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Solid lipid nanoparticle

About: Solid lipid nanoparticle is a research topic. Over the lifetime, 3175 publications have been published within this topic receiving 127912 citations. The topic is also known as: LNP & SLN.


Papers
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Journal ArticleDOI
TL;DR: DSC and PXRD analysis showed that clozapine is dispersed in SLN in an amorphous state and the release pattern of drug is analyzed and found to follow Weibull and Higuchi equations.

518 citations

Journal ArticleDOI
TL;DR: The present state of the art of lipid based carriers including nanoemulsions, nanoliposomes, solid lipid nanoparticles (SLNs) and novel generation of encapsulation system namely nanostructure lipid carriers (NLCs) are reviewed regarding their production method, physicochemical properties, functionalities, stabilization techniques, potential advantages and limitations and delivery mechanisms.
Abstract: Nanoencapsulation allows protection of the sensitive bioactive food ingredients from unfavorable environmental conditions, eradication of incompatibilities, solubilization, or masking of unpleasant taste or odor. This paper reviews the present state of the art of lipid based carriers including nanoemulsions, nanoliposomes, solid lipid nanoparticles (SLNs) and novel generation of encapsulation system namely nanostructure lipid carriers (NLCs) regarding their production method, physicochemical properties, functionalities, stabilization techniques, potential advantages and limitations and delivery mechanisms. In the last section, mathematical models for predication of bioactive release kinetics from lipid based nanocarriers, which can be applied for optimization of encapsulation systems, are presented and some future developments in the area of nanoencapsulation are discussed.

517 citations

Journal ArticleDOI
TL;DR: Enhanced retinol palmitate uptake should derive from specific SLN effects and is not due to non-specific occlusive properties, as Transepidermal water loss (TEWL) and the influence of drug free SLN on retinyl palmitates uptake exclude pronounced Occlusive effects.

492 citations

Journal Article
TL;DR: In this paper, the authors review types of solid lipid nanoparticles (SLN), principles of drug loading and models of drug incorporation, and the influence of PEG coating on particle size and surface characteristics.
Abstract: Solid lipid nanoparticles (SLN) have been reported to be an alternative system to emulsions, liposomes, microparticles and their polymeric counterparts for various application routes since the early 1990s due to their advantages Various research groups have also increasingly focused on improving their stability in body fluids after administration by coating of particles with hydrophilic molecules such as poly(ethylene)glycol (PEG) derivatives Altering surface characteristics by coating SLN with hydrophilic molecules improves plasma stability and biodistribution, and subsequent bioavailability of drugs entrapped Their storage stability is also increased This paper basicly reviews types of SLN, principles of drug loading and models of drug incorporation The influence of PEG coating on particle size and surface characteristics is discussed followed by alteration in pharmacokinetics and bioavailability of drugs in order to target the site of action via SLN The future direction of research and clinical implications of SLN is also considered

491 citations

Journal ArticleDOI
TL;DR: Improved stability and loading capacities were found for amorphous lipid nanoparticles which present the characteristic signals of supercooled melts in high resolution 1 H-NMR, and significant differences between monoacid triglycerides and complex lipids were found.

481 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023193
2022446
2021242
2020254
2019237
2018226