Topic
Solid lipid nanoparticle
About: Solid lipid nanoparticle is a research topic. Over the lifetime, 3175 publications have been published within this topic receiving 127912 citations. The topic is also known as: LNP & SLN.
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TL;DR: Fucose decorated SLNs showed promising results to develop therapeutic interventions for breast cancer, and paved a way to explore this promising and novel nano-carrier which enables to address breast cancer.
75 citations
TL;DR: This study seeks to cover the important challenges of lipid-based nanocarriers including structures and characteristics, properties, production methods, advantages and drawbacks, and their applications to encapsulate antibacterial compounds effectively, particularly in food systems.
75 citations
TL;DR: Results revealed rapid ALM brain delivery of the optimized formula, and toxicological results confirmed the safety of NF for nasal administration, encouraging for further clinical trials of the developed system in humans in future research.
75 citations
Patent•
14 Oct 2005TL;DR: In this paper, the authors proposed functionalized solid lipid nanoparticles comprising a neutral lipid and a first functionalized polymer comprising at least one ionic or ionizable moiety and methods for providing same.
Abstract: In one aspect, the invention relates to functionalized solid lipid nanoparticles comprising a neutral lipid and a first functionalized polymer comprising at least one ionic or ionizable moiety and methods for providing same. In a further aspect, the invention relates to tumor targeting therapeutic systems, multimodal diagnostic therapeutic systems, thermoresponsive payload delivery systems, magnetic-driven targeting systems, therapeutic diagnostic systems, stabilized ink compositions, and cosmetic formulations comprising the solid lipid nanoparticles of the invention. In a further aspect, the invention relates to methods of delivering at least one biologically active agent, pharmaceutically active agent, magnetically active agent, or imaging agent across the blood-brain barrier, across a cellular lipid bilayer and into a cell, and to a subcellualr structure. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
75 citations
TL;DR: HPMC transdermal film-loaded AVA SLNs is an effective and alternative to per-oral drug administration and significantly affected by lipid concentration and % of cholesterol.
Abstract: Context: Avanafil (AVA) is used in the treatment of erectile dysfunction, but is reported for its poor aqueous solubility. Solid lipid nanoparticles (SLNs) are lipid carriers that can greatly enhance drug solubility and bioavailability.Objective: This work was aimed to formulate and optimize AVA SLNs with subsequent loading into hydrogel films for AVA transdermal delivery.Materials and methods: AVA SLNs were prepared utilizing homogenization followed by ultra-sonication technique. The prepared SLNs were characterized for particle size, charge, surface morphology and drug content. The optimized SLNs formulation was incorporated into transdermal films prepared using HPMC and chitosan. Hydrogel films were evaluated for ex-vivo rat skin permeation using automated Franz diffusion cells. The permeation parameters and the release mechanism were evaluated. The transdermal permeation of the prepared AVA SLNs through the skin layers was studied using confocal laser scanning microscope.Results: Lipid concent...
75 citations