Showing papers on "Somatosensory system published in 2010"
TL;DR: Using a new form of optical imaging in a brain slice preparation, it is found that the corticothalamocortical pathway drove robust activity in higher-order somatosensory cortex, suggesting a physiologically viable candidate for information transfer to higher- order cortical areas.
Abstract: An unresolved question in neuroscience relates to the extent to which corticothalamocortical circuits emanating from layer 5B are involved in information transfer through the cortical hierarchy. Using a new form of optical imaging in a brain slice preparation, we found that the corticothalamocortical pathway drove robust activity in higher-order somatosensory cortex. When the direct corticocortical pathway was interrupted, secondary somatosensory cortex showed robust activity in response to stimulation of the barrel field in primary somatosensory cortex (S1BF), which was eliminated after subsequently cutting the somatosensory thalamus, suggesting a highly efficacious corticothalamocortical circuit. Furthermore, after chemically inhibiting the thalamus, activation in secondary somatosensory cortex was eliminated, with a subsequent return after washout. Finally, stimulation of layer 5B in S1BF, and not layer 6, drove corticothalamocortical activation. These findings suggest that the corticothalamocortical circuit is a physiologically viable candidate for information transfer to higher-order cortical areas.
299 citations
TL;DR: It is demonstrated that certain distinctive populations of inhibitory and excitatory interneuron can be recognised in lamina II, and combined with identification of other neurochemical markers should allow further clarification of neuronal circuitry in the superficial dorsal horn.
Abstract: Lamina II contains a large number of interneurons involved in modulation and transmission of somatosensory (including nociceptive) information. However, its neuronal circuitry is poorly understood due to the difficulty of identifying functional populations of interneurons. This information is important for understanding nociceptive processing and for identifying changes that underlie chronic pain. In this study, we compared morphology, neurotransmitter content, electrophysiological and pharmacological properties for 61 lamina II neurons recorded in slices from adult rat spinal cord. Morphology was related to transmitter content, since islet cells were GABAergic, while radial and most vertical cells were glutamatergic. However, there was considerable diversity among the remaining cells, some of which could not be classified morphologically. Transmitter phenotype was related to firing pattern, since most (18/22) excitatory cells, but few (2/23) inhibitory cells had delayed, gap or reluctant patterns, which are associated with A-type potassium (IA) currents. Somatostatin was identified in axons of 14/24 excitatory neurons. These had variable morphology, but most of those tested showed delayed-firing. Excitatory interneurons are therefore likely to contribute to pain states associated with synaptic plasticity involving IA currents. Although noradrenaline and serotonin evoked outward currents in both inhibitory and excitatory cells, somatostatin produced these currents only in inhibitory neurons, suggesting that its pro-nociceptive effects are mediated by disinhibition. Our results demonstrate that certain distinctive populations of inhibitory and excitatory interneuron can be recognised in lamina II. Combining this approach with identification of other neurochemical markers should allow further clarification of neuronal circuitry in the superficial dorsal horn.
286 citations
TL;DR: It is found that even after periods of training as brief as 10 min, sensed limb position was altered and the perceptual change persisted for 24 h, and this change was dependent upon motor learning.
Abstract: Motor learning is dependent upon plasticity in motor areas of the brain, but does it occur in isolation, or does it also result in changes to sensory systems? We examined changes to somatosensory function that occur in conjunction with motor learning. We found that even after periods of training as brief as 10 min, sensed limb position was altered and the perceptual change persisted for 24 h. The perceptual change was reflected in subsequent movements; limb movements following learning deviated from the prelearning trajectory by an amount that was not different in magnitude and in the same direction as the perceptual shift. Crucially, the perceptual change was dependent upon motor learning. When the limb was displaced passively such that subjects experienced similar kinematics but without learning, no sensory change was observed. The findings indicate that motor learning affects not only motor areas of the brain but changes sensory function as well.
257 citations
TL;DR: Findings provide further evidence that fc-fMRI reflects intrinsic brain properties, while also demonstrating that 0.5 MAC sevoflurane anesthesia preferentially modulates higher-order connections.
