Topic
Sterol
About: Sterol is a research topic. Over the lifetime, 8117 publications have been published within this topic receiving 309926 citations. The topic is also known as: sterols & sterol lipids.
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TL;DR: Evidence is provided that the biophysical and functional characteristics of the two sterols differ and that the double bond at C24 significantly weakens the sterol ordering potential, and it is suggested that the choice of cholesterol synthesis route may provide a physiological mechanism to modulate raft-dependent functions in cells.
134 citations
TL;DR: In this article, an efficient method for the micro determination of cholesterol and some plant sterols such as brassicasterol, campesterol, stigmasterol, and β-sitosterol is presented.
Abstract: An efficient method has been developed for the microdetermination of cholesterol and some plant sterols such as brassicasterol, campesterol, stigmasterol, and β-sitosterol. The method is a greatly simplified analytical procedure in which samples are directly saponified, the unsaponifiable substances extracted, and the sterols estimated by gas liquid chromatography without further processing. The sterol contents from the new method are at least as high, alid generally higher, than those from the official method, indicating superior recovery. The analysis has been found to be simple, sensitive, economical of time and particularly of solvents. It is probably adaptable to a wide variety of food ingredients or products.
133 citations
TL;DR: It was concluded that diosgenin interferes with the absorption of cholesterol of both exogenous and endogenous origin; such interference is accompanied by derepressed rates of hepatic and intestinal cholesterol synthesis.
133 citations
TL;DR: The fluorescence dips provide compelling evidence that a naturally occurring sterol is regularly distributed at fixed compositional fractions, consistent with the presence of hexagonal super-lattices in the fluid membranes.
Abstract: To investigate the lateral organization of sterols in membranes, the fluorescence intensity of dehydroergosterol at different mole fractions in liquid crystalline dimyristoyl phosphatidylcholine bilayers was examined. A number of intensity drops were observed at specific mole fractions, as predicted from a hexagonal super-lattice model. The fluorescence dips provide compelling evidence that a naturally occurring sterol is regularly distributed at fixed compositional fractions, consistent with the presence of hexagonal super-lattices in the fluid membranes. Regularly distributed regions, however, coexist with irregularly distributed regions. The extent of regular distribution varies periodically with sterol mole fraction and, consequently, similar variations take place in the membrane volume and lipid packing. This level of modulation in local membrane structure by minute changes in sterol concentration should have profound implications for the functional role of cholesterol content in cell membranes.
133 citations
01 Jan 2001
TL;DR: A randomized, controlled, single-blind study with sterol esters and non-esterified plant stanols provided in breakfast cereal, bread and spreads was conducted in this paper.
Abstract: Objectives: To determine the efficacy on plasma cholesterol-lowering of plant sterol esters or non-esterified stanols eaten within low-fat foods as well as margarine. Design: Randomised, controlled, single-blind study with sterol esters and non-esterified plant stanols provided in breakfast cereal, bread and spreads. Study 1 comprised 12 weeks during which sterol esters (2.4 g) and stanol (2.4 g) -containing foods were eaten during 4 week test periods of cross-over design following a 4 week control food period. In Study 2, in a random order cross-over design, a 50% dairy fat spread with or without 2.4 g sterol esters daily was tested. Subjects: Hypercholesterolaemic subjects; 22 in study 1 and 15 in study 2. Main outcome measures: Plasma lipids, plasma sterols, plasma carotenoids and tocopherols. Results: Study 1 — median LDL cholesterol was reduced by the sterol esters (713.6%; P < 0.001 by ANOVA on ranks; P < 0.05 by pairwise comparison) and by stanols (78.3%; P ¼ 0.003, ANOVA and < 0.05 pairwise comparison). With sterol esters plasma plant sterol levels rose (35% for sitosterol, 51% for campesterol; P < 0.001); plasma lathosterol rose 20% (P ¼ 0.03), indicating compensatory increased cholesterol synthesis. With stanols, plasma sitosterol fell 22% (P ¼ 0.004), indicating less cholesterol absorption. None of the four carotenoids measured in plasma changed significantly. In study 2, median LDL cholesterol rose 6.5% with dairy spread and fell 12.2% with the sitosterol ester fortified spread (P ¼ 0.03 ANOVA and < 5% pairwise comparison). Conclusion: 1. Plant sterol esters and non-esterified stanols, two-thirds of which were incorporated into low-fat foods, contributed effectively to LDL cholesterol lowering, extending the range of potential foods. 2. The LDL cholesterol-raising effect of butter fat could be countered by including sterol esters. 3. Plasma carotenoids and tocopherols were not reduced in this study. Sponsorship: Meadow Lea Foods, Australia. Descriptors: sterolesters; sitostanol; low-fat foods; cholesterol European Journal of Clinical Nutrition (2001) 55, 1084–1090
133 citations