scispace - formally typeset
Search or ask a question
Topic

Strychnos nux-vomica

About: Strychnos nux-vomica is a research topic. Over the lifetime, 187 publications have been published within this topic receiving 2598 citations.


Papers
More filters
Journal ArticleDOI
TL;DR: A patient with mild strychnine poisoning with bradycardia is reported, a rare method of deliberate self-harm in adults.
Abstract: Strychnine poisoning is a rare method of deliberate self-harm in adults. Poisoning with strychnine leaves is a rare form of strychnine poisoning, as the usual plant parts used are nuts, bark, and seeds. Although the common cardiac manifestations of strychnine positioning include tachycardia and hypertension, we report a patient with mild strychnine poisoning with bradycardia.

2 citations

Journal ArticleDOI
TL;DR: An easy and rapid method based on hydrophilic-interaction chromatography has been developed and validated for measurement of two major alkaloids, strychnine and brucine, in Strychnos nux-vomica plant seeds and preparations as mentioned in this paper.
Abstract: An easy and rapid method based on hydrophilic-interaction chromatography has been developed and validated for measurement of two major alkaloids, strychnine and brucine, in Strychnos nux-vomica plant seeds and preparations. The seeds were processed in different ways. Separation was performed at ambient temperature on a carbohydrate column with acetonitrile–water 90:10 (v/v) as mobile phase at a flow rate of 1.0 mL min−1. Detection was at 254 nm. Calibration plots were linear over the range 0.1–200 μg mL−1 for both compounds. Average recoveries of strychnine and brucine from spiked samples were 99.9 and 98.5%, respectively.

2 citations

Journal ArticleDOI
TL;DR: A novel indolomonoterpenic alkaloid, 4-hydroxy-19-methyl-16,19-seco-12,24-sec-strychnidine-10,16-dione (1), together with three known compounds 2-4 (vomicine, strychnine, and brucine), have been isolated from processed Strychnos nux-vomica as discussed by the authors.
Abstract: A novel indolomonoterpenic alkaloid, 4-hydroxy-19-methyl-16,19-seco-12,24-seco-strychnidine-10,16-dione (1), together with three known compounds 2–4 (vomicine, strychnine, and brucine), have been isolated from processed Strychnos nux-vomica. Its structure was determined by detailed spectral analysis (1H NMR,13C NMR, 1H–1H COSY, HMBC, and HR-ESI-MS).

2 citations

Journal Article
Qi Yan1
TL;DR: In this article, the content and encapsulation efficiency of liposomes containing total alkaloids from seed of Strychnos nux-vomica L were established.
Abstract: Objective To establish the method to determine the content and encapsulation efficiency of liposomes containing total alkaloids from seed of Strychnos nux-vomica L.Methods The total alkaloids were extracted from seeds of Strychnou nux-vomica L.and the content was analyzed.Liposomes containing the total alkaloids were prepared by ammonium sulfate transmembrane gradients.The total alkaloid content of dissolved liposomes was determined by UV spectrophotometry at 254 nm,which was performed with strychnine as the reference substances.The encapsulated and free drugs were separated with Sephadex G-50 column,and then their contents were determined to calculate the encapsulation efficiency.Results The average extracted efficiency of total alkaloids from seed of Strychnos nux-vomica L.was 3.49 %.Strychnine and brucine accounted for 46.76 % and 26.51 % in the extract,respectively.Strychnine at the concentration of 2.4-20 μ g/mL had a good linear relationship with the absorbance.The recovery of strychnine was in the range from 96.66 % to 102.62 %.The recovery of Sephadex G-50 column was(100.85± 0.79) %(n=3).Conclusion The established method is simple,accurate and stable,and can be used for the quality control of liposomes containing total alkaloids from seed of Strychnos nux-vomica L.

1 citations

Network Information
Related Topics (5)
Glycoside
4.6K papers, 80.8K citations
78% related
Akuammine
9 papers, 179 citations
77% related
Alkaloid
520 papers, 15.8K citations
76% related
Pharmacognosy
373 papers, 11.8K citations
76% related
Bacopaside
18 papers, 548 citations
76% related
Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20212
20205
20194
20182
20177
201611