201 citations
TL;DR: This work has revealed that early molecular regionalization and positional patterning of trigeminal ganglion and brainstem target neurons are established by homeodomain transcription factors, the expression of which is induced and maintained by signals from the brain and face.
Abstract: The facial somatosensory map in the cortex is derived from facial representations that are first established at the brainstem level and then serially 'copied' at each stage of the somatosensory pathway. Recent studies have provided insights into the molecular mechanisms involved in the development of somatotopic maps of the face and whiskers in the trigeminal nuclei of the mouse brainstem. This work has revealed that early molecular regionalization and positional patterning of trigeminal ganglion and brainstem target neurons are established by homeodomain transcription factors, the expression of which is induced and maintained by signals from the brain and face. Such position-dependent information is fundamental in transforming the early spatial layout of sensory receptors into a topographic connectivity map that is conferred to higher brain levels.
193 citations
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TL;DR: An analytic model of how tactile information interacts with mental body representations in the brain is presented and four interactions are described: the link between the body surface and the maps in primary somatosensory cortex, the contribution of somatoensory cortical information to mental body representation, the feedback pathway from such higher representations back to primary tactile processing in somatosensor cortex, and the modulation of tactile object perception bymental body representations.
184 citations
TL;DR: The substantial potential TC innervation of all excitatory neuron types in a cortical column constitutes an anatomical basis for the initial near-simultaneous representation of a sensory stimulus in different neuron types.
Abstract: This is the concluding article in a series of 3 studies that investigate the anatomical determinants of thalamocortical (TC) input to excitatory neurons in a cortical column of rat primary somatosensory cortex (S1). We used viral synaptophysin-enhanced green fluorescent protein expression in thalamic neurons and reconstructions of biocytin-labeled cortical neurons in TC slices to quantify the number and distribution of boutons from the ventral posterior medial (VPM) and posteromedial (POm) nuclei potentially innervating dendritic arbors of excitatory neurons located in layers (L)2-6 of a cortical column in rat somatosensory cortex. We found that 1) all types of excitatory neurons potentially receive substantial TC input (90-580 boutons per neuron); 2) pyramidal neurons in L3-L6 receive dual TC input from both VPM and POm that is potentially of equal magnitude for thick-tufted L5 pyramidal neurons (ca. 300 boutons each from VPM and POm); 3) L3, L4, and L5 pyramidal neurons have multiple (2-4) subcellular TC innervation domains that match the dendritic compartments of pyramidal cells; and 4) a subtype of thick-tufted L5 pyramidal neurons has an additional VPM innervation domain in L4. The multiple subcellular TC innervation domains of L5 pyramidal neurons may partly explain their specific action potential patterns observed in vivo. We conclude that the substantial potential TC innervation of all excitatory neuron types in a cortical column constitutes an anatomical basis for the initial near-simultaneous representation of a sensory stimulus in different neuron types.
181 citations
TL;DR: It is suggested that the brain could use self representation as a reference for perception of others' body parts in parietal cortex and bimodal neurons may contribute to spatial matching between the bodies of the self and others in both action recognition and imitation.
Abstract: Parietal cortex contributes to body representations by integrating visual and somatosensory inputs. Because mirror neurons in ventral premotor and parietal cortices represent visual images of others' actions on the intrinsic motor representation of the self, this matching system may play important roles in recognizing actions performed by others. However, where and how the brain represents others' bodies and correlates self and other body representations remain unclear. We expected that a population of visuotactile neurons in simian parietal cortex would represent not only own but others' body parts. We first searched for parietal visuotactile bimodal neurons in the ventral intraparietal area and area 7b of monkeys, and then examined the activity of these neurons while monkeys were observing visual or tactile stimuli placed on the experimenter's body parts. Some bimodal neurons with receptive fields (RFs) anchored on the monkey's body exhibited visual responses matched to corresponding body parts of the experimenter, and visual RFs near that body part existed in the peripersonal space within approximately 30 cm from the body surface. These findings suggest that the brain could use self representation as a reference for perception of others' body parts in parietal cortex. These neurons may contribute to spatial matching between the bodies of the self and others in both action recognition and imitation.
164 citations
TL;DR: The results of magnetoencephalography used to investigate whether expectation of a tactile event involves a pre-stimulus modulation of neuronal oscillations in human somatosensory cortex show that perception is an active process that starts even prior to sensation.
