Topic
Sperm motility
About: Sperm motility is a research topic. Over the lifetime, 13874 publications have been published within this topic receiving 416587 citations. The topic is also known as: sperm movement & GO:0097722.
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TL;DR: The data suggest that avoiding glycerol toxicity either by reducing the concentration used or by adding Glycerol at a lower temperature, or both, may improve human sperm cryosurvival rates.
131 citations
TL;DR: The risk of long‐term infertility from treatment with the PADIC regimen is low and the inclusion of additional drugs such as methotrexate, bleomycin, dactinomycin), or cyclophosphamide did not significantly affect the recovery of spermatogenesis.
Abstract: Because treatment with surgery and combination chemotherapy produces a high cure rate in young men with osteosarcoma, their subsequent reproductive function is an important concern. Semen analyses of osteosarcoma patients, therefore, were performed before, during, and after treatment with the PADIC regimen consisting of cisplatin, Adriamycin (doxorubicin), and dacarbazine or, in some cases, the PADIC regimen plus additional drugs. Results showed that semen volume was not affected and that sperm motility was reduced only during treatment. Although nearly all patients were rendered azoospermic during treatment, sperm production resumed in 30 of 32 patients examined at least 2 years after treatment. Analysis with correction for censored data indicates that, in 78% of treated men, sperm counts will return to more than 10 million/ml. The percentage of men whose sperm counts recovered to normal was lower for those receiving cisplatin dosages greater than or equal to 600 mg/m2; no trends were observed with Adriamycin and dacarbazine dosages. The inclusion of additional drugs such as methotrexate, bleomycin, dactinomycin, or cyclophosphamide (less than 4 g/m2) did not significantly affect the recovery of spermatogenesis. We conclude that the risk of long-term infertility from treatment with the PADIC regimen is low.
131 citations
TL;DR: It is demonstrated that a febrile episode can have marked effects on semen parameters and sperm DNA integrity and is particularly important for the counseling of infertile couples and in relation to assisted reproductive techniques (ART).
131 citations
TL;DR: The studies demonstrated that ODF capacitated sperm and sustained motility, but sperm were capacitated more rapidly in non-luteal than in luteal ODF, suggesting that different mechanisms may operate in ODF and FF to regulate these events.
Abstract: The ability of bovine follicular fluid (FF) and oviduct fluid (ODF) to capacitate sperm was determined. At concentrations of greater than 20%, both FF and ODF capacitated sperm within 4 hours, but at concentrations greater than 40%, FF also initiated the acrosome reaction. Non-luteal ODF at a concentration greater than 60% capacitated sperm within 2 hours. Non-luteal ODF maintained sperm motility better than either luteal ODF or FF. Sperm previously capacitated in ODF underwent the acrosome reaction when exposed to solubilized zonae pellucidae (25 ng/microL) or FF (20%, V/V). Sperm treated with 60% non-luteal ODF or 60% FF fertilized more oocytes at 2 hours than did sperm in treatments with less concentrated fluid. After 4 hours, all fluid treatments and modified Tyrode's medium supplemented with heparin exhibited a higher percentage of fertilized oocytes than the modified Tyrode's medium alone. Concentrations of both protein and glycosaminoglycans were significantly lower in ODF than in either blood serum or FF. These studies demonstrated that ODF capacitated sperm and sustained motility, but sperm were capacitated more rapidly in non-luteal than in luteal ODF. In contrast, FF was able to both capacitate sperm and induce the acrosome reaction. These effects of ODF and FF on aspects of sperm function were uniquely concentration-dependent, suggesting that different mechanisms may operate in ODF and FF to regulate these events.
131 citations
TL;DR: In many cases of chronic epididymitis, the number of leukocytes in the ejaculate is below the threshold of 106 per ml; therefore, consideration of additional markers of inflammation such as granulocyte elastase, pro‐inflammatory cytokines or reactive oxygen species is helpful for establishing the diagnosis.
Abstract: Chronic inflammatory conditions of the genital tract are frequently encountered in male fertility problems. The diagnosis, however, is hampered by a mostly asymptomatic course of the disease as well as inappropriate definitions and unspecific diagnostic criteria. With regard to their impact on male reproductive function, epididymitis seems to be more relevant than inflammation/infection of the prostate and/or seminal vesicles. Chronic epididymitis may result in reduced sperm count and motility. Impaired sperm motility because of epididymal dysfunction is frequently associated with an atypical staining behaviour of sperm tails. In many cases of chronic epididymitis, the number of leukocytes in the ejaculate is below the threshold of 10(6) per ml; therefore, consideration of additional markers of inflammation such as granulocyte elastase, pro-inflammatory cytokines (e.g. interleukin-6 or 8) or reactive oxygen species is helpful for establishing the diagnosis. Besides changes in the conventional sperm parameters, alterations in DNA integrity have been observed. Positive effects of antiphlogistic/antibiotic treatment on semen quality have been reported; however, controlled prospective studies are still lacking.
131 citations