Showing papers on "Solid lipid nanoparticle published in 1996"
TL;DR: The ability of tristearin, tripalmitin, trimyristin and trilaurin to form solid lipid nanoparticles after melt-homogenization is investigated by DSC and X-ray diffraction.
375 citations
TL;DR: In this article, particle internalization by granulocytes was followed using luminol enhanced chemiluminescence (CL) to assess their toxicological acceptance as intravenous formulation for magnetic resonance imaging and as potential carrier for drug targeting.
241 citations
TL;DR: Solid Lipid Nanoparticles (SLN) as discussed by the authors can be used as a drug reservoir providing controlled drug release by melting the lipid matrix material and dissolving the drug in the melted lipid.
237 citations
TL;DR: The modified SLN proved more efficient in avoiding phagocytic uptake than polystyrene particles surface-modified with these blockcopolymers and to be 10 fold less cytotoxic than polylactide nanoparticles and 100 fold less than butylcyanoacrylate particles.
Abstract: Solid lipid nanoparticles (SLN) as alternative intravenous colloidal drug carriers were produced by high pressure homogenisation of melted lipids (glycerolbehenate, cetylpalmitate). Their surface was modified by using hydrophilic poloxamine 908 and poloxamer 407 block-copolymers in order to reduce the phagocytic uptake by the reticuloendothelial system (RES) after i. v. injection. The phagocytosis reducing effect of the polymers was investigated in vitro in cultures of human granulocytes, uptake was quantified by chemiluminescence. Modification of the SLN with poloxamine 908 and poloxamer 407 reduced the phagocytic uptake to appr. 8–15% compared to the phagocytosis of hydrophobic polystyrene particles. The modified SLN proved more efficient in avoiding phagocytic uptake than polystyrene particles surface-modified with these blockcopolymers (48% and 38%, respectively). Viability determinations revealed the SLN to be 10 fold less cytotoxic than polylactide nanoparticles and 100 fold less than butylc...
214 citations
TL;DR: The dominating effect of the surfactant can be exploited to design SLN with optimum degradation velocity and matrix-controlled drug release-independent on the nature of the lipid matrix.
153 citations
TL;DR: It is conceivable that the fast initial drug release during in vitro dissolution tests takes place by drug release of the outer non-crystalline layers of the particles.
Abstract: Purpose. Solid Lipid Nanoparticles (SLN) are an alternative carrier system for the controlled delivery of drugs. In most cases prednisolone loaded SLN show a biphasic release behaviour. The initial phase is characterised by a fast drug release, which is followed by a sustained drug release over several weeks.
Methods. The particles are produced by high pressure homogenisation of a lipid (e.g. compritol, cholesterol) dispersed in an aqueous surfactant solution. In this study atomic force microscopy was used to image the original unaltered shape and surface properties of the particles. The crystallinity of the nanoparticles was investigated by differential scanning calorimetry.
Results. The AFM investigations revealed the disc like shape of the particles. From differential scanning calorimetry data it can be concluded that the particle core is in the crystalline state. Additionally it was proven that the particles are surrounded by a soft layer.
Conclusions. Thus it is conceivable that the fast initial drug release during in vitro dissolution tests takes place by drug release of the outer non-crystalline layers of the particles. The following sustained drug release can be assigned to the predisolone release of the inner crystalline particle layers.
148 citations
Journal Article•
TL;DR: In this article, tripalmitate dispersions display narrow monomodal size distributions, ranging from approximately 30 to 100 nm depending on the lecithin/co-surfactant blend.
135 citations
TL;DR: In vitro release of thymopentin from the solid lipid nanoparticles followed a pseudo-zero-order kinetics and the incorporation of the hydrophilic drug was 5.2% and 1.7% respectively.
115 citations
Journal Article•
TL;DR: In this paper, a simple device to form solid lipid nanoparticles from warm O/W microemulsions was developed, where precise control of temperature, drop dimensions and delivery rate of the microemulsion was achieved, obtaining reproducible nanoparticle dispersions.
92 citations
TL;DR: The results obtained suggest that the formation of multiple PL bilayers is probable in SLN's prepared with a high molar ratio of PL to TL, significantly higher than the theoretical amount required to form a single monolayer on the surface.
Abstract: Purpose. Solid lipid nanoparticles (SLN) are comprised of a high-melting point triglyceride (TG) core with a phospholipid (PL) coating. This study has investigated the possible formation of multiple PL bilayers on the TG core of SLN's as a function of increasing the PL:TG molar ratio.
78 citations
01 Jan 1996
TL;DR: By decreasing the particle size and increasing the surfactant concentration, the release rate was increased especially in the case of highly lipophilic drug loaded SLN, which showed a distinctly prolonged release over a few days.
Abstract: Solid lipid nanoparticles(SLN) are particulate systems for parenteral drug administration and suitable for controlled release. SLN were prepared by homogenization process. Dispersion at increased temperature (molten lipid) was performed to yield SLN loaded with lipophilic drugs. Tetracaine base, lidocaine base, prednisolone, methyltestosterone and ethinylestradiol were used as model drugs to access the loading capacity and to study the release behavior. To investigate production parameters(lipids, surfactant concentration, homogenizing rpm) in the formation of SLN, particle size was performed by laser diffraction analysis. The mean particle size of SLN with stearic acid or trilaurin was below 1 micron. By decreasing the particle size and increasing the surfactant concentration, the release rate was increased especially in the case of highly lipophilic drug loaded SLN. Methyltestosterone or ethinylestradiol loaded SLN showed a distinctly prolonged release over a few days.
Patent•
12 Jul 1996TL;DR: In this article, a detergent is used to solubilize the lipid bilayers, liposomes, or lipid complexes at acceptable lipid concentrations, forming micelles therefrom which contain lipid bilayer, lipid polymers, lipid complex lipid, detergent and endotoxin, should it be present.
Abstract: Endotoxin incorporated into liposomes, lipid bilayers or lipid complexes can be detected by combining an aqueous suspension of the liposomes, lipid complexes or lipid bilayers with a suitable detergent. Preferable detergents, e.g., Lubrol-PX™ or a polyoxyethylene ether, solubilize the lipid bilayers, liposomes or lipid complexes at acceptable lipid concentrations, forming micelles therefrom which contain lipid bilayer, liposome or lipid complex lipid, detergent and endotoxin, should it be present. The micelles are then assayed for the presence of endotoxin.
Journal Article•
TL;DR: By decreasing the particle size and increasing the surfactant concentration, the release rate was increased especially in the case of highly lipophilic drug loaded SLN, which showed a distinctly prolonged release over a few days.
Abstract: Solid lipid nanoparticles(SLN) are particulate systems for parenteral drug administration and suitable for controlled release. SLN were prepared by homogenization process. Dispersion at increased temperature (molten lipid) was performed to yield SLN loaded with lipophilic drugs. Tetracaine base, lidocaine base, prednisolone, methyltestosterone and ethinylestradiol were used as model drugs to access the loading capacity and to study the release behavior. To investigate production parameters(lipids, surfactant concentration, homogenizing rpm) in the formation of SLN, particle size was performed by laser diffraction analysis. The mean particle size of SLN with stearic acid or trilaurin was below 1 micron. By decreasing the particle size and increasing the surfactant concentration, the release rate was increased especially in the case of highly lipophilic drug loaded SLN. Methyltestosterone or ethinylestradiol loaded SLN showed a distinctly prolonged release over a few days.