Statistical hypothesis testing

About: Statistical hypothesis testing is a research topic. Over the lifetime, 19580 publications have been published within this topic receiving 1037815 citations. The topic is also known as: statistical hypothesis testing & confirmatory data analysis.

Invariants of phylogenies in a simple case with discrete states

Abstract: Under a simple model of transition between two states, we can work out the probabilities of different data outcomes in four species with any given phylogeny For a given tree topology, if all characters are evolving under the same probabilistic model, there are two quadratic forms in the frequencies of outcomes that must be zero It may be possible to test the null hypothesis that the tree is of a particular topology by testing whether these quadratic forms are zero One of the tests is a test for independence in a simple 2×2 contingency table If there are differences of evolutionary rate among characters, these quadratic forms will no longer necessarily be zero

A Consensus Combined P-Value Test and the Family-wide Significance of Component Tests

Abstract: SUMMARY A combined P-value test is described that is specifically designed to test the consensus of a set of independent tests, all of which address the same null hypothesis. It is shown that Fisher's combined probability test is unsuitable in this application. A test based on the arithmetic mean of the normaltransformed P-value is shown to properly balance component tests that support or refute a common null hypothesis. A means of determining the family-wide significance of individual tests, which are part of a collection of conceptually related tests, is also described.

Fitting Vast Dimensional Time-Varying Covariance Models

Abstract: Building models for high dimensional portfolios is important in risk management and asset allocation. Here we propose a novel and fast way of estimating models of time-varying covariances that overcome an undiagnosed incidental parameter problem which has troubled existing methods when applied to hundreds or even thousands of assets. Indeed we can handle the case where the cross-sectional dimension is larger than the time series one. The theory of this new strategy is developed in some detail, allowing formal hypothesis testing to be carried out on these models. Simulations are used to explore the performance of this inference strategy while empirical examples are reported which show the strength of this method. The out of sample hedging performance of various models estimated using this method are compared.

Statistical methods for efficiency adjusted real-time PCR quantification.

Abstract: The statistical treatment for hypothesis testing using real-time PCR data is a challenge for quantification of gene expression. One has to consider two key factors in precise statistical analysis of real-time PCR data: a well-defined statistical model and the integration of amplification efficiency (AE) into the model. Previous publications in real-time PCR data analysis often fall short in integrating the AE into the model. Novel, user-friendly, and universal AE-integrated statistical methods were developed for real-time PCR data analysis with four goals. First, we addressed the definition of AE, introduced the concept of efficiency-adjusted Delta Delta Ct, and developed a general mathematical method for its calculation. Second, we developed several linear combination approaches for the estimation of efficiency adjusted Delta Delta Ct and statistical significance for hypothesis testing based on different mathematical formulae and experimental designs. Statistical methods were also adopted to estimate the AE and its equivalence among the samples. A weighted Delta Delta Ct method was introduced to analyze the data with multiple internal controls. Third, we implemented the linear models with SAS programs and analyzed a set of data for each model. In order to allow other researchers to use and compare different approaches, SAS programs are included in the Supporting Information. Fourth, the results from analysis of different statistical models were compared and discussed. Our results underline the differences between the efficiency adjusted Delta Delta Ct methods and previously published methods, thereby better identifying and controlling the source of errors introduced by real-time PCR data analysis.

A systematic review of Bayesian articles in psychology: The last 25 years.

Abstract: Although the statistical tools most often used by researchers in the field of psychology over the last 25 years are based on frequentist statistics, it is often claimed that the alternative Bayesian approach to statistics is gaining in popularity. In the current article, we investigated this claim by performing the very first systematic review of Bayesian psychological articles published between 1990 and 2015 (n = 1,579). We aim to provide a thorough presentation of the role Bayesian statistics plays in psychology. This historical assessment allows us to identify trends and see how Bayesian methods have been integrated into psychological research in the context of different statistical frameworks (e.g., hypothesis testing, cognitive models, IRT, SEM, etc.). We also describe take-home messages and provide "big-picture" recommendations to the field as Bayesian statistics becomes more popular. Our review indicated that Bayesian statistics is used in a variety of contexts across subfields of psychology and related disciplines. There are many different reasons why one might choose to use Bayes (e.g., the use of priors, estimating otherwise intractable models, modeling uncertainty, etc.). We found in this review that the use of Bayes has increased and broadened in the sense that this methodology can be used in a flexible manner to tackle many different forms of questions. We hope this presentation opens the door for a larger discussion regarding the current state of Bayesian statistics, as well as future trends. (PsycINFO Database Record