Topic
Substituent
About: Substituent is a research topic. Over the lifetime, 42877 publications have been published within this topic receiving 516716 citations. The topic is also known as: side chain & side group.
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75 citations
TL;DR: In this paper, the hydrolysis of four substituted phenyl phosphate monoesters, each coordinated to a dinuclear Co(III) complex, was studied, and the results showed that Co2(tacn)2(OH)2{O3P(OAr)}]2+ = 1,4,7-triazacyclonononane; substituent
Abstract: Hydrolysis of four substituted phenyl phosphate monoesters, each coordinated to a dinuclear Co(III) complex, was studied ([Co2(tacn)2(OH)2{O3P(OAr)}]2+; tacn = 1,4,7-triazacyclononane; substituent ...
75 citations
Journal Article•
TL;DR: In this paper, a series of alkyl, aryl, dialkyl and aryal-alkyl carbamic esters of phenols containing a basic substituent directly or indirectly attached to the phenyl radicle have been examined for physostigmine-like action, the toxicities, miotic action and effect on intestinal peristalsis being tabulated.
Abstract: 1. A series of alkyl, aryl, dialkyl and aryl-alkyl carbamic esters of phenols containing a basic substituent directly or indirectly attached to the phenyl radicle have been examined for physostigmine-like action, the toxicities, miotic action and effect on intestinal peristalsis being tabulated. 2. Several related compounds which do not contain both a carbamic ester group and a basic substituent show no activity. 3. The physostigmine-action is strong in methyl-, dimethyl-, allyl-, benzyl- and methylphenyl-carbamic esters of phenol-bases, weak in ethyl- and phenyl- and absent in diethyl and diallylcarbamic esters of this series. The esters of disubstituted carbamic acids are stable. 4. The quaternary salts of the aromatic bases were more active than the hydrochlorides of the corresponding tertiary bases. When the basic radicle was in the side chain the difference was less marked or reversed. 5. The dimethyl- and methylphenyl-carbamic esters of 3-oxyphenyl-trimethylammonium methylsulfate have been fully investigated. They are at least as active as physostigmine in stimulating intestinal peristalsis. The miotic activity of the dimethylcarbamic ester is similar to that of physostigmine, that of the methyl-phenyl-carbamic ester being weak. The latter does not show an antagonistic action to curare. The symptoms produced by toxic doses are similar to those produced by physostigmine.
75 citations
TL;DR: The first covalent selenium azide 2-Me2NCH2C6H4SeN3 has been synthesized and fully characterized including crystal structure determination, resulting in a heterocyclic zwitterionic structure.
Abstract: The first covalent selenium azide 2-Me2NCH2C6H4SeN3 has been synthesized and fully characterized including crystal structure determination. As shown by the experimental results, the relative stability of RSeN3 highly depends on the nature of the coordinating ability of the substituent R, resulting in a heterocyclic zwitterionic structure.
75 citations
TL;DR: In this paper, a direct computational means for obtaining a measure of a substituent's total electron-attracting tendency is presented; it involves the calculation of ab initio SCF molecular orbital wavefunctions and electrostatic potentials of substituted amines.
75 citations