Topic
Solid lipid nanoparticle
About: Solid lipid nanoparticle is a research topic. Over the lifetime, 3175 publications have been published within this topic receiving 127912 citations. The topic is also known as: LNP & SLN.
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TL;DR: A review of different approaches that have been used for the delivery of hydrophilic drugs using solid lipid nanoparticles (SLNs) is presented in this article, which not only discusses various modifications in the traditional methods for the synthesis but also emphasizes modifications of the drugs itself that can help in their efficient entrapment into SLNs drug carriers.
64 citations
TL;DR: The model hydrophilic drug-DS can be formulated into the SLNs with the help of PCs and some weak interactions between DS and lipid materials might take place during the preparation of SLNs.
Abstract: To successfully prepare the diclofenac sodium (DS)-loaded solid lipid nanoparticles (SLNs), phospholipid complexes (PCs) technology was applied here to improve the liposolubility of DS. Solid lipid nanoparticles (SLNs) loaded with phospholipid complexes (PCs) were prepared by the modified emulsion/solvent evaporation method. DS could be solubilized effectively in the organic solvents with the existence of phospholipid and apparent partition coefficient of DS in PCs increased significantly. X-ray diffraction analysis suggested that DS in PCs was either molecularly dispersed or in an amorphous form. However, no significant difference was observed between the Fourier transform infrared spectroscopy (FT-IR) spectra of physical mixture and that of PCs. Particles with small sizes, narrow polydispersity indexes and high entrapment efficiencies could be obtained with the addition of PCs. Furthermore, according to the transmission electron microscopy, a core-shell structure was likely to be formed. The presence of PCs caused the change of zeta potential and retarded the drug release of SLNs, which indicated that phospholipid formed multilayers around the solid lipid core of SLNs. Both FT-IR and differential scanning calorimetry analysis also illustrated that some weak interactions between DS and lipid materials might take place during the preparation of SLNs. In conclusion, the model hydrophilic drug-DS can be formulated into the SLNs with the help of PCs.
64 citations
TL;DR: Different techniques used to produce SLN and NLC with potential or effective peptide encapsulation are outlined and basic principles of covalent and non-covalent lipidization are described and discussed as a prerequisite to improve hydrophilic peptides encapsulation in lipid-based nanosuspensions.
64 citations
TL;DR: Solid lipid nanoparticles decorated with angiopep‐2 can be an excellent option as targeted drug delivery system for antiglioma therapy, indicated.
64 citations
TL;DR: There was no interaction of PPN with lipid and PPN was well dispersed in the lipid matrix without any crystallization and the entrapment efficiency of this system was found to be 55% with 4.15% of drug loading in lipid matrix.
64 citations