Topic
Sterol
About: Sterol is a research topic. Over the lifetime, 8117 publications have been published within this topic receiving 309926 citations. The topic is also known as: sterols & sterol lipids.
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TL;DR: The subject was elucidated still further about a year ago by the investigations of Windaus and Hess and Rosenheim and Webster, who determined that it is ergosterol, a sterol closely allied to cholesterol, which is activated by the ultraviolet rays in this remarkable way.
Abstract: In 1924 it was shown independently by Hess1and by Steenbock2that various foods, such as oils, milk and cereals can be endowed with specific antirachitic properties merely by subjecting them to ultraviolet radiations. The year following, these investigators3found that the substance which undergoes this specific change is a sterol, seemingly cholesterol, which has long been known to be a constituent of every cell in the animal body. These studies and their obvious connotations definitely identified actinotherapy with photochemistry. The subject was elucidated still further about a year ago by the investigations of Windaus and Hess4and of Rosenheim and Webster5who, by means of chemical analyses and spectral absorption tests, determined that it is ergosterol, a sterol closely allied to cholesterol, which is activated by the ultraviolet rays in this remarkable way. Ergosterol was one of the large number of sterols known to
86 citations
TL;DR: It is shown here that macrophages incubated with sitosterol-containing lipoproteins accumulate free sterols and undergo death in the absence of an ACAT inhibitor, establishing two new concepts: first, a relatively subtle change in sterol structure fundamentally alters the type of death program triggered in Macrophages, and second, sitosterl-induced macrophage death does not require ACAT dysfunction and so may occur in an accelerated fashion.
86 citations
TL;DR: Fatty acids are the precursors for oxylipins, including jasmonic acid, and for azelaic Acid, which together with glycerol-3-phosphate are crucial for the regulation of systemic acquired resistance.
86 citations
TL;DR: The results imply that above saturating concentrations of acceptor, acceptor-cell interaction is no longer limiting and that the rate of efflux of cholesterol under such conditions depends on intracellular processes necessary to make cholesterol available to the acceptor.
86 citations
TL;DR: It is concluded that Karlodinium micrum protects itself from the membrane-disrupting properties of its own toxins by possessing a membrane sterol that does not interact with these compounds.
Abstract: The lipophilic toxins from Karlodinium micrum, KmTX, have negative effects on several co-occurring phytoplankton species, yet appear to have no effect on K. micrum itself. One of these compounds, KmTX2, has differing toxicity towards eukaryotic membranes with differing sterol compositions (vertebrate > fungal > dinoflagellate). It is shown that KmTX2 causes lysis in a co-occurring potential grazer Oxyrrhis marina while having no effect on K. micrum itself. K. micrum has a unique membrane sterol profile dominated by (24S)-4α-methyl-5α-ergosta-8(14),22-dien-3β-ol (gymnodinosterol), whereas O. marina was shown to possess 5,22-cholestadien-24β-methyl-3β-ol (brassicasterol) and 5-cholesten-3β-ol (cholesterol) as its major membrane sterols. In accord with toxicity data from whole cells containing these sterols, free sterols were found to inhibit haemolysis in the order cholesterol > ergosterol > gymnodinosterol. It appears that certain sterols can form stable complexes with the toxin molecule, thereby sequester...
86 citations