Topic
Solid lipid nanoparticle
About: Solid lipid nanoparticle is a research topic. Over the lifetime, 3175 publications have been published within this topic receiving 127912 citations. The topic is also known as: LNP & SLN.
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TL;DR: The results indicate that the existence of a Vroman effect, a displacement of previously adsorbed abundant proteins, on USPIO particles has to be denied and leads to the assumption of a long-lived ("hard") protein corona around the iron oxide nanoparticles.
97 citations
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TL;DR: It was concluded that the N LCs enhances the oral bioavailability of the drug and may decrease the side effects and toxicity of the lipids used in other polymeric NPs as NLCs uses physiological and biodegradable lipids.
Abstract: Context: Nanostructured lipid carrier (NLCs) is the second generation solid lipid nanoparticles (NPs) made up of physiological, biocompatible, biodegradable, non-sensitizing and non-irritating lipids.Objective: The main objective of this review is to explore the role of NLCs system for delivering drugs by oral route and thus increasing the oral bioavailability.Methods: The present review article highlights the definition and types of NLCs and their importance as colloidal carriers including the production techniques and their formulation. This review article also deals with the fate of lipids used in the NLCs formulation and the NLCs toxicity.Conclusion: On the basis of the literature survey done, it was concluded that the NLCs enhances the oral bioavailability of the drug and may decrease the side effects and toxicity of the lipids used in other polymeric NPs as NLCs uses physiological and biodegradable lipids.
97 citations
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TL;DR: The cytotoxicity and physical properties of various submicron O/W emulsions and solid lipid nanoparticles for dermal applications were investigated and survival of macrophages was highly affected by stearic acid and stearylamine.
97 citations
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TL;DR: Microwave heating helps to overcome several disadvantages associated with thermal heating and results in improved particle characteristics and there is thus the potential for new opportunities in the development of colloidal carriers.
97 citations
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TL;DR: The contribution of mono-, di- and trivalent ions to the destabilization of solid lipid nanoparticle (SLN) dispersions was investigated, i.e. particle growth and subsequent formation of semi-solid gels.
Abstract: The contribution of mono-, di- and trivalent ions to the destabilization of solid lipid nanoparticle (SLN TM) dispersions was investigated, i.e. particle growth and subsequent formation of semi-solid gels. Sodium, calcium and aluminium chloride were added in varying concentrations to a Compritol formulation which had proved to be highly sensitive towards destabilizing effects. Dispersions containing up to 10-3 m sodium chloride remained stable for 14 days. The same concentrations of calcium or aluminium induced slight and rapid particle growth, respectively. Generally, apronounced destabilizing effect was observed with increasing electrolyte concentration and increasing valence. Higher concentrations of electrolyte (10-2,10-1 m) induced gelation of the systems. The extent of solidification was highly dependent on the crystallinity of the lipid phase. The recrystalization indices of the gels were distinctly higher compared to the liquid systems. Additionally, unstable modifications, being present in liquid...
97 citations