Topic
Sterol
About: Sterol is a research topic. Over the lifetime, 8117 publications have been published within this topic receiving 309926 citations. The topic is also known as: sterols & sterol lipids.
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TL;DR: Results indicate that the role of ergosterol in stress tolerance is independent of hsps or trehalose.
Abstract: The role of ergosterol in yeast stress tolerance, together with heat shock proteins (hsps) and trehalose, was examined in a sterol auxotrophic mutant of Saccharomyces cerevisiae. Ergosterol levels paralleled viability data, with cells containing higher levels of the sterol exhibiting greater tolerances to heat and ethanol. Although the mutant synthesised hsps and accumulated trehalose upon heat shock to the same levels as the wild-type cells, these parameters did not relate to stress tolerance. These results indicate that the role of ergosterol in stress tolerance is independent of hsps or trehalose.
120 citations
TL;DR: Fan et al. as mentioned in this paper analyzed the free sterol content of cerebrospinal fluid by a combination of charge tagging and liquid chromatography-tandem mass spectrometry, and the most abundant cholesterol metabolites were found to be C27 and C24 intermediates of the bile acid biosynthetic pathways with structures corresponding to 7α-hydroxy-3-oxocholest-4-en-26-oic acid (7.170 ± 2.826 ng/ml, mean ± S.D.
120 citations
TL;DR: The results would suggest that in the liver of patients with gallstones the conversion of cholesterol to bile acids is somewhat reduced, and that changing the bile acid pool composition, by exogenous bile Acid feeding, has disparate effects on hepatic cholesterol synthesis.
119 citations
TL;DR: The suggestion is made that this gland stores specific sterol esters and hydrolyzes chylomicron esters to resynthesize the cholesterol esters characteristic of the gland.
119 citations
TL;DR: A purified (300-fold) liver protein specifically binds squalene and sterol precursors of cholesterol and activates the microsomal enzymic steps of cholesterol biosynthesis in which these precursor participate.
119 citations