scispace - formally typeset
Search or ask a question
Topic

Solid lipid nanoparticle

About: Solid lipid nanoparticle is a research topic. Over the lifetime, 3175 publications have been published within this topic receiving 127912 citations. The topic is also known as: LNP & SLN.


Papers
More filters
Journal ArticleDOI
TL;DR: The preparation of SLN was optimized for various formulation variables including type and quantity of lipid, surfactant, amount of co-surfactant and volume of organic phase and effect of variables related to homogezation, sonication and stirring processes was determined and optimized.

69 citations

Journal ArticleDOI
TL;DR: After an in vitro-in vivo evaluation of piribedil solid lipid particles developed for Parkinson's disease therapy, it has been determined that release rate could be controlled and piribingil bioavailability could be improved.
Abstract: Modification of the dissolution rate and, thus, the enhancement of the bioavailability of a dopaminergic drug, piribedil, which has a low aqueous solubility and short elimination half-life have been the aim in this study. Preparations of micron and submicron particles using solid lipid carriers have been performed for this purpose. For the avoidance of solvent residues resulting from the preparation technique, cold and hot homogenization methods have been used to prepare solid lipid particles. After obtaining an appropriate particle size, piribedil loading and preparation yield by the use of those two methods, various formulations have been prepared with different lipid, drug and surfactant materials. The factors mentioned were found to affect properties of the particles, and the release rate was found to be the fastest in acidic medium. Suspensions of pure piribedil and a formulation, selected according to the results obtained from in vitro dissolution and particle size experiments, were compared using t...

69 citations

Journal ArticleDOI
TL;DR: The solid lipid nanoparticles (SLNs) showed clear zone of inhibition against Aspergillus flavus indicating antimicrobial efficacy of formulations, and stearic acid-SLNs showed higher entrapment of drug compared with palmitic acid -SLNs.
Abstract: The purpose of this study was to investigate the feasibility of entrapping water-insoluble drug itraconazole into solid lipid nanoparticles (SLNs) for topical ocular delivery The drug-loaded SLNs were prepared from stearic acid and palmitic acid using different concentrations of polyvinyl alcohol employed as emulsifier SLNs were prepared by the melt-emulsion sonication and low temperature-solidification method and characterized for particle size, zeta potential, drug loading and drug entrapment efficiency The mean particle size of SLNs prepared with stearic acid ranged from 139 to 199 nm, while the SLNs prepared with palmitic acid had particle size in the range of 126-160 nm The SLNs were spherical in shape Stearic acid-SLNs showed higher entrapment of drug compared with palmitic acid-SLNs Differential scanning calorimetry (DSC) and X-ray diffraction measurements showed decrease in crystallinity of drug in the SLN formulations The modified Franz-diffusion cell and freshly excised goat corneas were used to test drug corneal permeability Permeation of itraconazole from stearic acid-SLNs was higher than that obtained with palmitic acid-SLNs The SLNs showed clear zone of inhibition against Aspergillus flavus indicating antimicrobial efficacy of formulations

68 citations

Journal ArticleDOI
TL;DR: The results suggest that the SLN tested could be an interesting carrier for IDE targeting to the upper skin layers by topical application of IDE-loaded solid lipid nanoparticles (SLN).

68 citations

Journal ArticleDOI
TL;DR: A brief introduction to the history of antimicrobial lipids and their current status and challenges is provided, and a detailed discussion of ongoing research efforts to develop nanotechnology formulations of fatty acids and monoglycerides that enable superior in vitro and in vivo performance is presented.
Abstract: Free fatty acids and monoglycerides have long been known to possess broad-spectrum antibacterial activity that is based on lytic behavior against bacterial cell membranes. Considering the growing challenges of drug-resistant bacteria and the need for new classes of antibiotics, the wide prevalence, affordable cost, and broad spectrum of fatty acids and monoglycerides make them attractive agents to develop for healthcare and biotechnology applications. The aim of this review is to provide a brief introduction to the history of antimicrobial lipids and their current status and challenges, and to present a detailed discussion of ongoing research efforts to develop nanotechnology formulations of fatty acids and monoglycerides that enable superior in vitro and in vivo performance. Examples of nano-emulsions, liposomes, solid lipid nanoparticles, and controlled release hydrogels are presented in order to highlight the potential that lies ahead for fatty acids and monoglycerides as next-generation antibacterial solutions. Possible application routes and future directions in research and development are also discussed.

68 citations


Network Information
Related Topics (5)
Drug carrier
18.2K papers, 997.7K citations
90% related
Drug delivery
49.7K papers, 1.8M citations
90% related
Micelle
35.1K papers, 1M citations
79% related
Self-healing hydrogels
34.9K papers, 1.2M citations
77% related
Nanoparticle
85.9K papers, 2.6M citations
76% related
Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023193
2022446
2021242
2020254
2019237
2018226