Showing papers on "Strychnos potatorum published in 2010"

Evaluation of antiarthritic activity of Strychnos potatorum Linn seeds in Freund's adjuvant induced arthritic rat model

Abstract: Strychnos potatorum Linn (Loganiaceae) is a moderate sized tree found in southern and central parts of India, Sri Lanka and Burma. In traditional system of medicine, Strychnos potatorum Linn seeds were used for various ailments including inflammation, diabetes etc. To investigate the folkloric use of the seeds the present study was carried out on Freund's adjuvant induced arthritic rats. The present study states the effect of the aqueous extract (SPE) and the whole seed powder (SPP) of Strychnos potatorum Linn seeds on the Freund's complete adjuvant (FCA) induced arthritic rat paw edema, body weight changes and alterations in haematological and biochemical parameters in both developing and developed phases of arthritis. Histopathology of proximal interphalangeal joints and radiology of hind legs were studied. In FCA induced arthritic rats, there was significant increase in rat paw volume and decrease in body weight increment, whereas SPP and SPE treated groups, showed significant reduction in paw volume and normal gain in body weight. The altered haematological parameters (Hb, RBC, WBC and ESR) and biochemical parameters (blood urea, serum creatinine, total proteins and acute phase proteins) in the arthritic rats were significantly brought back to near normal by the SPP and SPE treatment at the dose of 200 mg/kg/p.o in both developing and developed phases of arthritis. Further the histopathological and radiological studies revealed the antiarthritic activity of SPP and SPE by indicating fewer abnormalities in these groups when compared to the arthritic control group. In conclusion, both SPP and SPE at the specified dose level of 200 mg/kg, p.o. showed reduction in rat paw edema volume and it could significantly normalize the haematological and biochemical abnormalities in adjuvant induced arthritic rats in both developing and developed phases of FCA induced arthritis. Further the histopathological and radiological studies confirmed the antiarthritic activity of SPP and SPE.

IN VITRO ANTHELMINTIC ACTIVITY OF CRUDE EXTRACTS AND ALKALOID FRACTIONS FROM STRYCHNOS POTATORUM L.f.

Abstract: Summary The solvent successive crude extracts viz . petroleum ether, chloroform, ethanol and water from the root, stem bark, seed, and also seven indole type alkaloid fractions separated by column chromatogram from the seed of Strychnos potatorum L.f. (Loganiaceae) were screened for anthelmintic activity against a nematode pathogen, Heterorhabditis indicus Poinar in vitro at the concentration 1.0 mg/ml. The findings have revealed that all organic plant crude extracts and more particularly the ethanol extracts were showed significant activity (75 6 100%) in terms of observed paralysis and/or mortality of the parasite tested at room temperature (27± 2 o C) after 2h. Further, PB 6 IV fraction (diaboline), the most abundant indole alkaloid has shown considerable paralytic and/or mortality activity ( ≥ 50%) which is comparable to that of albendazole drug, included as positive control.

Antihyperglycemic Activity of Strychnos potatorum Seed and Leaf Methanolic Extracts in Alloxan-Induced Diabetic Rats

Abstract: The pharmacognostic and phytochemical examinations of different solvents extracts of seeds and leaves of Strychnos potatorum were conducted and their antidiabetic activity was evaluated.The administration of methanolic extracts of seeds and leaves of Strychnos potatorum by oral route at doses; 200 and 400 mg/kg b.w. at every 3 hour interval reduced blood glucose levels by24.23%, 25.67%, 16.47% and 17.88%, respectively in alloxan-induced diabetic rats.