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Strychnos nux-vomica

About: Strychnos nux-vomica is a research topic. Over the lifetime, 187 publications have been published within this topic receiving 2598 citations.


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01 Oct 2011
TL;DR: From the experimental studies, it was evident that the LD-50 in detoxified form of both the test drugs found greater than crude materials.
Abstract: Acute oral toxicity studies on the suspension of some Unani drugs Azaraqi (Strychnos nux-vomica Linn.) and Sammulfar (Arsenious oxide) were carried out on mice and compared to detoxified form. The effect of detoxifying process was assessed on the maximum tolerance dose of the test drugs gets affected during the treatment process. From the experimental studies it was evident that the LD-50 in detoxified form of both the test drugs found greater than crude materials.

1 citations

Journal ArticleDOI
TL;DR: In this article, an accurate capillary electrophoresis method was developed for the determination of dissociation constants of five Strychnos alkaloids from Nux-vomica L. The method relies on measuring the effective mobility of the solute as a function of the buffer pH.
Abstract: An accurate capillary electrophoresis method was developed for the determination of dissociation constants of five Strychnos alkaloids from Strychnos nux-vomica L. The method relies on measuring the effective mobility of the solute as a function of the buffer pH. The mathematical relationship was strictly derived from the fundamental electrophoresis theory and the dissociation equilibrium of a weak base without any simplifications. Careful optimization of the running buffer permitted base-line resolution of the five structurally similar alkaloids.

1 citations

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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20212
20205
20194
20182
20177
201611