Showing papers on "Strychnos nux-vomica published in 2003"
TL;DR: The results suggest that central and peripheral mechanism are involved in the pain modulation and anti-inflammation effects of brucine and Brucine N-oxide, biochemical mechanisms of bru cine and brucines N -oxide are different even though they are similar in chemical structure.
182 citations
TL;DR: From seeds of Strychnos nux-vomica three iridoids were isolated together with two known iridoid glucosides, loganic acid and 7-O-acetylloganic acid, establishing the structures of the compounds.
42 citations
TL;DR: A quantitative analysis using (1)H-N MR (Q-NMR) has been developed for the determination of strychnine and brucine in Strychnos nux-vomica seeds and stems.
Abstract: A quantitative analysis using (1)H-NMR (Q-NMR) has been developed for the determination of strychnine and brucine in Strychnos nux-vomica seeds and stems. The advantages of the method are that no reference alkaloids are needed for calibration curves, the quantification could be directly realized on a crude extract, strychnine and brucine could easily be distinguished, an overall profile of the preparation (including non alkaloid compounds) could be directly obtained, and a very significant time-gain could be achieved, in comparison to conventional HPLC methods, for instance.
42 citations
TL;DR: A new capillary electrophoresis procedure with field-enhanced stacking concentration for the analysis of strychnine and brucine is established and can be separated within 5 min and quantified with high sensitivity.
Abstract: A new capillary electrophoresis procedure with field-enhanced stacking concentration for the analysis of strychnine and brucine is established. After optimization of the separation and concentration conditions, the two alkaloids can be separated within 5 min and quantified with high sensitivity (The detection limits were 1.0 ng mL−1 for strychnine and 1.4 ng mL−1 for brucine). The method was useful for qualitative and quantitative analysis of strychnine and brucine in Strychnos nux-vomica L with recovery of 105.1% for strychnine and 98.4% for brucine.
22 citations
Journal Article•
TL;DR: The RP-HPLC method is a good reference for pharmacokinetics in human bodies and can be used to study the pharmacokinetic process about the concentration in rat plasma of the alkaloids from processed seeds of Strychnos nux-vomica with RP- HPLC method.
Abstract: AIM To study the pharmacokinetic process about the concentration in rat plasma of the alkaloids from processed seeds of Strychnos nux-vomica with RP-HPLC method. METHODS Hypersil BDS C18 column was used and the mobile phase consisted of acetonitrile-water at the flow rate of 0.8 mL.min-1. The UV detection wave length was 254 nm. RESULTS The concentration-time data of strychnine, brucine, strychnine N-oxide and brucine N-oxide were all in accordance with an open two-compartment model after i.v. alkaloids. Their parameters were as follows: T1/2 alpha were (8 +/- 5), (4 +/- 3), (6.2 +/- 1.7) and (3.0 +/- 0.8) min, T1/2 beta were (262 +/- 125), (416 +/- 131), (285 +/- 50) and (342 +/- 141) min, CL were (17 +/- 4), (21 +/- 12), (1.9 +/- 1.8) and (2.8 +/- 1.1) mL.min-1, Vc were (1.4 +/- 0.5), (1.7 +/- 1.1), (0.24 +/- 0.16) and (0.23 +/- 0.06) L.kg-1, Vd were (6.0 +/- 1.2), (12 +/- 7), (0.8 +/- 0.6) and (1.5 +/- 0.6) L.kg-1, AUC were (57,578 +/- 25,578), (35,240 +/- 15,616), (93,088 +/- 22,375) and (177,712 +/- 120,110) h.microgram.L-1, respectively. CONCLUSION The method is a good reference for pharmacokinetics in human bodies.
13 citations
TL;DR: Because water channel proteins or aquaporins are mainly responsible for water transport through the plasma membrane of RBCs, it is thought that potentized drugs interact with these proteins, thereby facilitating water influx in the cells.
Abstract: Objectives: The primary biomolecular target of a homeopathic potency is unknown. If it is a plasma membrane protein such as water-channel protein, the drug would alter water permeation in cells. Therefore, the objective is to see if potentized homeopathic drugs like Mercuric chloride 30c and Nux vomica 30c could alter permeation of water through the erythrocytes of a fresh water fish under acute ethanol intoxication. Location: The work was carried out in the Zoology Laboratory of Visva Bharati University, Santiniketan, West Bengal, India. Subject: Live freshwater catfish. Design: Erythrocytes collected from fish with and without ethanol intoxication were incubated in distilled water at 30°C for 30 minutes with Ethanol 30c (control), Merc cor 30c (test 1), and Nux vomica 30c (test 2). Merc cor 30c and Nux vom 30c were prepared by successive dilution of the respective mother tinctures with 90% ethanol (1:100) followed by sonication at 20 kHz for 30 seconds in 30 steps. Ethanol 30c was prepared in the same w...
12 citations
Patent•
26 Dec 2003TL;DR: A polyherbal preparation for the prevention of atherosclerosis and hyperlipidemia comprising a mixture of Commiphora mukul, Boswellia serrata, Semecarpus anacardium Strychnos nux vomica, Termenalia arjuna and Shankha Bhusma is described in this paper.
Abstract: A polyherbal preparation for the prevention of atherosclerosis and hyperlipidemia comprising a mixture of Commiphora mukul, Boswellia serrata, Semecarpus anacardium Strychnos nux vomica, Termenalia arjuna and Shankha Bhusma.
6 citations
Patent•
19 Nov 2003
TL;DR: A process for preparing Chinese medicine "Fengshi Maqian capsule" for treating rheumatic arthritis, rheumatoid disease, and ischias includes such steps as pulverizing 5 Chinese-medicinal materials including vomiting nut, seeping and extracting of ephedra and atractylodes rhizome in alcohol, recovering alcohol, decocting liquorice root and drying, mixing all together, and loading in capsules as mentioned in this paper.
Abstract: A process for preparing Chinese medicine "Fengshi Maqian capsule" for treating rheumatic arthritis, rheumatoid disease, and ischias includes such steps as pulverizing 5 Chinese-medicinal materials including vomiting nut, seeping and extracting of ephedra and atractylodes rhizome in alcohol, recovering alcohol, decocting liquorice root and drying, mixing all together, and loading in capsules. Its advantage is high curative effect and safety.
3 citations