 citations
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TL;DR: In this paper, the results indicate that pyrrhotite used during leaching can effectively facilitate the leaching out of manganese, cobalt and nickel, and the final maximum recovery rates for manganese, Co and Ni are 85, 75% and 78% respectively.
23 citations