Topic
Sterol
About: Sterol is a research topic. Over the lifetime, 8117 publications have been published within this topic receiving 309926 citations. The topic is also known as: sterols & sterol lipids.
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TL;DR: The question of whether the diet of human populations at low risk for colon cancer is mirrored in their sterol composition is addressed in this study and it is shown that the absolute amounts of cholesterol consumed as a factor by itself might not be as significant as its relationship to total plant sterols in the diet.
128 citations
TL;DR: Examination of the mass spectrum and nuclear magnetic resonance spectrum of the deuterated 24-ethyl-sterol indicated the Bloch-Cornforth route originating with acetyl-CoA and passing through mevalonic acid to sterol was not operative at this stage of development, and an alternate pathway giving rise to sterols is proposed.
Abstract: Sixty-one sterols and pentacyclic triterpenes have been isolated and characterized by chromatographic and spectral methods fromZea mays (corn) Several plant parts were examined; seed, pollen, cultured hypocotyl cells, roots, coleoptiles (sheaths), and blades By studying reaction pathways and mechanisms on plants fed radiotracers ([2-14C]mevalonic acid, [2-14C]acetate, and [2-3H]acetate), and stable isotopes (D2O), we discovered that hydroxymethylglutaryl CoA reductase is not “the” rate-limiting enzyme of sitosterol production Additionally, we observed an ontogenetic shift and kinetic isotope effect in sterol biosynthesis that was associated with the C-24 alkylation of the sterol side chain Blades synthesized mainly 24α-ethyl-sterols, sheaths synthesized mainly 24-methyl-sterols, pollen possessed an interrupted sterol pathway, accumulating 24(28)-methylene-sterols, and germinating seeds were found to lack an activede novo pathway Shoots, normally synthesizing (Z)-24(28)-ethylidine-cholesterol, after incubation with deuterated water, synthesized the rearranged double-bond isomer, stigmasta-5,23-dien-3β-ol Examination of the mass spectrum and1H nuclear magnetic resonance spectrum of the deuterated 24-ethyl-sterol indicated the Bloch-Cornforth route originating with acetyl-CoA and passing through mevalonic acid to sterol was not operative at this stage of development An alternate pathway giving rise to sterols is proposed
128 citations
TL;DR: A specific and sensitive means of detection of sterol hydroperoxides on irrigated thin-layer chromatoplates using N,N-dimethyl-p-phenylenediamine dihydrochloride has been developed and autoxidation of cholesterol in the solid state, in the irradiated solidState, in colloidal dispersion, and in aerated solution is shown.
128 citations
TL;DR: The manner in which cells retain their sterol content is reviewed and the findings appear to be broadly applicable to conditions in vivo.
128 citations
TL;DR: The steroid esters of Δ5-3β-Hydroxysteroids in Lipoidal Derivatives Synthesized by Lecithin represent substrates for the cholesterol side-chain cleavage enzyme and have unique actions in blood.
Abstract: I. Introduction A. Obfuscating chemistry and the presumptive steroid acetates B. Sterol esters: substrates for the cholesterol side-chain cleavage enzyme II. Lipoidal Derivatives of Δ5-3β-Hydroxysteroids in the Adrenal and Ovary A. Endogenous steroid esters B. Biosynthetic esterification ofΔ 5-3β-hydroxy-steroids III. Lipoidal Derivatives of Steroids in Peripheral Tissues A. Esterification of steroid hormones B. Esterification of Δ5-3β-hydroxysteroids C. Endogenous esters of sex steroids D. Androsterone esters in breast cyst fluid IV. Lipoidal Derivatives Synthesized by Lecithin:Cholesterol Acyltransferase A. Blood B. Ovarian follicular fluid V. Steroid Esterases VI. Lipoidal Derivatives of Steroid Hormones in Insects VII. Biological Effects of Steroid Esterification A. Potent sex steroids B. Unique actions of the steroid esters in blood VIII. Conclusion
128 citations