Topic
Sterol
About: Sterol is a research topic. Over the lifetime, 8117 publications have been published within this topic receiving 309926 citations. The topic is also known as: sterols & sterol lipids.
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TL;DR: The vertical flux and free steroid alcohol (sterol) and ketone composition of particulate material was determined using sediment traps deployed at 389, 988, 3755 and 5068 m at a station in the equatorial North Atlantic, PARFLUX E. as discussed by the authors.
97 citations
TL;DR: Dietary supplementation with plant sterols, stanols, and their esters reduces intestinal cholesterol absorption, thus lowering plasma LDL cholesterol concentration in humans, and inhibit cholesterol absorption within the intestinal lumen independently of LXR.
Abstract: Dietary supplementation with plant sterols, stanols, and their esters reduces intestinal cholesterol absorption, thus lowering plasma LDL cholesterol concentration in humans. It was suggested that these beneficial effects are attributable in part to induction of genes involved in intestinal cholesterol transport, e.g., Abcg5 and Abcg8, via the liver X receptor (LXR), but direct proof is lacking. Male C57BL/6J mice were fed a purified diet (control), diets containing cholesterol (0.12 g/100 g) only, or in combination with either plant sterols or stanols (0.5 g/100 g) for 4 wk. Plant sterols and stanols dramatically increased neutral fecal sterol excretion (2.2 and 1.4-fold, respectively, compared with cholesterol-fed mice; P < 0.05). Cholesterol and cholesterol ester concentrations were higher in livers of mice fed cholesterol compared with controls (+135% and +925%; P < 0.05). Plant sterols and stanols completely prevented cholesterol accumulation as well as induction of LXR target genes in liver. Feeding plant sterols and stanols did not alter intestinal expression of Abcg5, Abcg8, or other LXR target genes nor of Npc1l1. Fractional cholesterol absorption in Abcg5-/- mice was reduced to the same extent by dietary plant sterols (49%) as in wild-type littermates (44%). Plant sterol and stanol-induced reduction of cholesterol absorption in mice is not associated with upregulation of intestinal LXR target genes nor is it influenced by Abcg5-deficiency. Our data indicate that dietary plant sterols and stanols inhibit cholesterol absorption within the intestinal lumen independently of LXR.
97 citations
TL;DR: An investigation of methods for the extraction and analysis of lipids from human arteries is described, and the analytical procedure developed has been tested for completeness of separation and absence of artefact formation.
Abstract: An investigation of methods for the extraction and analysis of lipids from human arteries is described. The analytical procedure developed has been tested for completeness of separation and absence of artefact formation. It can be applied to lipid mixtures amounting to as little as 50 mg or in some cases even less. The lipids can be separated into phospholipids, free fatty acids, sterol esters, and glycerides plus free sterols, and the fatty acid mixtures from these fractions analysed by gas chromatography after methylation. Examples of such analyses are given.
97 citations
TL;DR: It is argued that B-ring modification predated steroid evolution: non-enzymatic oxidation of membrane sterols primarily results in 7-oxygenation.
97 citations
TL;DR: This review summarizes the current knowledge of a number of non-vesicular transport proteins and how they could contribute to intracellular sterol trafficking and distribution.
97 citations