Topic
Summation
About: Summation is a research topic. Over the lifetime, 954 publications have been published within this topic receiving 45593 citations. The topic is also known as: summation & sum of a sequence.
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12 citations
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TL;DR: In this article, the mossy fibers (MF) and the perforant path (PP) were used to stimulate interneurons in str. lacunosum moleculare (L-M) of CA3.
Abstract: Area CA3 receives two extrinsic excitatory inputs, the mossy fibers (MF) and the perforant path (PP). Interneurons with somata in str. lacunosum moleculare (L-M) of CA3 modulate the influence of the MF and PP on pyramidal cell activity by providing strong feed-forward inhibitory influence to pyramidal cells. Here we report that L-M interneurons receive two separate MF inputs, one to the dorsal dendrites from the suprapyramidal blade of the dentate gyrus (MFSDG), and a second to ventral dendrites from the str. lucidum (MFSL). Responses elicited from MFSDG and MFSL stimulation sites have strong paired-pulse facilitation, similar DCG-IV sensitivity, amplitude, and decay kinetics but target spatially segregated domains on the interneuron dendrites. These data demonstrate that certain interneuron subtypes are entrained by two convergent MF inputs to spatially separated regions of the dendritic tree. This anatomical arrangement could make these interneurons considerably more responsive to the excitatory drive from dentate granule cells. Furthermore, temporal summation is linear or slightly sublinear between PP and MFSL but supralinear between PP and MFSDG. This specific boosting of the excitatory drive to interneurons from the SDG location may indicate that L-M interneurons could be specifically involved in the processing of the associational component of the recognition memory.
12 citations
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TL;DR: In this paper, the effect of gabapentinentinentin on the threshold of pain summation was investigated in a sural nerve stimulation pain model including temporal pain summary and cold pressor test.
12 citations
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TL;DR: The time of transition from complete to absent temporal summation, ranging from 32 msec in photopic foveal vision to more than 320 msec in mesopic peripheral vision, is quite independent of age, retinal location and adaptation of the eye.
Abstract: Temporal summation as the relation of threshold intensity to presentation time of a stimulus has been tested in different retinal locations under photopic and mesopic conditions in 35 normal subjects of all ages. The characteristics of temporal summation is quite independent of age, retinal location and adaptation of the eye. The only variable is the time of transition from complete to absent temporal summation, ranging from 32 msec in photopic foveal vision to more than 320 msec in mesopic peripheral vision
12 citations
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TL;DR: Increased corticospinal excitability of the primary motor cortex is associated with more efficient inhibitory pain modulation as assessed by CPM, in healthy subjects, and motor-evoked potential amplitude and duration may be considered as an additional, objective and easy to measure parameter to allow for better individual assessment of pain modulation profile.
12 citations