146 citations
TL;DR: It is shown that a complete thoracic transection of the spinal cord produces immediate functional reorganization in the primary somatosensory cortex of anesthetized rats, and that this state change plays a critical role in the early cortical reorganization after spinal cord injury.
Abstract: Spinal cord injury can produce extensive long-term reorganization of the cerebral cortex. Little is known, however, about the sequence of cortical events starting immediately after the lesion. Here we show that a complete thoracic transection of the spinal cord produces immediate functional reorganization in the primary somatosensory cortex of anesthetized rats. Besides the obvious loss of cortical responses to hindpaw stimuli (below the level of the lesion), cortical responses evoked by forepaw stimuli (above the level of the lesion) markedly increase. Importantly, these increased responses correlate with a slower and overall more silent cortical spontaneous activity, representing a switch to a network state of slow-wave activity similar to that observed during slow-wave sleep. The same immediate cortical changes are observed after reversible pharmacological block of spinal cord conduction, but not after sham. We conclude that the deafferentation due to spinal cord injury can immediately (within minutes) change the state of large cortical networks, and that this state change plays a critical role in the early cortical reorganization after spinal cord injury.
132 citations
TL;DR: Electrophysiology-delivery of fluorescent viral vectors-and two-photon microscopy were used to demonstrate the rapidity of axonal restructuring of both excitatory and inhibitory neurons in rodent cortical layer II/III following alterations in sensory experience.
Abstract: Cortical topography can be remapped as a consequence of sensory deprivation, suggesting that cortical circuits are continually modified by experience. To see the effect of altered sensory experience on specific components of cortical circuits, we imaged neurons, labeled with a genetically modified adeno-associated virus, in the intact mouse somatosensory cortex before and after whisker plucking. Following whisker plucking we observed massive and rapid reorganization of the axons of both excitatory and inhibitory neurons, accompanied by a transient increase in bouton density. For horizontally projecting axons of excitatory neurons there was a net increase in axonal projections from the non-deprived whisker barrel columns into the deprived barrel columns. The axon collaterals of inhibitory neurons located in the deprived whisker barrel columns retracted in the vicinity of their somata and sprouted long-range projections beyond their normal reach towards the non-deprived whisker barrel columns. These results suggest that alterations in the balance of excitation and inhibition in deprived and non-deprived barrel columns underlie the topographic remapping associated with sensory deprivation.
TL;DR: The prestimulus causal influence in the mu band from prefrontal cortex to SI was significantly higher for perceived stimulus than for unperceived stimulus, indicating that frontal executive structures, via ongoing mu oscillations, exert cognitive control over posterior sensory cortices to facilitate somatosensory processing.
Abstract: The ongoing neural activity in human primary somatosensory cortex (SI) is characterized by field potential oscillations in the 7-13 Hz range known as the mu rhythm. Recent work has shown that the magnitude of the mu oscillation immediately preceding the onset of a weak stimulus has a significant impact on its detection. The neural mechanisms mediating this impact remain not well understood. In particular, whether and how somatosensory mu rhythm is modulated by executive areas prior to stimulus onset for improved behavioral performance has not been investigated. We addressed these issues by recording 128-channel scalp electroencephalogram from normal volunteers performing a somatosensory perception experiment in which they reported the detection of a near-threshold electrical stimulus (â¼50% detection rate) delivered to the right index finger. Three results were found. First, consistent with numerous previous reports, the N1 component (â¼140 msec) of the somatosensory-evoked potential was significantly enhanced for perceived stimulus compared to unperceived stimulus. Second, the prestimulus mu power and the evoked N1 amplitude exhibited an inverted-U relationship, suggesting that an intermediate level of prestimulus mu oscillatory activity is conducive to stimulus processing and perception. Third, a Granger causality analysis revealed that the prestimulus causal influence in the mu band from prefrontal cortex to SI was significantly higher for perceived stimulus than for unperceived stimulus, indicating that frontal executive structures, via ongoing mu oscillations, exert cognitive control over posterior sensory cortices to facilitate somatosensory processing.
