Topic
Substituent
About: Substituent is a research topic. Over the lifetime, 42877 publications have been published within this topic receiving 516716 citations. The topic is also known as: side chain & side group.
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Patent•
01 Oct 1999
TL;DR: The structural variants of the ER ligands of this invention exhibit a spectrum of selective affinities for ERα and ERβ and a spectrumof agonist/antagonist properties as mentioned in this paper.
Abstract: This invention provides non-steroidal estrogen receptor ligands having a modular structure that is amenable to solid phase synthesis and the application of combinatorial synthetic methods to prepare these estrogen receptor ligands. ER ligands of this invention consist of a core scaffold that is a carbocyclic or heterocyclic-5-member ring that has two double bonds or a 6-member aromatic ring. A plurality of selected substituents are bonded to the ring substantially independently of other substituents. The modular structure of these compounds allows for synthesis of a very large numer of substituent structural variations, substituent combinations and substituent positioning on the core. The structural variants of the ER ligands of this invention exhibit a spectrum of selective affinities for ERα and ERβ and a spectrum of agonist/antagonist properties.
82 citations
TL;DR: The addition of a β C-H bond to the formyl group of aldehydes to olefins with the aid of Ru(H)2(CO)(PPh3)3 as a catalyst was reported in this article.
Abstract: The addition of a β C–H bond to the formyl group of aldehydes to olefins took place with the aid of Ru(H)2(CO)(PPh3)3 as a catalyst. Several olefins can be used in the catalytic reaction of conjugate enals. The presence of a sterically hindered substituent at the ortho position of benzaldehyde and the presence of an electron donating substituent appear to be important factor in accomplishing the desired coupling reaction.
82 citations
82 citations
82 citations
TL;DR: A quantitative analysis of the structure-activity relationship in cholinesterase inhibitors was made and it is shown by means of substitution constants and regression analysis that the effects of substituent groups can be factored into three groups: electronic, steric, hydrophobic.
82 citations