scispace - formally typeset
Search or ask a question
Topic

Solid lipid nanoparticle

About: Solid lipid nanoparticle is a research topic. Over the lifetime, 3175 publications have been published within this topic receiving 127912 citations. The topic is also known as: LNP & SLN.


Papers
More filters
Journal ArticleDOI
TL;DR: This review describes the methods currently used to prepare SLNs and NLCs with focus on solvent injection method, and summarizes recent development in SLNs or nanostructured lipid carriers production using this technique.
Abstract: Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) have emerged as potential drug delivery systems for various applications that are produced from physiological, biodegradable, and biocompatible lipids. The methods used to produce SLNs and NLCs have been well investigated and reviewed, but solvent injection method provides an alternative means of preparing these drug carriers. The advantages of solvent injection method include a fast production process, easiness of handling, and applicability in many laboratories without requirement of complicated instruments. The effects of formulations and process parameters of this method on the characteristics of the produced SLNs and NLCs have been investigated in several studies. This review describes the methods currently used to prepare SLNs and NLCs with focus on solvent injection method. We summarize recent development in SLNs and NLCs production using this technique. In addition, the effects of solvent injection process parameters on SLNs and NLCs characteristics are discussed.

92 citations

Journal ArticleDOI
TL;DR: The in vitro HaCaT cell line study demonstrated that SLNs delayed the abrupt growth of keratinocytes, while in vivo mouse tail model showed thatSLNs gel significantly decreased the epidermal thickness and increased melanocyte count in comparison to commercial Daivobet® ointment.
Abstract: Aim: The primary aim of present work was to develop effective combination drug therapy for topical treatment of psoriasis.Methods: Betamethasone dipropionate and calcipotriol loaded solid lipid nanoparticles (CT-BD-SLNs) were prepared by hot melt high shear homogenization technique, which were then incorporated in Carbopol gel matrix. The anti-psoriatic potential was tested by sequential in vitro (skin permeation and dermal distribution, anti-proliferative effect in HaCaT cells) and in vivo (Draize patch irritation, transepidermal water loss (TEWL) and anti-psoriatic mouse tail studies) experiments.Results: A negligible amount in receptor compartment, yet confined distribution of drugs to epidermal and dermal region of skin was observed in case of SLNs, which is essential for safe and effective anti-psoriatic therapy. Draize patch test and TEWL demonstrated negligible skin irritation and better skin tolerability of SLNs. The in vitro HaCaT cell line study demonstrated that SLNs delayed the abrupt growth o...

92 citations

Journal ArticleDOI
TL;DR: Results of present study indicate that SLNs are suitable carriers for entrapment of poorly water soluble drugs and for enhancement of therapeutic efficacy of antifungal drug.

92 citations

Journal ArticleDOI
TL;DR: Nanotechnology opens a door for developing phytochemical-loaded nanoparticles for prevention and treatment of cancer.

91 citations

Journal ArticleDOI
TL;DR: Hy-SLN presented a 30% increase in cell uptake and a correlated improvement of 26% in cytotoxicity, and all these advantages suggest that Hy-loaded SLN has potential for use in photodynamic therapy (PDT).
Abstract: The hydrophobicity of some photosensitizers can induce aggregation in biological systems, which consequently reduces photodynamic activity. The conjugation of photosensitizers with nanocarrier systems can potentially be used to overcome this problem. The objective of this study was to prepare and characterise hypericin-loaded solid lipid nanoparticles (Hy-SLN) for use in photodynamic therapy (PDT). SLN were prepared using the ultrasonication technique, and their physicochemical properties were characterised. The mean particle size was found to be 153 nm, with a low polydispersity index of 0.28. One of the major advantages of the SLN formulation is its high entrapment efficiency (EE%). Hy-SLN showed greater than 80% EE and a drug loading capacity of 5.22% (w/w). To determine the photodynamic efficiency of Hy before and after encapsulation in SLN, the rate constants for the photodecomposition of two (1)O2 trapping reagents, DPBF and AU, were determined. These rate constants exhibited an increase of 60% and 50% for each method, respectively, which is most likely due to an increase in the lifetime of the triplet state caused by the increase in solubility. Hy-SLN presented a 30% increase in cell uptake and a correlated improvement of 26% in cytotoxicity. Thus, all these advantages suggest that Hy-loaded SLN has potential for use in PDT.

91 citations


Network Information
Related Topics (5)
Drug carrier
18.2K papers, 997.7K citations
90% related
Drug delivery
49.7K papers, 1.8M citations
90% related
Micelle
35.1K papers, 1M citations
79% related
Self-healing hydrogels
34.9K papers, 1.2M citations
77% related
Nanoparticle
85.9K papers, 2.6M citations
76% related
Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023193
2022446
2021242
2020254
2019237
2018226