01 Jan 2010
TL;DR: An early developmental critical period for plasticity and structural changes in principal neurons of the olfactory cortex in response to sensory afferent activity is demonstrated and an optogenetic approach is used to reveal that cortical feedback projections provide inhibition onto mitral cells in the Olfactory bulb via activation of granule cells.
Abstract: Author(s): Poo, Cindy | Abstract: Events in our external world are transformed into internal percepts and experiences. How can we begin to understand this transformation? It starts with the stimulation of peripheral sensory organs and ultimately requires the holistic synthesis of ensemble neural activity in the cortex. The cortex is composed of circuits connecting diverse types of neurons across various functional brain regions. In order to fully understand the cortical representation of an external stimulus, we must dissect out basic components of the circuit and characterize their stimulus response properties. We study neural circuits in primary olfactory (piriform) cortex of rodents using electrophysiological recordings in brain slices and l italicgin vivo. We examine the underlying synaptic mechanisms of odor representations, and how it can be modulated. First, we demonstrate an early developmental critical period for plasticity and structural changes in principal neurons of the olfactory cortex in response to sensory afferent activity. Next, we use in vivo recordings to demonstrate that synaptic inhibition is widely recruited by odor stimuli, whereas synaptic excitation is more selective in principal neurons. We show that the recruitment of both local interneurons as well as intracortical excitatory connections serve to shape odor-evoked synaptic activity. Synchronous beta (15-30 Hz) oscillations between the olfactory cortex and bulb are thought to be important for odor discrimination. We find that odor-evoked synaptic currents in principle cells of olfactory cortex are couple to beta frequency oscillations in the local field potential. A time window between oscillatory synaptic excitation and inhibition restricts the spike timing of odor-evoked spikes. Beta frequency oscillations have been shown to require a centrifugal feedback loop from olfactory cortex back to the bulb. We use an optogenetic approach to reveal that cortical feedback projections provide inhibition onto mitral cells in the olfactory bulb via activation of granule cells. This work establishes a framework to understand basic components of odor representations in olfactory cortex, and a role for cortico-bulbar feedback loop. In combination with work done in the visual, auditory, somatosensory and gustatory cortices, this study contributes to a more complete understanding of sensory information processing by cortical circuits
TL;DR: The results suggest that the top-down modulation ofThalamic neurons from cortical layer 6 involves an inhibitory component via the thalamic reticular nucleus, and this component can be selectively reduced by cholinergic input.
Abstract: The pathway from cortical layer 6 to the thalamus is a property of all thalamic relay nuclei. This pathway, as a population, directly excites relay cells and indirectly inhibits them via the thalamic reticular nucleus. To understand the circuit organization of this cortical feedback, we used laser-scanning photostimulation, which specifically activates somata or dendrites, to stimulate the primary somatosensory cortex in an in vitro thalamocortical slice preparation while recording from neurons of the ventral posterior medial nucleus. Layer 6 photostimulation evoked biphasic excitatory postsynaptic current/inhibitory postsynaptic current (EPSC/IPSC) responses in the neurons of the ventral posterior medial nucleus, indicating that such photostimulation strongly activates reticular cells. These disynaptic IPSCs were greatly suppressed or abolished by bath application of the muscarinic agonist acetyl-b-methylcholine. Our results suggest that the top-down modulation of thalamic neurons from cortical layer 6 involves an inhibitory component via the thalamic reticular nucleus, and this component can be selectively reduced by cholinergic input. Finally, we found the footprints for the excitatory corticothalamic and the inhibitory corticoreticulo-thalamic inputs to be located in similar positions, though in some cases they are offset. Both patterns have implications for cortico-reticulo-thalamic circuitry.
TL;DR: The data suggest that “top-down” influences from lateralized areas within Ins and S1 selectively affect interoceptive over exteroceptive nociceptive inputs onto Sp5C, which could contribute to the development of migraine pain in terms of both topographic localization and pain tuning during an attack.
