Topic
Sterol transport
About: Sterol transport is a research topic. Over the lifetime, 223 publications have been published within this topic receiving 16833 citations.
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TL;DR: Data suggest that ABCG5 and ABCG8 normally cooperate to limit intestinal absorption and to promote biliary excretion of sterols, and that mutated forms of these transporters predispose to sterol accumulation and atherosclerosis.
Abstract: In healthy individuals, acute changes in cholesterol intake produce modest changes in plasma cholesterol levels. A striking exception occurs in sitosterolemia, an autosomal recessive disorder characterized by increased intestinal absorption and decreased biliary excretion of dietary sterols, hypercholesterolemia, and premature coronary atherosclerosis. We identified seven different mutations in two adjacent, oppositely oriented genes that encode new members of the adenosine triphosphate (ATP)-binding cassette (ABC) transporter family (six mutations in ABCG8 and one in ABCG5) in nine patients with sitosterolemia. The two genes are expressed at highest levels in liver and intestine and, in mice, cholesterol feeding up-regulates expressions of both genes. These data suggest that ABCG5 and ABCG8 normally cooperate to limit intestinal absorption and to promote biliary excretion of sterols, and that mutated forms of these transporters predispose to sterol accumulation and atherosclerosis.
1,575 citations
TL;DR: Increased understanding of these processes and their integration at the organ systems level provides fundamental insights into the physiology of cholesterol trafficking.
Abstract: Cholesterol is an essential structural component in the cell membranes of most vertebrates. Increased understanding of the metabolism and functional compartmentalization of cholesterol and how this is related to the organ systems level should provide insights into the physiology of cholesterol trafficking.
1,240 citations
TL;DR: Liscum et al. as mentioned in this paper reviewed the current knowledge of cholesterol transport mecha- nisms and pathways and have described approaches that may help define cholesterol trafficking mechanisms in molecular de- tail.
510 citations
TL;DR: The most prominent and easily measured aspect of sterol movement between HDL and cells is the rapid bidirectional transfer of cholesterol between the lipoprotein and the plasma membrane.
461 citations
TL;DR: The results reveal sterol-enriched early endosomes as targets for BFA interference in plants, suggesting a connection between plant endocytic sterol transport and polar sorting events.
405 citations