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Strychnos nux-vomica

About: Strychnos nux-vomica is a research topic. Over the lifetime, 187 publications have been published within this topic receiving 2598 citations.


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Journal ArticleDOI
TL;DR: The results suggest that central and peripheral mechanism are involved in the pain modulation and anti-inflammation effects of brucine and Brucine N-oxide, biochemical mechanisms of bru cine and brucines N -oxide are different even though they are similar in chemical structure.

182 citations

Journal ArticleDOI
TL;DR: It is indicated that the major alkaloids present in the seed of Strychnos nux-vomica are effective against HepG2 cells proliferation, among which brucine proceed HepG 2 cells death via apoptosis, probably through the participation of caspase-3 and cyclooxygenase-2.

136 citations

Journal ArticleDOI
TL;DR: 1H Nuclear magnetic resonance spectrometry and multivariate analysis techniques were applied for the metabolic profiling of three Strychnos species and the principal component analysis (PCA) showed a clear discrimination between all samples, using the three first components.

84 citations

Journal ArticleDOI
TL;DR: This study provides a relevant and comprehensive review of S. nux-vomica L., including its botany, ethnopharmacology, phytochemistry, pharmacology and toxicology, thus providing a foundation for future studies and exploring the detoxification mechanism associated with processing more deeply.
Abstract: Strychnos nux-vomica L. belongs to the genus Strychnos of the family Loganiaceae and grows in Sri Lanka, India and Australia. The traditional medicinal component is its seed, called Nux vomica. This study provides a relevant and comprehensive review of S. nux-vomica L., including its botany, ethnopharmacology, phytochemistry, pharmacology and toxicology, thus providing a foundation for future studies. Up to the present day, over 84 compounds, including alkaloids, iridoid glycosides, flavonoid glycosides, triterpenoids, steroids and organic acids, among others, have been isolated and identified from S. nux-vomica. These compounds possess an array of biological activities, including effects on the nervous system, analgesic and anti-inflammatory actions, antitumor effects, inhibition of the growth of pathogenic microorganisms and regulation of immune function. Furthermore, toxicity and detoxification methods are preliminarily discussed toward the end of this review. In further research on S. nux-vomica, bioa...

76 citations

Journal ArticleDOI
TL;DR: In this paper, the authors investigated the inhibition efficiency of the extract of Strychnos nux-vomica for the corrosion of mild steel in 1 M sulfuric acid using weight loss test (carried out at 303-323 K), electrochemical measurement, and scanning electron microscope (SEM).
Abstract: The inhibition efficiency of the extract of Strychnos nux-vomica for the corrosion of mild steel in 1 M sulfuric acid was investigated using weight loss test (carried out at 303–323 K), electrochemical measurement, and scanning electron microscope (SEM). The results of weight loss studies indicated that the inhibition efficiency increased with inhibitor concentration and the temperature of the system (following Temkin adsorption isotherm). Electrochemical studies proved that the inhibitor acts through mixed mode of inhibition and the inhibitor molecules adsorb on the metal–solution interface. SEM studies supported the adsorption of the inhibitor over the metal surface. The possible active ingredient responsible for the anticorrosion effect is identified as brucine which is isolated and screened for the anticorrosion effect using electrochemical studies and quantum chemical studies. The possible mode of corrosion inhibition of brucine is also derived using FT-IR studies.

75 citations

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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20212
20205
20194
20182
20177
201611