Showing papers on "Strychnos nux-vomica published in 2006"
TL;DR: It is indicated that the major alkaloids present in the seed of Strychnos nux-vomica are effective against HepG2 cells proliferation, among which brucine proceed HepG 2 cells death via apoptosis, probably through the participation of caspase-3 and cyclooxygenase-2.
136 citations
TL;DR: Ca2+ and Bcl-2 mediated mitochondrial pathway were found to be involved in brucine-induced HepG2 cell apoptosis, and suggested a pivotal role of mitochondrial membrane depolarization in HepG1 cell apoptotic programmed cell death elicited by Brucine.
65 citations
TL;DR: Most strikingly, quaternization of strychnine and brucine with substituents possessing different steric and electronic properties completely eliminated the activity at the glycine receptors, whereas binding affinity to the alpha7/5-HT3 chimera was retained for the majority of the quaternary analogues.
44 citations
TL;DR: The results of this study show that the use of this type of preparation by athletes can lead to a positive doping case.
31 citations
TL;DR: An easy, rapid method for simultaneous determination of strychnine and brucine in Strychnos nux-vomica L. and its preparation was developed by nonaqueous capillary electrophoresis (NACE) without pretreatment for the first time.
28 citations
TL;DR: A nonaqueous capillary electrophoresis method with photo diode-array detection was developed for the analysis of strychnine and brucine in Strychnos nux-vomica L..
Abstract: A nonaqueous capillary electrophoresis method with photo diode-array detection was developed for the analysis of strychnine and brucine in Strychnos nux-vomica L. The separation of the two alkaloids was optimized with respect to the concentration of Tris-boric acid, the proportion of methanol and acetonitrile, and applied voltage. Baseline separation was obtained for the two analytes within 10 min using a running buffer containing 25 mM Tris-boric acid, 60% methanol and 20% acetonitrile with acetic acid adjusting pH to 4.0. In this paper, the method was used to determine the contents of strychnine and brucine in raw material and prepared Strychnos nux-vomica L.
11 citations
TL;DR: The case of a 35 year-old man suffering from Reiter's disease did not respond to Lycopodium or Nux vomica in medium dilutions, but did respond to Nux vomitica in very high potency.
6 citations