Topic
Strychnos nux-vomica
About: Strychnos nux-vomica is a research topic. Over the lifetime, 187 publications have been published within this topic receiving 2598 citations.
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TL;DR: A patient with mild strychnine poisoning with bradycardia is reported, a rare method of deliberate self-harm in adults.
Abstract: Strychnine poisoning is a rare method of deliberate self-harm in adults. Poisoning with strychnine leaves is a rare form of strychnine poisoning, as the usual plant parts used are nuts, bark, and seeds. Although the common cardiac manifestations of strychnine positioning include tachycardia and hypertension, we report a patient with mild strychnine poisoning with bradycardia.
2 citations
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TL;DR: An easy and rapid method based on hydrophilic-interaction chromatography has been developed and validated for measurement of two major alkaloids, strychnine and brucine, in Strychnos nux-vomica plant seeds and preparations as mentioned in this paper.
Abstract: An easy and rapid method based on hydrophilic-interaction chromatography has been developed and validated for measurement of two major alkaloids, strychnine and brucine, in Strychnos nux-vomica plant seeds and preparations. The seeds were processed in different ways. Separation was performed at ambient temperature on a carbohydrate column with acetonitrile–water 90:10 (v/v) as mobile phase at a flow rate of 1.0 mL min−1. Detection was at 254 nm. Calibration plots were linear over the range 0.1–200 μg mL−1 for both compounds. Average recoveries of strychnine and brucine from spiked samples were 99.9 and 98.5%, respectively.
2 citations
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TL;DR: A novel indolomonoterpenic alkaloid, 4-hydroxy-19-methyl-16,19-seco-12,24-sec-strychnidine-10,16-dione (1), together with three known compounds 2-4 (vomicine, strychnine, and brucine), have been isolated from processed Strychnos nux-vomica as discussed by the authors.
Abstract: A novel indolomonoterpenic alkaloid, 4-hydroxy-19-methyl-16,19-seco-12,24-seco-strychnidine-10,16-dione (1), together with three known compounds 2–4 (vomicine, strychnine, and brucine), have been isolated from processed Strychnos nux-vomica. Its structure was determined by detailed spectral analysis (1H NMR,13C NMR, 1H–1H COSY, HMBC, and HR-ESI-MS).
2 citations
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TL;DR: In this article, the content and encapsulation efficiency of liposomes containing total alkaloids from seed of Strychnos nux-vomica L were established.
Abstract: Objective To establish the method to determine the content and encapsulation efficiency of liposomes containing total alkaloids from seed of Strychnos nux-vomica L.Methods The total alkaloids were extracted from seeds of Strychnou nux-vomica L.and the content was analyzed.Liposomes containing the total alkaloids were prepared by ammonium sulfate transmembrane gradients.The total alkaloid content of dissolved liposomes was determined by UV spectrophotometry at 254 nm,which was performed with strychnine as the reference substances.The encapsulated and free drugs were separated with Sephadex G-50 column,and then their contents were determined to calculate the encapsulation efficiency.Results The average extracted efficiency of total alkaloids from seed of Strychnos nux-vomica L.was 3.49 %.Strychnine and brucine accounted for 46.76 % and 26.51 % in the extract,respectively.Strychnine at the concentration of 2.4-20 μ g/mL had a good linear relationship with the absorbance.The recovery of strychnine was in the range from 96.66 % to 102.62 %.The recovery of Sephadex G-50 column was(100.85± 0.79) %(n=3).Conclusion The established method is simple,accurate and stable,and can be used for the quality control of liposomes containing total alkaloids from seed of Strychnos nux-vomica L.
1 citations
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23 Aug 1975
1 citations