Topic
Sperm motility
About: Sperm motility is a research topic. Over the lifetime, 13874 publications have been published within this topic receiving 416587 citations. The topic is also known as: sperm movement & GO:0097722.
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TL;DR: Based on a controlled study of efficacy, L-carnitine therapy was effective in increasing semen quality, especially in groups with lower baseline levels, however, these results need to be confirmed by larger clinical trials and in vitro studies.
237 citations
TL;DR: It is proposed that the deleterious effects of VCZ on the male reproductive system are mediated by imprinting defects in the sperm, and, surprisingly, VCZ altered the methylation of Peg3.
Abstract: Endocrine-disrupting chemicals (EDCs), among which is the antiandrogen vinclozolin (VCZ), have been reported to affect the male reproductive system. In this study, VCZ was administered to pregnant mice at the time of embryo sex determination, and its possible effects on the differentially methylated domains (DMDs) of two paternally (H19 and Gtl2) and three maternally (Peg1, Snrpn, and Peg3) imprinted genes were tested in the male offspring. The CpGs methylation status within the five gene DMDs was analyzed in the sperm, tail, liver, and skeletal muscle DNAs by pyrosequencing. In the sperm of controls, the percentages of methylated CpGs were close to the theoretical values of 100 and 0% in paternally or maternally imprinted genes respectively. VCZ decreased the percentages of methylated CpGs of H19 and Gtl2 (respective values 83.1 and 91.5%) and increased those of Peg1, Snrpn, and Peg3 (respective values 11.3, 18.3, and 11.2%). The effects of VCZ were transgenerational, but they disappeared gradually from F1 to F3. The mean sperm concentration of the VCZ-administered female offspring was only 56% of that of the controls in the F1 offspring, and it was back to normal values in the F2 and F3 offspring. In the somatic cells of controls, the percentages of methylated CpGs were close to the theoretical value of 50% and, surprisingly, VCZ altered the methylation of Peg3. We propose that the deleterious effects of VCZ on the male reproductive system are mediated by imprinting defects in the sperm. The reported effects of EDCs on human male spermatogenesis might be mediated by analogous imprinting alterations.
237 citations
TL;DR: The data suggest that EMR emitted by cellular phone influences human sperm motility and long-term EMR exposure may lead to behavioral or structural changes of the male germ cell.
237 citations
TL;DR: Gonadotropin-induced testicular production of 17 alpha, 20 beta-dihydroxy-4-pregnen-3-one, the oocyte maturation-inducing hormone of salmonid fish, is responsible for the acquisition of sperm motility but neither testosterone (T) nor 11-ketotestosterone (11-KT), the two major androgens in teleost fish, were effective.
Abstract: In salmonid fish, spermatozoa taken from the testes are immotile, but acquire motility during their passage through the sperm duct. Using male masu salmon (Oncorhynchus masou), we found that gonadotropin-induced testicular production of 17 alpha, 20 beta-dihydroxy-4-pregnen-3-one (17 alpha, 20 beta-DP), the oocyte maturation-inducing hormone of salmonid fish, is responsible for the acquisition of sperm motility. However, neither testosterone (T) nor 11-ketotestosterone (11-KT), the two major androgens in teleost fish, were effective. We also present evidence that 17 alpha, 20 beta-DP action is mediated through an increase in sperm duct pH, which in turn increases the cAMP content of sperm allowing the acquisition of motility.
237 citations
TL;DR: Surprisingly, cyclic AMP analogues almost completely rescued the motility and infertility phenotypes of NHE-null males, and provides an attractive contraceptive target, given its cell-specific expression and absolute requirement for fertility.
Abstract: It has long been speculated that intracellular pH is a critical regulator of both invertebrate and vertebrate sperm motility1,2,3, and sodium–hydrogen exchange has been suggested as a mediator of such pHi regulation in various instances4,5 Two sodium–hydrogen exchangers (NHE1 and NHE5) are expressed in spermatozoa6 However, elimination of the NHE1 gene fails to cause infertility7, suggesting that normal sperm function is maintained in NHE1-null animals Here, we used a functionally unbiased signal peptide trap screen to identify a novel sperm-specific NHE The NHE contains 14 predicted transmembrane segments, including a potential voltage sensor and a consensus cyclic nucleotide-binding motif Testis histology, sperm numbers and morphology were normal, but NHE-null males were completely infertile with severely diminished sperm motility The addition of ammonium chloride, which elevates intracellular pH, partially rescued the motility and fertility defects Surprisingly, cyclic AMP analogues almost completely rescued the motility and infertility phenotypes The existence of this new sperm NHE provides an attractive contraceptive target, given its cell-specific expression and absolute requirement for fertility
236 citations