Showing papers on "Strychnos potatorum published in 2007"
TL;DR: In this article, the authors dealt with the phytochemical screening of therapeutic importance from Strychnos potatorum L.f., an important medicinal plant, and the generated data has provided the basis for its wide use as the therapeutant both in the traditional and folk medicines.
Abstract: The present paper deals with the phytochemical screening of therapeutic importance from Strychnos potatorum L.f., an important medicinal plant. This study involves the preliminary screening, quantitative determination and the qualitative thin layer chromatographic separation of secondary metabolites from the root, stem bark and seeds (collected and market) of S.potatorum. Further, HPLC alkaloid profile of the seed has been studied. The generated data has provided the basis for its wide use as the therapeutant both in the traditional and folk medicines.
143 citations
TL;DR: Results indicate that SPP and SPE exhibit antiulcerogenic activity by both antisecretory and mucoprotective actions, and may be due to the presence of polysaccharides in seeds.
36 citations
TL;DR: Both SPP and SPE exhibited anti-inflammatory activity in acute and subacute inflammatory models, whereas SPE-II was found to possess maximum activity and its effect was also comparable with the standard drug diclofenac sodium.
Abstract: The anti-inflammatory effect of seed powder [SPP I (100 mg/kg) and II (200 mg/kg) p.o.] and aqueous extract [SPE I (100 mg/kg) and II (200 mg/kg) p.o.] of Strychnos potatorum. Linn (Loganiaceae) seeds was studied in carrageenin-induced hind paw edema and cotton pellet granuloma models. In carrageenin-induced rat paw edema model, both SPP (I and II) and SPE (I and II) exhibited mild inhibition at 1 h and maximum inhibition at 2.5 h in a dose-dependent manner. In the cotton pellet granuloma model, both wet and dry weights of the cotton pellets were significantly (p < 0.001) inhibited by SPP and SPE at both dose levels, whereas a maximum (p < 0.001) inhibition of wet and dry weights was found at 200 mg/kg, p.o. Both SPP and SPE were found to normalize the increased alkaline, acid phosphatases, and lipid peroxide levels indicating their membrane stabilization and free radical scavenging properties, respectively. In conclusion, both SPP (I and II) and SPE (I and II) exhibited anti-inflammatory activity...
8 citations
01 Jan 2007
TL;DR: Body and accessory reproductive organ weight, serum testosterone level, biochemical analysis and histological examinations were carried out and S. potatorum seed extract also affects the accessory reproductive organs with its contraceptive efficacy of male rats.
Abstract: To control the problem of population explosion, investigations are undertaken to discover an effective contraceptive drug. In our previous study Strychnos potatorum seeds have shown contraceptive efficacy in male albino rats. The present study is an attempt to evaluate the effect of 70% methanol seed extract of Strychnos potatorum at the dose level of 100 mg/rat/day on sex accessory organs of male rats. For this, body and accessory reproductive organ weight, serum testosterone level, biochemical analysis and histological examinations were carried out to assess the effect of S. potatorum. Treatment did not bring any significant change in the body weight, whereas the weights of epididymides, seminal vesicles, ventral prostates and vas deferens decreased significantly (P<0.01). Testosterone concentration of serum depleted by 56.60%. Biochemical parameters also showed significant decline in treated group. Disorganization of epithelial layer of cauda epididymis and reduced concentration of secretory fluid in seminal vesicle and in ventral prostate could also be seen. In conclusion S. potatorum seed extract also affects the accessory reproductive organs with its contraceptive efficacy of male rats.
4 citations