Topic
Stigmasterol
About: Stigmasterol is a research topic. Over the lifetime, 1461 publications have been published within this topic receiving 25910 citations. The topic is also known as: (3beta,22E)-stigmasta-5,22-dien-3-ol & poriferasterol.
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TL;DR: Seeds, grains, and legumes are a rich natural source of phytosterols, Additionally, they contain noticeable amounts of squalene and tocopherols, and in general, their fatty acid profile is favorable.
Abstract: The unsaponifiable lipid fraction of plant-based foods is a potential source of bioactive components such as phytosterols, squalene, and tocopherols. The objective of the present study was to determine the levels of phytosterols, and squalene, as well as tocopherols (α and β + γ) in selected grains, seeds, and legumes. The method comprised acid hydrolysis and lipid extraction followed by alkaline saponification, prior to analysis by HPLC. In addition, the fatty acid profile of the foods was determined via total lipid extraction, fatty acid derivitisation and GC analysis. In general, β-sitosterol was the most prevalent phytosterol, ranging in concentration from 24.9 mg/100 g in pumpkin seed to 191.4 mg/100 g in peas. Squalene identified in all foods examined in this study, was particularly abundant in pumpkin seed (89.0 mg/100 g). The sum of α- and β+ γ-tocopherols ranged from 0.1 mg/100 g in rye to 15.9 mg/100 g in pumpkin seeds. Total oil content ranged from 0.9% (w/w) in butter beans to 42.3% (w/w) in pumpkin seed and the type of fat, in all foods examined, was predominantly unsaturated. In conclusion, seeds, grains, and legumes are a rich natural source of phytosterols. Additionally, they contain noticeable amounts of squalene and tocopherols, and in general, their fatty acid profile is favorable.
470 citations
TL;DR: This data indicates that sitosterol and 24-methylcholesterol are able to regulate membrane fluidity and permeability in a similar manner to cholesterol in mammalian cell membranes, and might be specifically required for cell proliferation.
467 citations
TL;DR: This study shows that stigmasterol inhibits several pro-inflammatory and matrix degradation mediators typically involved in OA-induced cartilage degradation, at least in part through the inhibition of the NF-kappaB pathway.
308 citations
TL;DR: The 1H and 13C NMR spectra of sitosterol, stigmasterol, Stigmast-7-en-3β-ol and spinasterol have been unambiguously assigned by use of HOMCOR and HETCOR techniqeus as discussed by the authors.
304 citations
TL;DR: The unsaponifiables from 19 vegetable oils were divided into a sterol and three other fractions by thin-layer chromatography, and campesterol, stigmasterol and β-sitosterol were present in all oils, and a minor amount of cholesterol in majority of the oils.
Abstract: The unsaponifiables from 19 vegetable oils were divided into a sterol and three other fractions by thin-layer chromatography. All except olive and palm kernel oils gave the sterol fraction in a large quantity. Compositions of the sterol fractions were determined by gas liquid chromatography. Identification of each sterol was carried out by gas liquid chromatography and combined gas chromatograph-mass spectrometry. Campesterol, stigmasterol and β-sitosterol were present in all oils, and a minor amount of cholesterol in majority of the oils. Brassicasterol occurrence was widespread but its content was extremely small in oils other than rapeseed oil. Other sterols, presumably δ7-stigmastenol and δ5- and δ7-avenasterol were detected in most of the oils.
297 citations