Topic
Solid lipid nanoparticle
About: Solid lipid nanoparticle is a research topic. Over the lifetime, 3175 publications have been published within this topic receiving 127912 citations. The topic is also known as: LNP & SLN.
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TL;DR: This review gives an overview of LNPs, including their physico-chemical properties and pharmacological uses, and highlights the most important innovations in the preparation techniques, aimed to encapsulate different molecules within the lipid matrix.
Abstract: Introduction: Nanoparticles are rapidly developing as drug carriers because of their size-dependent properties. Lipid nanoparticles (LNPs) are widely employed in drug delivery because of the biocompatibility of the lipid matrix. Areas covered: Many different types of LNPs have been engineered in the last 20 years, the most important being solid lipid nanoparticles (SLNs), nanostrucured lipid carriers (NLCs), lipid–drug conjugates (LDCs) and lipid nanocapsules (LNCs). This review gives an overview of LNPs, including their physico-chemical properties and pharmacological uses. Moreover, it highlights the most important innovations in the preparation techniques of LNPs, aimed to encapsulate different molecules within the lipid matrix. Finally, it gives a short perspective on the challenges of drug delivery, which are a potential field of application for LNPs: cancer therapy, overcoming the blood–brain barrier and gene and protein delivery. Expert opinion: LNPs are a safe and versatile vehicles for drug and ac...
272 citations
TL;DR: Ex vivo skin studies revealed that NLC are more efficient in carrying RSV to the epidermis, and RSV-loaded NLC with smaller PS and higher drug loading appears to be superior to SLN for dermal applications.
Abstract: Background
Excessive generation of radical oxygen species (ROS) is a contributor to skin pathologies. Resveratrol (RSV) is a potent antioxidant. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) can ensure close contact and increase the amount of drug absorbed into the skin. In this study, RSV was loaded into SLN and NLC for dermal applications.
271 citations
TL;DR: The review focuses on the biological and biopharmaceutical issues to be considered in the design of delivery strategy for treating parasitic infections and describes the role of the colloidal carriers liposomes, polymeric nanoparticles, lipid nanoparticles in optimizing the delivery of anti-malarial, anti-leishmanial and anti-trypanosomial agents.
266 citations
TL;DR: Aqueous dispersions of solid lipid nanoparticles (SLNTM) were converted by spray-drying into dry, reconstitutable powders which could be stored over a long period and were still acceptable for i.v. administration with respect to the particle size distribution and toxicity.
266 citations
Journal Article•
TL;DR: Results demonstrated that SLN promote the oral absorption of insulin, and the potential of these colloidal carriers for oral administration was evaluated.
Abstract: The aim of this work was to produce and characterize cetyl palmitate-based solid lipid nanoparticles (SLN) containing insulin, and to evaluate the potential of these colloidal carriers for oral administration. SLN were prepared by a modified solvent emulsification-evaporation method based on a w/o/w double emulsion. The particle size, zeta potential and association efficiency of unloaded and insulin-loaded SLN were determined and were found to be around 350 nm, negatively charged and the insulin association efficiency was over 43%. After oral administration of insulin-loaded SLN to diabetic rats, a considerable hypoglycemic effect was observed during 24 hours. These results demonstrated that SLN promote the oral absorption of insulin.
264 citations