Showing papers on "Strychnos nux-vomica published in 2007"
TL;DR: It is indicated that the major alkaloids present in the seed of Strychnos nux-vomica are effective against SMMC-7721 cells proliferation, among which brucine proceeds SMMC 7721 cells death via apoptosis, probably through the participation of caspase 3 and cyclooxygenase 2.
46 citations
TL;DR: Experimental results indicated that the direct MALDI-TOFMS analysis allowed rapid screening of the alkaloid components in Strychnos nux-vomica seeds.
40 citations
TL;DR: An overview of recent studies on the synthesis of strychnine can be found in this paper, where the authors provide an overview of polycyclization reactions utilized for stryhnine synthesis.
Abstract: Publisher Summary This chapter provides an overview of recent studies on the synthesis of strychnine. Seeds of Strychnos nux vomica , which are the source of the notorious poison strychnine, were used as a traditional poison. Strychnine poisoning can be fatal to humans and can be introduced to the body by inhalation, swallowing, or absorption through the eyes or mouth. It produces some of the best-known, most dramatic, terrifying, and painful symptoms imaginable. The Strychnos alkaloids constitute an important group of architecturally complex and widely distributed monoterpenoid indole alkaloids. The structural complexity of strychnine, coupled with its biological activity, has served as the impetus for numerous synthetic investigations. The polycyclization reactions utilized for strychnine synthesis are classified according to the reaction type. Magnus and Fukuyama employed the transannular cyclization of similar iminium ion intermediates, leading to two-ring and three-ring formation, respectively. In Stork's and Martin's syntheses, Harley-Mason's skeletal rearrangement strategy was used to close the C and E rings. Domino cyclizations developed by Overman and Kuehne involve both [3,3]sigmatropic rearrangement and the Mannich reaction.
6 citations