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Solid lipid nanoparticle

About: Solid lipid nanoparticle is a research topic. Over the lifetime, 3175 publications have been published within this topic receiving 127912 citations. The topic is also known as: LNP & SLN.


Papers
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Journal ArticleDOI
TL;DR: Chitosan coated solid lipid nanoparticles (NC)-based nanodelivery systems were developed in order to enhance the stability and oral bioavailability of curcumin and help incorporate it in functional foods and nutraceuticals.

90 citations

Journal ArticleDOI
TL;DR: The evaluation of the in vivo antitumor efficacy of the hierarchically targetable SLN therapy system by oral administration showed the effective inhibition of primary colon tumors and peritoneal metastasis in terms of the ascites volume and tumor nodule number and size, along with the absence of systemic side effects.

90 citations

Journal ArticleDOI
TL;DR: The results indicate that SLNs might be good potential sustained-release delivery vehicles for camptothecin or other lipophilic drugs.
Abstract: Camptothecin (CA), an antitumor drug, was incorporated into solid lipid nanoparticles (SLNs) prepared by high-pressure homogenization. A Taguchi orthogonal experimental design was used to study the influence of four different variables, with each variable having three value levels on nanoparticle size. Analysis of variance (ANOVA) has been used to evaluate the preparation of CA-SLNs and perform product optimization. The optimized CA-SLNs suspension was lyophilized using mannitol and glucose as cryoprotectants. The physicochemical characteristics of CA-SLNs were evaluated using transmission electron microscopy (TEM), electrophoresis, and differential scanning calorimetry (DSC). The release of camptothecin from CA-SLNs in various media was evaluated using a high-performance liquid chromatography (HPLC) method. The results showed that the concentration of emulsifier and the homogenization pressure had a significant influence on the particle size. The optimized CA-SLNs had an average diameter of about...

90 citations

Journal ArticleDOI
01 Dec 2019-Small
TL;DR: P pH-sensitive and peptide-modified liposomes and solid lipid nanoparticles designed for encapsulation of irinotecan and miR-200 exhibit positive therapeutic outcomes by inhibiting colorectal tumor growth and reducing systemic toxicity.
Abstract: Irinotecan is one of the main chemotherapeutic agents for colorectal cancer (CRC). MicroRNA-200 (miR-200) has been reported to inhibit metastasis in cancer cells. Herein, pH-sensitive and peptide-modified liposomes and solid lipid nanoparticles (SLN) are designed for encapsulation of irinotecan and miR-200, respectively. These peptides include one cell-penetrating peptide, one ligand targeted to tumor neovasculature undergoing angiogenesis, and one mitochondria-targeting peptide. The peptide-modified nanoparticles are further coated with a pH-sensitive PEG-lipid derivative with an imine bond. These specially-designed nanoparticles exhibit pH-responsive release, internalization, and intracellular distribution in acidic pH of colon cancer HCT116 cells. These nanoparticles display low toxicity to blood and noncancerous intestinal cells. Delivery of miR-200 by SLN further increases the cytotoxicity of irinotecan-loaded liposomes against CRC cells by triggering apoptosis and suppressing RAS/β-catenin/ZEB/multiple drug resistance (MDR) pathways. Using CRC-bearing mice, the in vivo results further indicate that irinotecan and miR-200 in pH-responsive targeting nanoparticles exhibit positive therapeutic outcomes by inhibiting colorectal tumor growth and reducing systemic toxicity. Overall, successful delivery of miR and chemotherapy by multifunctional nanoparticles may modulate β-catenin/MDR/apoptosis/metastasis signaling pathways and induce programmed cancer cell death. Thus, these pH-responsive targeting nanoparticles may provide a potential regimen for effective treatment of colorectal cancer.

90 citations

Journal ArticleDOI
TL;DR: It was showed that lipid concentration and temperature seemed to be the crucial parameters for the particle size of the monostearin SLN prepared by the solvent diffusion method, however, neither of these factors had a significant quadratic relationship with the zeta potential.

90 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023193
2022446
2021242
2020254
2019237
2018226