Topic
Sterol
About: Sterol is a research topic. Over the lifetime, 8117 publications have been published within this topic receiving 309926 citations. The topic is also known as: sterols & sterol lipids.
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TL;DR: In this paper, the role of the Mln64 START domain in sterol metabolism was investigated in mice with a targeted mutation in the START domain, and the mutants were found to have a phenotype similar to that in humans and mice lacking NPC1 or NPC2.
94 citations
TL;DR: Mechanistic insight into the role of plant sterols during endocytosis and the establishment of cell polarity has been obtained and first steps towards in vivo characterization of sterol-enriched membrane domains have been taken.
94 citations
TL;DR: The development, optimization and validation of a methodology to determine nine key steroid hormones expressed in the steroidogenesis in biological fluids and the accuracy was 50–112% in the range 0.10 to 2.00 ng/mL.
Abstract: This paper presents the development, optimization and validation of a methodology to determine nine key steroid hormones (viz. pregnenolone, progesterone, dehydroepiandrosterone, androstenedione, testosterone, dihydrotestosterone, estrone, 17α-estradiol and 17β-estradiol) expressed in the steroidogenesis in biological fluids. The analytical method allows for the determination of steroid hormones in blood plasma and serum down to 0.08-0.16 ng/mL for estrogens, 0.20-0.36 ng/mL for androgens and 0.36-0.43 ng/mL for progestagens. These limits of detection were obtainable using a two-step solid-phase clean-up for fractionation and elimination of interfering lipids (fatty acids, phospholipids, glycerides and sterols) from the steroid hormones. The accuracy of the method was 50-112% in the range 0.10 to 2.00 ng/mL.
94 citations
TL;DR: The data indicate that CDCA suppressed elevated cholesterol and cholestanol synthesis in CTX, and suggest that this primary bile acid may be useful in preventing the clinical progression of this disease.
94 citations
TL;DR: Mutations in the novel gene, ARV1, render cells dependent on sterol esterification for growth, nystatin- sensitive, temperature-sensitive, and anaerobically inviable, and it is proposed that ARV 1 is a novel mediator of eukaryotic sterol homeostasis.
94 citations