Sulfonamide

About: Sulfonamide is a research topic. Over the lifetime, 5475 publications have been published within this topic receiving 72308 citations. The topic is also known as: sulphonamide & sulfonamides.

Greene's Protective Groups in Organic Synthesis

Abstract: Preface to the Fourth Edition. Preface to the Third Edition. Preface to the Second Edition. Preface to the First Edition. Abbreviations. 1. The Role of Protective Groups in Organic Synthesis. 2. Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols. Ethers. Esters. Protection for 1,2- and 1,3-Diols. 3. Protection for Phenols and Catechols. Protection for Phenols. Ethers. Silyl Ethers. Esters. Carbonates. Aryl Carbamates. Phosphinates. Sulfonates. Protection for Catechols. Cyclic Acetals and Ketals. Cyclic Esters. Protection for 2-Hydroxybenzenethiols. 4. Protection for the Carbonyl Group. Acetals and Ketals. Miscellaneous Derivatives. Monoprotection of Dicarbonyl Compounds. 5. Protection for the Carboxyl Group. Esters. Amides and Hydrazides. Protection of Boronic Acids. Protection of Sulfonic Acids. 6. Protection for the Thiol Group. Thioethers. Thioesters. Miscellaneous Derivatives. 7. Protection for the Amino Group. Carbamates. Amides. Special -NH Protective Groups. Protection for Imidazoles, Pyrroles, Indoles, and other Aromatic Heterocycles. Protection for the Amide -NH. Protection for the Sulfonamide -NH. 8. Protection for the Alkyne -CH. 9. Protection for the Phosphate Group. Some General Methods for Phosphate Ester Formation. Removal of Protective Groups from Phosphorus. Alkyl Phosphates. Phosphates Cleaved by Cyclodeesterifi cation. Benzyl Phosphates. Phenyl Phosphates. Photochemically Cleaved Phosphate Protective Groups. Amidates. Miscellaneous Derivatives. 10. Reactivities, Reagents, and Reactivity Charts. Reactivities. Reagents. Reactivity Charts. 1 Protection for the Hydroxyl Group: Ethers. 2 Protection for the Hydroxyl Group: Esters. 3 Protection for 1,2- and 1,3-Diols. 4 Protection for Phenols and Catechols. 5 Protection for the Carbonyl Group. 6 Protection for the Carboxyl Group. 7 Protection for the Thiol Group. 8 Protection for the Amino Group: Carbamates. 9 Protection for the Amino Group: Amides. 10 Protection for the Amino Group: Special -NH Protective Groups. 11 Selective Deprotection of Silyl Ethers. Index.

Polynucleotide analogs containing sulfonate and sulfonamide internucleoside linkages

Abstract: The present invention provides for the preparation and use of ribo- and deoxyribo-nucleosides and polynucleotide analogs. The polynucleotide analogs are made of polynucleosides which contain sulfonate and sulfonamide linkages.

Adsorption of Sulfonamide Antimicrobial Agents to Clay Minerals

Abstract: Adsorption of three sulfonamide antimicrobials to clay minerals was investigated as a function of pH, ionic strength, and type of exchangeable cation. Sulfonamide antimicrobial adsorption exhibited pronounced pH dependence consistent with sorbate speciation and clay properties. Sulfonamide antimicrobials did not intercalate into montmorillonite, and surface charge density influenced sorption by determining adsorption domain size. Adsorption edge data were best fit to a model including terms for the cationic and uncharged species. Adsorption of uncharged sulfamethazine to montmorillonite was relatively insensitive to pH, ionic strength, and type of exchangeable cation, while that to kaolinite was highly sensitive to ionic strength. Adsorption of cationic sulfamethazine to montmorillonite exceeded that of the neutral species by 1-2 orders of magnitude, but was unimportant for kaolinite atthe pH values examined. Cation exchange appeared to contribute to sorption of cationic sulfonamide species to montmorillonite. Anionic sulfamethazine adsorption was negligible. The nature of the sulfonamide R group influenced the degree of adsorption of cationic and neutral species. Our results highlight the importance of considering sulfonamide speciation and clay surface charge density in predicting the transport of these antimicrobials.