Topic
Solid lipid nanoparticle
About: Solid lipid nanoparticle is a research topic. Over the lifetime, 3175 publications have been published within this topic receiving 127912 citations. The topic is also known as: LNP & SLN.
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TL;DR: It is demonstrated that, despite the drug’s affinity to lipids frequently used in SLN production, the curcumin amount loaded in most SLN formulations may be too low to exhibit anticancer properties, substantiating the conclusions thatCurcumin's effect in cancer cells is highly dose dependent.
Abstract: Curcumin, a phenolic compound from turmeric rhizome (Curcuma longa), has many interesting pharmacological effects, but shows very low aqueous solubility. Consequently, several drug delivery systems based on polymeric and lipid raw materials have been proposed to increase its bioavailability. Solid lipid nanoparticles (SLN), consisting of solid lipid matrix and a surfactant layer can load poorly water-soluble drugs, such as curcumin, deliver them at defined rates and enhance their intracellular uptake. In the present work, we demonstrate that, despite the drug’s affinity to lipids frequently used in SLN production, the curcumin amount loaded in most SLN formulations may be too low to exhibit anticancer properties. The predictive curcumin solubility in solid lipids has been thoroughly analyzed by Hansen solubility parameters, in parallel with the lipid-screening solubility tests for a range of selected lipids. We identified the most suitable lipid materials for curcumin-loaded SLN, producing physico...
41 citations
TL;DR: SPG membrane emulsification is an interesting alternative method to high-pressure homogenization for lipid nanoparticle dispersions due to the comparatively lower process pressures of at maximum 10bar.
41 citations
01 Jan 2013
TL;DR: In this article, the chemical structure, production methodology, and physicochemical characterization of solid lipid nanoparticles (SLN) have been systematically discussed, and the key points that may limit the clinical use of SLN are addressed.
Abstract: Solid lipid nanoparticles (SLN™) are a new generation of drug delivery systems being exploited for several drugs since the nineties. These particles can be composed of different types of solid lipids, such as glycerides, waxes, and fatty acids, and stabilized by a wide range of surfactants. In the present chapter, the chemical structure, production methodology, and physicochemical characterization are systematically discussed. Parameters such as particle size, distribution, polymorphic behaviour, and crystallization are required to characterize SLN and may predict their in vitro stability and in vivo profile, therefore structural parameters can influence the biopharmaceutical properties. The use of SLN for drug delivery is also dependent on their toxicological profile in vitro. Nanotoxicology is also discussed addressing the key points that may limit the clinical use of SLN.
41 citations
TL;DR: The high loading values and low burst effect observed for these DEX palmitate-containing nanoparticles in addition to their stealth properties are expected to allow for the delivery of sufficient amounts of DEX to tumors to enhance the uptake of chemotherapeutic agents.
Abstract: The pre-administration of dexamethasone (DEX) has previously been shown to enhance the anti-tumor efficacy of chemotherapeutic agents. The delivery of anti-inflammatory agents specifically to tumors via nanoparticle carriers is expected to promote the effectiveness of chemotherapeutic agents while avoiding systemic toxicities. The process for preparing solid lipid nanoparticles containing anti-inflammatory agents using the nanotemplate engineering method was optimized. Due to the solubilization of DEX in the bulk aqueous phase, its more lipophilic palmitate ester was synthesized and incorporated in nanoparticles that included a pegylating agent, PEG6000 mono-stearate, as part of the formulation. The stealth properties of these nanoparticles were demonstrated to be enhanced compared to latex particles by measuring the adsorption of radioiodinated IgG (185 μg vs. 6.7 μg IgG/mg NP). In addition, the uptake of 14C-labeled nanoparticles by murine macrophages was shown to decrease from 36.6% to 14.7% of the nanoparticles/mg cell protein as the amount of pegylating agent in the formulation increased from 0 to 4 mg/mL. The high loading values and low burst effect observed for these DEX palmitate-containing nanoparticles in addition to their stealth properties are expected to allow for the delivery of sufficient amounts of DEX to tumors to enhance the uptake of chemotherapeutic agents.
41 citations
TL;DR: In vivo evaluations, it was demonstrated that the memory was significantly restored in cognitive deficit rats treated with EPO-SLN compared to the Rats treated with native drug using the Morris water maze test.
41 citations