Topic
Strychnos nux-vomica
About: Strychnos nux-vomica is a research topic. Over the lifetime, 187 publications have been published within this topic receiving 2598 citations.
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TL;DR: A procedure for quantitative estimation of strychnine and brucine in the extracts of Strychnos nux-vomica seeds by capillary zone electrophoresis (CZE) was developed and is useful for the qualitative and quantitative determination in plant drug samples, as well as in human plasma.
Abstract: A procedure for quantitative estimation of strychnine and brucine in the extracts of Strychnos nux-vomica seeds by capillary zone electrophoresis (CZE) was developed. The buffer solution used was 10mM phosphate buffer-MeOH (9 :1), pH 2.5. The linear calibration range was 0.01 - 0.15 mg/ml. This method is useful for the qualitative and quantitative determination of strychnine and brucine in plant drug samples, as well as in human plasma.
25 citations
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TL;DR: Brucine (2,3-dimethoxystrychnidin1 O-one), an alkaloid originally isolated by Pelletier and Caventou in 1819 from the dry ripe seeds of Strychnos nux-vomica L. (Loganiaceae), has long been characterized as strychnine-like in regard to its pharmacologic and toxicologic effects but less potent than stryhnine (Sax and Lewis, 1989).
24 citations
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TL;DR: It has been found that the detoxification processes studied reduce the strychnine content, as determined either by using uv-vis spectrophotometer or HPLC, present in Strychnos nux vomica seeds which is responsible for Stryhnos nUX vomica toxicity.
Abstract: Some plants used in Unani system of medicine are toxic, even deadly poison. The drugs having such plants as their components are detoxified before they are dispensed to the patients. One such drug, capsule Hudar, has Strychnos nux-vomica L. (Azraqi) seeds as one of its components and is very effectively used to elevate blood pressure. Ancient manuscripts describe many methods of its detoxification. It has been found that the detoxification processes studied reduce the strychnine amount, as determined either by using uv-vis spectrophotometer or HPLC, present in Strychnos nux vomica seeds which is responsible for Strychnos nux vomica toxicity. The decrease in strychnine amount was maximum when the seeds were immersed for detoxification in excess of water for 5 days, in milk for 2 days followed by their boiling in milk. Strychnine in small amounts has been reported to give subjective feeling of stimulation
23 citations
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TL;DR: A new capillary electrophoresis procedure with field-enhanced stacking concentration for the analysis of strychnine and brucine is established and can be separated within 5 min and quantified with high sensitivity.
Abstract: A new capillary electrophoresis procedure with field-enhanced stacking concentration for the analysis of strychnine and brucine is established. After optimization of the separation and concentration conditions, the two alkaloids can be separated within 5 min and quantified with high sensitivity (The detection limits were 1.0 ng mL−1 for strychnine and 1.4 ng mL−1 for brucine). The method was useful for qualitative and quantitative analysis of strychnine and brucine in Strychnos nux-vomica L with recovery of 105.1% for strychnine and 98.4% for brucine.
22 citations
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TL;DR: The chemical composition of polysaccharide fractions from Strychnos nux-vomica and S. innocua seeds and comparison with those from S. potatorum seeds are reported and the structural features of the galactomannans from the three Stryhnos species are discussed.
21 citations