Topic
Summation
About: Summation is a research topic. Over the lifetime, 954 publications have been published within this topic receiving 45593 citations. The topic is also known as: summation & sum of a sequence.
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01 Mar 2019
TL;DR: The results indicated that the ability of repetitive activation of individual excitatory synapses on spines to influence the electrical signaling in individual neurons is strictly limited to subthreshold responses.
Abstract: The physiology of individual synapses on dendritic spines is important because isolated and widely distributed spines are active during sensory information processing in vivo. We used acute cortical brain slices from the rat to investigate synaptic signal integration at the level of individual synapses on dendritic spines in layer 5 pyramidal neurons. We monitored subthreshold synaptic signals using a combination of voltage-sensitive dye recordings, patch-electrode somatic recordings, and 2-photon glutamate uncaging with holographic illumination. We describe the capabilities and limitations of this approach and demonstrate that imaging with an organic voltage-sensitive dye is presently a unique way to monitor temporal summation of uncaging evoked quantal excitatory synaptic potentials locally, at the site of origin on thin basal dendrites. The results indicated that the ability of repetitive activation of individual excitatory synapses on spines to influence the electrical signaling in individual neurons is strictly limited to subthreshold responses. We show that the underlying mechanisms, which control the temporal summation of excitatory synaptic potential in single synapses, can now be investigated with described methodology.
19 Apr 2001
TL;DR: The firing pattern of a neuron can be regulated, often by neurotransmitters acting via G protein-coupled receptors to modulate voltage-dependent ion channels.
Abstract: Neurons generate diverse patterns of action potentials, depending on the intrinsic electrical properties of the neurons and on synaptic inputs from other neurons. The firing pattern of a neuron can be regulated, often by neurotransmitters acting via G protein-coupled receptors to modulate voltage-dependent ion channels.
Keywords:
action potential;
bursting;
adaptation;
ion channel;
neurotransmitter
TL;DR: In this article, the authors examined whether the CPM effect would be different on pain induced by temporal summation than single stimuli in a group of low back pain patients, and found that repeated pressure pain may be better suited as the test stimuli, than single pressure pain and temporal summary of pressure pain, as the effect in absolute terms was greater.
01 Dec 1997
TL;DR: Two spike train analysis techniques are introduced to establish how the probability of firing in a neuron is dependent on the number of sequential spikes fired in another neuron (temporal summation) and in any other neuron (spatial summation).
Abstract: Two spike train analysis techniques are introduced to establish how the probability of firing in a neuron is dependent on the number of sequential spikes fired in another neuron (temporal summation) and in any other neuron (spatial summation). The Joint InterNeuronal-Arrival-Time/Cross-Interval (J-INAT/CI) Probability Mass Function (PMF) is used to deduce how a sequential (burst) firing pattern in any neuron is contributing to the generation of a spike in a reference neuron. Analogously, the Joint Inter-Spike-ArrivalTime/Cross-Interval (J-LSAT/CI) PMF is defined similar to the former PMF except that the contribution from only one other neuron is considered. These analyses can be used to establish the precise coupling relationship between the firing times of neurons both spatially and temporally.
TL;DR: In this paper , the authors used cold-induced spatial summation of pain (SSp) to investigate the effect of attention on the spatial tuning of nociceptive processing.