Topic
Surface plasmon resonance
About: Surface plasmon resonance is a research topic. Over the lifetime, 24909 publications have been published within this topic receiving 810976 citations. The topic is also known as: Surface plasmon resonance & SPR (technology).
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TL;DR: A simplistic and low-cost approach to glucose sensing, coupled with the sensing aggreagates' ability to scatter red light, suggests the potential use of these aggregates for use in physiological transdermal glucose monitoring, either for implantable skin sensors or glucose sensing tattoos.
Abstract: Gold colloids are well known to display strong plasmon absorption bands due to electron oscillations induced by the incident light. When the colloids are in proximity, the plasmon absorption bands are often perturbed. This has enabled us recently to successfully develop a glucose sensing platform based on the disassociation of dextran-coated gold colloids, cross-linked with Con A, by glucose. However, a much more useful and simpler property of gold colloids, which has been ill explored with regard to sensing, is their ability to efficiently scatter excitation light. We have found that our nanogold sensing aggregates are indeed efficient light scatters around the nanogold plasmon absorption band. By measuring the ratio of scattered light intensities at two different arbitrary wavelengths, 560 and 680 nm, glucose concentrations can be readily determined from a few millimolar up to ∼60 mM, using a simple white light LED and detection system. Further, by measuring the ratio of the scattered intensities, this ...
175 citations
TL;DR: This work presents a unique type of plasmon ruler comprised of peptide-linked gold nanoparticle satellites around a core particle, which was used as a probe to optically follow cell-signaling pathways in vivo at the single-molecule level.
Abstract: The use of plasmon coupling in metal nanoparticles has shown great potential for the optical characterization of many biological processes. Recently, we have demonstrated the use of “plasmon rulers” to observe conformational changes of single biomolecules in vitro. Plasmon rulers provide robust signals without photobleaching or blinking. Here, we show the first application of plasmon rulers to in vivo studies to observe very long trajectories of single biomolecules in live cells. We present a unique type of plasmon ruler comprised of peptide-linked gold nanoparticle satellites around a core particle, which was used as a probe to optically follow cell-signaling pathways in vivo at the single-molecule level. These “crown nanoparticle plasmon rulers” allowed us to continuously monitor trajectories of caspase-3 activity in live cells for over 2 h, providing sufficient time to observe early-stage caspase-3 activation, which was not possible by conventional ensemble analyses.
175 citations
TL;DR: In this article, a simple hexagonal lattice photonic crystal fiber biosensor using surface plasmon resonance phenomenon was proposed, where the analyte (sample) was placed outside the fiber structure instead of inside the air-holes.
Abstract: We propose a simple, two rings, hexagonal lattice photonic crystal fiber biosensor using surface plasmon resonance phenomenon. An active plasmonic gold layer and the analyte (sample) are placed outside the fiber structure instead of inside the air-holes, which will result in a simpler and straight forward fabrication process. The proposed sensor exhibits birefringent behavior that enhances its sensitivity. Numerical investigation of the guiding properties and sensing performance are conducted by finite element method. Using wavelength and amplitude interrogation methods, the proposed sensor could provide maximum sensitivity of 4000 nm/RIU and 320 RIU $^{-1}$ , respectively. The resolutions of the sensor are $2.5 \times 10^{-5}$ and $3.125 \times 10^{-5}$ RIU for wavelength and amplitude interrogation modes. The proposed sensor design shows promising results that could be used in biological and biochemical analytes detection.
175 citations
TL;DR: It is demonstrated the first in vivo application of plasmon coupling for molecular imaging of carcinogenesis, and molecular-specific gold bioconjugates to image epidermal growth factor receptor (EGFR) are described, which can be delivered topically and imaged noninvasively in real time.
Abstract: An effective cancer control strategy requires improved early detection methods, patient-specific drug selection, and the ability to assess response to targeted therapeutics. Recently, plasmon resonance coupling between closely spaced metal nanoparticles has been used to develop ultrasensitive bioanalytical assays in vitro. We demonstrate the first in vivo application of plasmon coupling for molecular imaging of carcinogenesis. We describe molecular-specific gold bioconjugates to image epidermal growth factor receptor (EGFR); these conjugates can be delivered topically and imaged noninvasively in real time. We show that labeling with gold bioconjugates gives information on the overexpression and nanoscale spatial relationship of EGF receptors in cell membranes, both of which are altered in neoplasia. EGFR-mediated aggregation of gold nanoparticles in neoplastic cells results in more than a 100-nm color shift and a contrast ratio of more than tenfold in images of normal and precancerous epithelium in vivo, dramatically increasing contrast beyond values reported previously for antibody-targeted fluorescent dyes.
175 citations
TL;DR: A novel sensor chip for use in surface plasmon resonance (SPR) biosensors has been developed to capture vesicles which may contain membrane-bound receptors and binding of cholera toxin to captured vesicle containing ganglioside GM(1) was demonstrated using SPR.
175 citations