Showing papers on "Sterculia foetida published in 1974"

Mitogenic activity of sterculic acid, a cyclopropenoid fatty acid.

Abstract: Hepatocytes in rainbow trout and rat are stimulated to augmented DNA synthesis and cell division by low concentrations of cyclopropenoid fatty acids in the diet. Sterculic acid isolated as the methyl ester from Sterculia foetida oil has been identified as one of the mitogenic principles.

Alterations in growth, lipid metabolism and P:O ratios in mice fed Sterculia foetida oil

Abstract: approved: /} U Joseph E. Nucon Cyclopropenoid fatty acids (CPFA) are natural components of cottonseed oil, a major food oil in the United States. The ability of CPFA to cause abnormal biochemical and physiological effects when fed to laboratory and farm animals has prompted an investigation of their effects on mice. Between 0. 05 and 0. 55% CPFA were fed as glycerines ofSterculia foetida oil (SFO, containing 55% CPFA) to mice to determine their effect on certain aspects of growth, lipid metabolism and mitochondrial function. One-half percent SFO fed to weanling mice caused a small temporary decrease in growth rate when compared to controls. Many mice fed 1% SFO stopped growing and died by the end of a 9-week feeding trial. Mice fed less than 1% SFO, or 1% SFO for shorter periods of time, showed increased liver-to-body-weight ratios, accumulation of CPFA in adipose tissue and increased ratios of 16:0/16:1, 18:0/18:1 and total saturated to unsaturated fatty acids in liver and depot fat. Erythrocytes from CPFA-fed mice hemolyzed more slowly than erythrocytes from control mice in isotonicnonelectrolytes, implying an effect of CPFA on membrane lipid compos ition. One-half percent SFO fed for 9 to 31 days inhibited almost completely the incorporation of [ c] from labeled palmitate or acetate into liver monounsaturated fatty acids. At the same time, 0. 5% SFO retarded the incorporation of label from acetate into 14 CO and total liver lipid, but stimulated twofold the incorporation into liver sterols. The oxidation of labeled palmitate was also reduced. CPFA caused lipid accumulation in livers. P:0 ratios of liver mitochondria from mice fed 1% SFO for 6 to 15 days were 1. 061. 45 while control P:0 ratios were Z. 30-2. 85. The decrease was due to decreased phosphorylation, but increased respiration. The relationship between the observed results and membrane fatty acid composition was discussed. Alterations in Growth, Lipid Metabolism and P:0 Ratios in Mice Fed Sterculia foetida Oil by Michael Wesley Lehman A THESIS submitted to Oregon State University in partial fulfillment of the requirements for the degree of Master of Science Completed June 1974 Commencement June 1975