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Sperm motility

About: Sperm motility is a research topic. Over the lifetime, 13874 publications have been published within this topic receiving 416587 citations. The topic is also known as: sperm movement & GO:0097722.


Papers
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Journal ArticleDOI
TL;DR: The finding that fewer spermatozoa in Portion I of the ejaculate showed early apoptosis post-freezing, suggests boar spermatozosa in this portion of the seminal plasma are less sensitive to the stress induced by cryopreservation.

218 citations

Journal ArticleDOI
TL;DR: It is demonstrated that human sperm express the CB(1), but not CB(2), cannabinoid receptor (CB-R) subtype located in the head and middle piece of the sperm, which negatively influences important sperm functions and suggests a possible role for the cannabinoid system in the pathogenesis of some forms of male infertility.
Abstract: Cannabinoids and endocannabinoids negatively influence sperm functions. These substances have been demonstrated in many mammalian tissues, including male and female reproductive tracts, and previous studies have shown the presence of functional receptors for cannabinoids in human sperm. The present study, by means of RT-PCR and Western blot techniques, demonstrates that human sperm express the CB(1), but not CB(2), cannabinoid receptor (CB-R) subtype located in the head and middle piece of the sperm. The activation of this receptor by anandamide reduces sperm motility and inhibits capacitation-induced acrosome reaction. Activation of the CB(1)-R did not induce any variation in sperm intracellular calcium concentrations, but produced a rapid plasma membrane hyperpolarization that was reduced by the K(+) channel blocker tetraethylammonium. The effects of anandamide on human sperm motility were dependent on the reduction of sperm mitochondrial activity as determined by rhodamine 123 fluorescence. The specificity of anandamide effects in human sperm were confirmed by the effects of the CB(1)-R antagonist SR141716. These findings provide additional evidence that human sperm express functional CB(1)-R, the activation of which negatively influences important sperm functions, and suggest a possible role for the cannabinoid system in the pathogenesis of some forms of male infertility.

218 citations

Journal ArticleDOI
TL;DR: In this article, a two-step continuous Percoll gradient was used to separate motile sperm and a one-step discontinuous Percoll gradients was used for motility enhancement.

217 citations

Journal ArticleDOI
TL;DR: It is suggested that consistent with quality standards that should be required for cryoprotectant media and because of the superior quality of the egg yolk-free extender, a defined soybean lecithin-containing diluter might be the better choice as a semen extender in the future.

217 citations

Journal ArticleDOI
TL;DR: Clinicians should stimulate clinicians to place more emphasis on the prevention of infection-related infertility than on its treatment, as the latter is often unsuccessful.
Abstract: There are several mechanisms acting in synergism that can impair sperm characteristics of patients with accessory gland infection In some cases, conventional sperm variables are disturbed with oligo and/or asthenozoospermia In other patients, these sperm variables may appear normal, but the functional capacity of spermatozoa may be impaired In particular, changes in the composition of the sperm membrane may result in reduced acrosome reactivity and capacity to fuse with the oolemma, and oxidative damage of the sperm DNA may induce mutagenesis Changes in the biochemical make-up of seminal plasma can also reduce the in-vivo fertilizing capacity of spermatozoa, and infection-related disruption of the blood-testis barrier can induce the generation of anti-sperm antibodies and immunological infertility Many of these functional abnormalities will not become evident upon 'basic semen analysis', which explains why some authors are unable to link infection of the accessory sex glands to subfertility Also, functional and anatomical damage acquired as a result of infection is often permanent and not reversible by (antibiotic) treatment Clearly, there are many more aspects of male accessory gland infection that require investigation Available data should stimulate clinicians to place more emphasis on the prevention of infection-related infertility than on its treatment, as the latter is often unsuccessful

217 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023383
2022912
2021582
2020616
2019552
2018576