Abstract: Alterations in cortical excitability are implicated in the pathophysiology of migraine. However, the relationship between cortical spreading depression (CSD) and headache has not been fully elucidated. We aimed to identify the corticofugal networks that directly influence meningeal nociception in the brainstem trigeminocervical complex (Sp5C) of the rat. Cortical areas projecting to the brainstem were first identified by retrograde tracing from Sp5C areas that receive direct meningeal inputs. Anterograde tracers were then injected into these cortical areas to determine the precise pattern of descending axonal terminal fields in the Sp5C. Descending cortical projections to brainstem areas innervated by the ophthalmic branch of the trigeminal nerve originate contralaterally from insular (Ins) and primary somatosensory (S1) cortices and terminate in laminae I-II and III-V of the Sp5C, respectively. In another set of experiments, electrophysiological recordings were simultaneously performed in Ins, S1 or primary visual cortex (V1), and Sp5C neurons. KCl was microinjected into such cortical areas to test the effects of CSD on meningeal nociception. CSD initiated in Ins and S1 induced facilitation and inhibition of meningeal-evoked responses, respectively. CSD triggered in V1 affects differently Ins and S1 cortices, enhancing or inhibiting meningeal-evoked responses of Sp5C, without affecting cutaneous-evoked nociceptive responses. Our data suggest that "top-down" influences from lateralized areas within Ins and S1 selectively affect interoceptive (meningeal) over exteroceptive (cutaneous) nociceptive inputs onto Sp5C. Such corticofugal influences could contribute to the development of migraine pain in terms of both topographic localization and pain tuning during an attack.
TL;DR: It is suggested that multimodal encoding and perceptual judgments in these tasks occur outside the sensory cortices studied here, and the identity of the stimulus could only be decoded from responses to their principal sensory modality during the stimulation periods and not during the processing steps that link sensation and decision making.
TL;DR: Assessment of somatosensory functions may have implications for future neuromodulatory treatment of pain complaints and motor rehabilitation programs in children and adults with cerebral palsy.
TL;DR: The view that intermingled neurons in primary sensory areas send specific stimulus features to different parts of the brain is supported, including those projecting to primary motor cortex and secondary somatosensory area.
Abstract: Nearby neurons, sharing the same locations within the mouse whisker map, can have dramatically distinct response properties. To understand the significance of this diversity, we studied the relationship between the responses of individual neurons and their projection targets in the mouse barrel cortex. Neurons projecting to primary motor cortex (MI) or secondary somatosensory area (SII) were labeled with red fluorescent protein (RFP) using retrograde viral infection. We used in vivo two-photon Ca(2+) imaging to map the responses of RFP-positive and neighboring L2/3 neurons to whisker deflections. Neurons projecting to MI displayed larger receptive fields compared with other neurons, including those projecting to SII. Our findings support the view that intermingled neurons in primary sensory areas send specific stimulus features to different parts of the brain.
TL;DR: Impairment of these somatosensory percepts suggests a short-term suppression of lemniscal or suprathalamic sensory pathways following motor cortex stimulation by cathodal tDCS.
TL;DR: Stress‐induced analgesia seems to activate similar brain networks as placebo analgesia or analgesia mediated by diffuse noxious inhibitory controls and involved sensory, affective and cognitive modulatory circuits.
Abstract: Stress-induced analgesia (SIA) refers to a reduced pain response after stress exposure, which is mediated by descending pain-inhibitory circuits and may be an indicator of adequate centrally mediated pain control. We used functional magnetic resonance imaging to assess brain mechanisms of SIA in 21 healthy participants. Using a block design series of mildly painful pressure stimuli were applied to the left medial phalanx of the second digit during functional magnetic resonance imaging. Mental arithmetic combined with increasing levels of noise was used as a stressor. Verbal ratings, changes in blood pressure and heart rate confirmed the validity of the stress induction. Post-stress pain thresholds and pain tolerance were significantly higher and post-stress pain and unpleasantness ratings were significantly lower compared to pre-stress levels. SIA led to an increase of the blood-level-dependent oxygenation response in the primary somatosensory cortex, bilaterally in the anterior insula, and secondary somatosensory cortex. The increase in pain tolerance correlated significantly with activation in the rostral anterior cingulate cortex and pain unpleasantness with activation in the dorsal anterior cingulate cortex. SIA seems to activate similar brain networks as placebo analgesia or analgesia mediated by diffuse noxious inhibitory controls and involved sensory, affective and cognitive modulatory circuits.
