Topic
Steric effects
About: Steric effects is a research topic. Over the lifetime, 16112 publications have been published within this topic receiving 319615 citations. The topic is also known as: steric hindrance.
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TL;DR: The steric parameters common in quantitative structure activity relationships (QSAR), a common method for pharmaceutical function optimization, are reviewed and how they might be applied in asymmetric catalysis, as the two fields are undeniably similar.
Abstract: Many parameters have been designed to describe steric size, but few have been able to explain consistently the selectivity of asymmetric catalytic reactions. Here, Sterimol parameters — originally used to develop quantitative structure–activity relationships in medicinal chemistry — have been used to quantify enantioselectivity in a diverse collection of asymmetric catalytic reactions.
200 citations
TL;DR: Several diorganoscandium complexes stabilized by the β-diketiminato ligands (Ar)NC(R)CHC(R),N(Ar) (Ar = 2,6-iPr-C6H3; R = CH3 (ligand a), R = tBu (ligands b)) have been synthesized as discussed by the authors.
198 citations
TL;DR: In this article, the authors discuss boranes in organic chemistry, diborane as a reducing agent, volatile compounds of uranium, the alkali metal hydride approach to borane, and borohydrides.
Abstract: Publisher Summary This chapter discusses boranes in organic chemistry, diborane as a reducing agent, volatile compounds of uranium, the alkali metal hydride approach to diborane, and alkali metal borohydrides. The search for solvents led to the discovery of sodium borohydride's being an excellent reducing agent for aldehydes and ketones. The search for catalysts to enhance the reducing power of sodium borohydride led to an anomalous result in the reduction of ethyl oleate. Investigation of this anomalous result led to the discovery of hydroboration. Hydroboration made the organoboranes readily available for the first time. This led to a systematic exploration of the chemistry of the organoboranes and established the fact that they constitute the most versatile organometallic available currently. The chapter describes molecular addition compounds and steric strains, steric assistance in solvolysis, the nonclassical ion problem, selective reductions, hydroboration, and versatile organoboranes. On the theoretical side, study of the dissociation of addition compounds of amines with trimethylborane, boron trifluoride, and borane provides a new quantitative approach to steric strains. These studies quickly removed doubts as to the importance of steric effects in chemical behavior and led to the study of related carbon compounds and the establishment of steric effects as an important factor in their behavior. One phase of these studies involved steric assistance to ionization in highly branched tertiary halides and related derivatives.
198 citations
198 citations
TL;DR: An analysis of the binding of 52 sulfate and phosphate ions in 34 protein structures has been carried out, finding patterns in the binary and ternary interactions involving various anions.
195 citations