Topic
Solid lipid nanoparticle
About: Solid lipid nanoparticle is a research topic. Over the lifetime, 3175 publications have been published within this topic receiving 127912 citations. The topic is also known as: LNP & SLN.
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TL;DR: Treatment of the OVCAR-3 human ovarian cancer cell line and the MCF-7 breast cancer cell lines with paclitaxel-loaded SLNs yielded cytotoxicities comparable to those of a commercially available Cremophor EL-based pac litaxel formulation, suggesting that the optimized SLN formulation may have a potential as alternative delivery system for parenteral administration of paclitxel.
217 citations
TL;DR: It is suggested that SLNs could be used as a potential carrier for pulmonary delivery of insulin by improving both in vitro and in vivo stability as well as prolonging hypoglycemic effect, which inevitably resulted in enhanced bioavailability.
216 citations
TL;DR: This investigation demonstrated the superiority of NLC over SLN for improved oral delivery and it was deduced that the liquid lipid, oleic acid was the principal formulation factor responsible for the improvement in characteristics, pharmacokinetics and biodistribution of N LCs.
215 citations
TL;DR: The modified SLN proved more efficient in avoiding phagocytic uptake than polystyrene particles surface-modified with these blockcopolymers and to be 10 fold less cytotoxic than polylactide nanoparticles and 100 fold less than butylcyanoacrylate particles.
Abstract: Solid lipid nanoparticles (SLN) as alternative intravenous colloidal drug carriers were produced by high pressure homogenisation of melted lipids (glycerolbehenate, cetylpalmitate). Their surface was modified by using hydrophilic poloxamine 908 and poloxamer 407 block-copolymers in order to reduce the phagocytic uptake by the reticuloendothelial system (RES) after i. v. injection. The phagocytosis reducing effect of the polymers was investigated in vitro in cultures of human granulocytes, uptake was quantified by chemiluminescence. Modification of the SLN with poloxamine 908 and poloxamer 407 reduced the phagocytic uptake to appr. 8–15% compared to the phagocytosis of hydrophobic polystyrene particles. The modified SLN proved more efficient in avoiding phagocytic uptake than polystyrene particles surface-modified with these blockcopolymers (48% and 38%, respectively). Viability determinations revealed the SLN to be 10 fold less cytotoxic than polylactide nanoparticles and 100 fold less than butylc...
214 citations
TL;DR: In this article, the pros and cons of using solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) in the food industry are discussed.
Abstract: Background Lipid nanoparticles are innovative delivery systems, which are similar to the prevalently used emulsions, with the differences in size and structure in which the water-insoluble core is dispersed in a combination of solid and liquid lipids stabilized by surfactants. Solid lipid nanoparticles (SLNs) plus nanostructured lipid carriers (NLCs) are novel and promising nano-vehicles, which are of great interest to be applied in the food sector owing to their exclusive properties, as investigated in this revision. Scope and approach LNs and NLCs are produced to unite the advantages of structures like liposomes and emulsions and they can be formulated to achieve desirable protection and release of food bioactive ingredients. This review highlights the pros and cons of using SLNs and NLCs in the food industry. Furthermore, the commonly applied production methods and formulations along with the recently conducted studies in the field of food science and technology are underlined. Key findings and conclusions These nano-vehicles have the potential to be employed in the food industrial applications in regard to their beneficial properties like simple production technology, low cost and scale up ability. These nanocarriers have been mostly applied in the pharmaceutical industries and are recently being utilized in the food sector, which seems to have great impacts on this industry as well as their commercialization in the near future.
214 citations