TL;DR: It is demonstrated that mice, like other vertebrates, have two classes of slowly adapting light-touch receptors, a simple method to distinguish these populations is identified, and the utility of skin-nerve recordings for genetic dissection of touch receptor mechanisms is extended.
Abstract: Touch is initiated by diverse somatosensory afferents that innervate the skin. The ability to manipulate and classify receptor subtypes is prerequisite for elucidating sensory mechanisms. Merkel ce...
TL;DR: Mechanisms of reorganization following pre- and perinatally-acquired, unilateral brain lesions for motor, somatosensory, and language functions are described and taken over by the right hemisphere in cases of left hemispheric damage.
TL;DR: SI dynamically shapes its representation of a tactile stimulus by selecting among all of its neurons initially activated by the stimulus a subset of neurons with receptive-field and feature-tuning properties closely matching those of the stimulus.
TL;DR: The results suggest that when people observe somebody else being touched, activation of their own somatosensory circuitry may contribute to understanding of the other person’s somatoensory experience.
Abstract: We used magnetoencephalography to show that the human primary somatosensory (SI) cortex is activated by mere observation of touch. Somatosensory evoked fields were measured from adult human subjects in two conditions. First, the experimenter touched the subject's right hand with her index finger (Experienced touch). In the second condition, the experimenter touched her own hand in a similar manner (Observed touch). Minimum current estimates were computed across three consecutive 300-ms time windows (0-300, 300-600 and 600-900 ms) with respect to touch onset. During 'Experienced touch', as expected, the contralateral (left) SI cortex was strongly activated in the 0-300 ms time window. In the same time window, statistically significant activity also occurred in the ipsilateral SI, although it was only 2.5% of the strength of the contralateral activation; the ipsilateral activation continued in the 300-600 ms time window. During 'Observed touch', the left SI cortex was activated during the 300-600 ms interval; the activation strength was 7.5% of that during the significantly activated period (0-300 ms) of 'Experienced touch'. The results suggest that when people observe somebody else being touched, activation of their own somatosensory circuitry may contribute to understanding of the other person's somatosensory experience.
TL;DR: In this paper, a review of previous studies on high frequency oscillations (HFOs)>300 Hz overlying the cortical response in the somatosensory evoked potential (SEP) or magnetic field (SEF) in humans as well as other mammals is presented.
TL;DR: The data support that the metaboreflex is mediated by the medulla, whereas the somatosensory, insular, and anterior cingulate cortices are involved in the sensory and affective components of the maneuver.
Abstract: Static isometric exercise increases muscle sympathetic nerve activity (MSNA) and mean arterial pressure, both of which can be maintained at the conclusion of the exercise by occlusion of the arterial supply [postexercise ischemia (PEI)] To identify the cortical and subcortical sites involved, and to differentiate between central command and reflex inputs, we used blood oxygen level-dependent (BOLD) functional MRI (fMRI) of the whole brain (3 T) Subjects performed submaximal static handgrip exercise for 2 min followed by 6 min of PEI; MSNA was recorded on a separate day During the contraction phase, parallel increases in BOLD signal intensity occurred in the contralateral primary motor cortex and cerebellar nuclei and cortex; these matched the effort profile and ceased at the conclusion of the contraction Progressive increases in the contralateral insula and primary and secondary somatosensory cortices, with progressive decreases in the perigenual anterior cingulate and midcingulate cortices, were sustained during the period of PEI and thus did not depend on central command Discrete bilateral activation of the medial and lateral dorsal medulla was also observed during the contraction and PEI; we believe that these represent the nucleus tracts solitarius (NTS) and rostral ventrolateral medulla (RVLM), respectively Given that metaboreceptor afferents are known to project to the NTS and that the RVLM is the primary output nucleus for MSNA, our data support that the metaboreflex is mediated by the medulla, whereas the somatosensory, insular, and anterior cingulate cortices are involved in the sensory and affective components of the maneuver
TL;DR: Dopamine but not subthalamic nucleus deep brain stimulation restores the altered somatosensory temporal discrimination in patients with Parkinson's disease and restores the interplay between cortical and subcortical structures.
