Topic
Solid lipid nanoparticle
About: Solid lipid nanoparticle is a research topic. Over the lifetime, 3175 publications have been published within this topic receiving 127912 citations. The topic is also known as: LNP & SLN.
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TL;DR: The findings suggest that lipid nanoparticles are promising viable carriers for the delivery of resveratrol and VE to provide long‐lasting antioxidant benefits to the skin.
92 citations
Journal Article•
TL;DR: In this paper, a simple device to form solid lipid nanoparticles from warm O/W microemulsions was developed, where precise control of temperature, drop dimensions and delivery rate of the microemulsion was achieved, obtaining reproducible nanoparticle dispersions.
92 citations
TL;DR: A novel use of near-infrared (NIR) aza-BODIPY dyes capable of fluorescence quenching in water to visualize the in vivo fate of model lipid-based nanocarriers, solid lipid nanoparticles (SLNs) showed positive finding, which means that this approach may be useful for in-vivo monitoring of lipid- based nanoccarriers.
92 citations
TL;DR: Since LN are based on lipids that appear in human sebum which is the predominant medium in HF an increased localization of the colloidal carriers as well as a promoted drug release may be assumed, sebum-like lipid material and a size of less or equal 640 nm are appropriate specifications for FP of particulate formulations.
92 citations
TL;DR: It is suggested that LDL‐mimetic SLNs can be utilized as a multifunctional and optically traceable nanocarrier for efficient anticancer theranostics and show synergistic therapeutic effects of paclitaxel‐siRNA combination.
Abstract: Here, we report quantum dot-incorporating solid lipid nanoparticles (SLNs) for anticancer theranostics with synergistic therapeutic effects of paclitaxel-siRNA combination. The natural components of a low-density lipoprotein (LDL) are reconstituted to produce LDL-mimetic SLNs having a stable core/shell nanostructure incorporating quantum dots and paclitaxel within the lipid shell while anionic siRNA molecules are electrostatically complexed with the outer surface of SLNs. The produced SLN/siRNA complexes efficiently deliver both of paclitaxel and Bcl-2 targeted siRNA into human lung carcinoma cells and exhibit synergistic anticancer activities by triggering caspase-mediated apoptosis as determined by median effect plot analysis. Moreover, the strong fluorescence from quantum dots within SLNs enables in situ visualization of intracellular translocation of SLNs into cancer cells. Our study suggests that LDL-mimetic SLNs can be utilized as a multifunctional and optically traceable nanocarrier for efficient anticancer theranostics.
92 citations