Abstract: Whereas numerous studies document the effects of dopamine medication and deep brain stimulation on motor function in patients with Parkinson’s disease, few have investigated deep brain stimulation-induced changes in sensory functions. In this study of 13 patients with Parkinson’s disease, we tested the effects of deep brain stimulation on the somatosensory temporal discrimination threshold. To investigate whether deep brain stimulation and dopaminergic medication induce similar changes in somatosensory discrimination, somatosensory temporal discrimination threshold values were acquired under four experimental conditions: (i) medication ON/deep brain stimulation on; (ii) medication ON/deep brain stimulation off; (iii) medication OFF/deep brain stimulation on; and (iv) medication OFF/deep brain stimulation off. Patients also underwent clinical and neuropsychological evaluations during each experimental session. Somatosensory temporal discrimination threshold values obtained in patients were compared with 13 age-matched healthy subjects. Somatosensory temporal discrimination threshold values were significantly higher in patients than in healthy subjects. In patients, somatosensory temporal discrimination threshold values were significantly lower when patients were studied in medication ON than in medication OFF conditions. Somatosensory temporal discrimination threshold values differed significantly between deep brain stimulation on and deep brain stimulation off conditions only when the patients were studied in the medication ON condition and were higher in the deep brain stimulation on/medication ON than in the deep brain stimulation off/medication ON condition. Dopamine but not subthalamic nucleus deep brain stimulation restores the altered somatosensory temporal discrimination in patients with Parkinson’s disease. Deep brain stimulation degrades somatosensory temporal discrimination by modifying central somatosensory processing whereas dopamine restores the interplay between cortical and subcortical structures.
TL;DR: It is suggested that sleep-related motor activity contributes to the development of neocortical and hippocampal circuits and provides a foundation on which coordinated activity between these two forebrain structures develops.
Abstract: We recently reported that the majority of hippocampal neurons in newborn rats increase their activity in association with myoclonic twitches, which are indicative of active sleep. Because spindle bursts in the developing somatosensory neocortex occur in response to sensory feedback from myoclonic twitching, we hypothesized that the state-dependent activity of the newborn hippocampus arises from sensory feedback that sequentially activates the neocortex and then hippocampus, constituting an early form of neocortical-hippocampal communication. Here, in unanesthetized 5- to 6-d-old rats, we test this hypothesis by recording simultaneously from forelimb and barrel regions of somatosensory neocortex and dorsal hippocampus during periods of spontaneous sleep and wakefulness and in response to peripheral stimulation. Myoclonic twitches were consistently followed by neocortical spindle bursts, which were in turn consistently followed by bursts of hippocampal unit activity; moreover, spindle burst power was positively correlated with hippocampal unit activity. In addition, exogenous stimulation consistently evoked this neocortical-to-hippocampal sequence of activation. Finally, parahippocampal lesions that disrupted functional connections between the neocortex and hippocampus effectively disrupted the transmission of both spontaneous and evoked neocortical activity to the hippocampus. These findings suggest that sleep-related motor activity contributes to the development of neocortical and hippocampal circuits and provides a foundation on which coordinated activity between these two forebrain structures develops.
TL;DR: This study suggests that cervical spine manipulation may alter cortical integration of dual somatosensory input and help to elucidate the mechanisms responsible for the effective relief of pain and restoration of functional ability documented after spinal manipulation treatment.
TL;DR: There are elevations in sensory thresholds with age for multimodal somatosensory and gustatory senses, and males were less sensitive than females for cool at the chin site, for touch, and for sour taste.
Abstract: Declines in sensory functioning with aging are evident for many of the senses. In the present study, thresholds were determined for somatosensory (warming and cooling temperature, pain, touch, and two-point discrimination) and taste stimuli in 178 healthy individuals aged 20-89 yrs. Somatosensory stimuli were applied to the upper lip (glabrous skin) and the chin (hairy skin). The sample was divided into two groups, based on a bimodal split “< 45 yrs” and “≥ 65 yrs”. In all instances, there were elevations in thresholds for the older individuals. Further, males were less sensitive than females for cool at the chin site, for touch, and for sour taste. We conclude that there are elevations in sensory thresholds with age for multimodal somatosensory and gustatory senses.